摘要:

Fluoresceinated human albumin conjugated with histamine (FHA‐HIS) has been used for the demonstration of histamine receptors on human platelets. Such receptors were demonstrated on 40–63% of peripheral blood platelets in 4 healthy donors. The binding of FHA‐HIS was inhibited on 35–79% of the platelets by the histamine H1receptor antagonists diphenhydramine and clemastine. The histamine H2receptor antagonist cimetidine blocked the FHA‐HIS binding on 14–37% of the platelets. It is concluded that histamine H1as well as H2receptors occur on human platelets but the receptors are not equally distributed in the platelet

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02165.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

In a retrospective study of 44 adults with acquired bi‐ or pancytopenia without evidence of any causal disorder, the survival curve suggested the existence of a subgroup of short survivors, mainly with aplastic anaemia, with death within 4 months.The initial values of 14 single clinical, blood and bone marrow variables were significantly associated with survival<4 months. Stepwise multiple logistic regression analyses identified 2 combinations of variables displaying significant simultaneous associations with short survival: (i) increased % of non‐myeloid bone marrow cells and haemorrhagic manifestations initially; (ii) increased % of non‐myeloid marrow cells, circulating erythroblasts and no history of any drug exposure.The predictive capacities of a resulting estimate of the probability of short survival and of previously introduced prognostic indices were approximately equal. The frequency of a correct prediction of a survival shorter than 4 months was in the range of 0.71–0.78 and that of longer survival in the range of 0.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02166.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Pentostatin (2′‐deoxycoformycin, DCF) was administered to 17 patients with a variety of lymphoid neoplasms, both T‐ and B‐cell, that were refractory to conventional treatments. Several responses and 2 complete remissions occurred. Toxic effects were less severe than previously described: this may be attributable to relatively low doses of DCF or to precautions taken to prevent tumour lysis syndrome. DCF appears valuable as a second‐line treatment in non‐Hodgkin's lymphomas and as initial treatment in T‐cell chronic lymphocytic leukaemia and mycosis fungoides. Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with DCF. The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02167.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

8 patients with clinical and haematological features suggestive of hairy cell leukaemia are described. During their initial illness morphologic and cytochemical evidence of hairy cell leukaemia were lacking in all but 2 patients. A common highly characteristic histopathologic finding was reticulin fibrosis in the bone marrow, present in all patients at first presentation. The term spongy lymphoid myelofibrosis is proposed for such cases, which may represent a variant type of hairy cell leukaemia or an early stage of the disease.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02168.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Platelet antibodies of IgG and IgM class were detected in the serum of a patient with infectious mononucleosis and thrombocytopenia. Platelet counts and antiplatelet antibody levels were inversely correlated, but both normalized after complete recovery of the patient.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02169.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

A 16‐year‐old female was admitted because of rapidly progressive fatigue, severe anaemia and icterus. The S‐bilirubin was 190 μmol/l, COHb 7.3% and high amounts of free Hb in plasma were present. The Coombs' direct test was strongly positive with anti‐IgG but negative with anti‐IgM and anti‐C3. Conventional therapy with very high doses of hydrocortisone i.v., cyclophosphamide, azathioprine, and transfusions of washed packed red cells proved ineffective. During 5 consecutive days she also received i.v. infusions of gammaglobulin (25 g each day). Nevertheless, her condition deteriorated and 3 plasma exchanges were carried out with impressive clinical and laboratory effects. After the 3rd plasma exchange, the patient did not require further transfusions of packed red cells. Therapy with corticosteroids could be rapidly reduced and she was discharged after 5 weeks with a normal blood picture. Since then she has remained in exce

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02170.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Non‐transferrin plasma iron concentrations were determined in 45 normal controls and in 37 patients with Hb H disease and 104 patients with β‐thalassaemia/Hb E disease. This revealed that non‐transferrin plasma iron exists in cases with severe iron overload, more striking in β‐thalassaemia/Hb E than in Hb H disease. Non‐transferrin plasma iron is associated with higher transferrin iron saturation and higher plasma ferritin levels. The most striking finding was the significantly higher non‐transferrin plasma iron in splenectomized patients with β‐thalassaemia/Hb E disease than in the non‐splenectomized patients. In view of the potential toxicity of non‐transferrin iron, this fraction of iron may be responsible for tissue damage in these patients especial

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02171.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

In order to throw some light on the mechanisms underlying exercise‐induced thrombocytosis, we investigated 15 healthy persons subjected to short‐term vigorous pedalling on a bicycle ergometer 1 d after injection of autologous111In‐labelled platelets. Scintigraphic studies during the post‐exercise period showed the spleen to be the major platelet‐releasing organ. There was, however, a considerable interindividual variability manifested as signs of a contributing platelet release from the lungs in some cases and of deposition of a surplus of released platelets in the liver of others. Our results also seem to be compatible with the existence of an intravascular marginal plat

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02172.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

A case of platelet cyclo‐oxygenase deficiency in a Japanese was investigated. There was a marked decrease of aggregation with collagen and absence of aggregation with epinephrine and arachidonic acid. The platelet response to a labile aggregation stimulating substance (LASS) was normal. There was no biosynthesis of prostaglandin endoperoxides from arachidonate. The platelets, including granular volume, showed no ultrastructural abnormalities. The responses to various inducers of platelet aggregation, except for arachidonate, were different from the cases described by others. It is concluded that the defective platelet function, due to a deficiency of platelet cyclo‐oxygenase, is heterogene

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02173.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

The in vitro bone marrow growth of 2 patients with aprindine‐induced agranulocytosis was studied. Granulocyte‐macrophage committed stem cell (CFU‐C) growth is inhibited by aprindine in a dose dependent manner. 50% inhibition of CFU‐colony growth (TD50) was seen at 5.1 and 3.4 μg aprindine/ml medium respectively. The TD50 of control marrow CFU‐C was 3.2 μg/ml. 100% inhibition was seen at 16 μg aprindine/ml, both in patients and controls.Pluripotential stem cell growth (CFU‐GEMM) in control marrow was equally inhibited in a dose dependent manner by aprindine, though to a lesser extent (TD50: 9.1 μg/ml) and with relative sparing of pure megakaryocyte and erythroid colonies. Co‐culturing of patients marrows with their respective acute phase serum did not inh

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02174.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY