摘要:

In a series of 121 patients with chronic granulocytic leukaemia (CGL) the frequence and prognostic significance of two cytogenetical features (absence of ph1‐chromosome and presence of ph1‐mosaicism) were studied. 13% of the patients were ph1‐negative, these patients showing a shorter survival than the ph1‐positive ones (P<0.005). 23 instances of ph1‐mosaicism were found (22.5%). This feature was observed either at diagnosis or after treatment, and irrespective of the patient's being in chronic or blastic phase of CGL, but in no case later than 2 years from diagnosis of the disease. ph1‐mosaicism patients vs the remainder of the ph1‐positive group were compared for survival, and no difference was found. The lack of prognostic significance of ph1‐mosaicism was evident regardless of the latter feature being detected at diagnosis or

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb02124.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The formation of fibroblastoid colonies by marrow cells in vitro has been used as a putative assay for a stem cell of haemopoietic stroma. Bone marrow from one patient with aplastic anaemia did not form any of these colonies, while its growth in diffusion chambers as an indirect measure of a haemopoietic stem cell was even better than normal. On the other hand, marrow from the other aplastic anaemia patient showed only quantitative decrease in the formation of fibroblastoid colonies and simultaneously grew very poorly in diffusion chambers. These patients were indistinguishable by the cytological examination of their marrow, however, the peripheral blood abnormalities were expressed less severely in the first patient. These results suggest the contribution of the defect in marrow cells, which form fibroblastoid colonies in vitro to the development of aplastic anaemia in these patients.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb02125.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

In a man aged 62 years with a 14‐year‐history of polycythaemia vera progressing into a myelofibrotic stage symptoms and signs of an intracranial tumour with increased intracranial pressure developed. CT scan as well as angiography of the right internal carotid artery revealed richly vascularized masses within the meninges. The patient died in endocarditis and progressive heart failure and at autopsy the intracranial masses were shown to be due to meningeal myeloid metaplasia. The literature is reviewed and it appears that myeloid metaplasia within the central nervous system might be more common than has been hitherto anticipated. A CT scan is to be recommended in myelofibrosis whenever symptoms and signs suggesting intracranial disease are pres

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb02126.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb02127.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY