ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb00686.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Clinical, haematological and biochemical features in 42 subjects with S‐beta thalassaemia (31 subjects with S‐beta° thalassaemia and 11 subjects with S‐beta+thalassaemia); and in 42 with homozygous sickle cell disease were compared. Persistent splenomegaly was more common and painful crises less common in the S‐beta thalassaemia group. Total Hb was higher and reticulocyte count lower in S‐beta+thalassaemia than in S‐beta° thalassaemia or SS disease. Microcytosis was marked in the S‐beta thalassaemia group while the MCV was normal in sickle cell anaemia. Hb F was significantly higher in the S‐beta° thalassaemia group, without any influence on the severity of the disease. Many features suggest that sickle cell thalassaemia is more severe in Algeria than in Negro subjects and similar to the disease i

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb00687.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

The growth pattern in agar culture and the karyotype of bone marrow cells were studied in 79 patients with untreated acute non‐lymphocytic leukaemia (ANLL). Results were divided into the following groups: (A) colony and cluster formation; (B) growth of less than 600 small clusters per 105cells; (C) growth of more than 600 small clusters; (D) no growth in agar. Cytogenetically, the patients were divided into 3 categories: NN, normal metaphases only; AN, both abnormal and normal metaphases and AA, abnormal metaphases only. An association was seen between growth pattern and karyotype: the majority of NN patients (33/37) belonged to group (A+B) while in group (C+D) 20/24 patients were AN or AA. 37 patients were prognostically evaluable. The growth pattern in agar but not the cytogenetic pattern had prognostic implications. 25 patients with acute lymphocytic leukaemia (ALL) were also studied at diagnosis. Different growth patterns in agar had no impact on prognosis. No relationship was detected between growth pattern and karyotype in AL

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb00688.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

2 patients with diabetes insipidus established in the preleukaemic phase of acute myeloid leukaemia are described. Both patients had probably coincidentally an empty sella turcica showed by a computerized tomography. In one of them, leukaemia developed secondary to a cytostatic therapy for a vesical cancer. In this patient, blast cells appeared in cerebrospinal fluid after the patients had become polyuric and later on autopsy findings showed a peripituitary leukaemic infiltrate. In the other patient, diabetes insipidus and the acute phase of leukaemia developed after a long period with a dysmyelopoietic syndrome. Hormonal tests suggested a hypothalamic injury in both patients due to a leukaemic infiltrate at least in the former of them. It is concluded that diabetes insipidus as a consequence of hypothalamic lesion may develop in the preleukaemic phase of acute myeloid leukaemia and become evident even before any other symptoms of leukaemia have manifested.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb00689.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

The ultrastructural localization of acid alpha‐naphthylacetate esterase (ANAE) activity was studied in normal and neoplastic human monocytic and lymphocytic cells including hairy cells. Normal monocytes and malignant monocytic cells from cases of AML‐M4 and ‐M5 (FAB‐classification) displayed fundamentally the same ANAE staining pattern with reaction products localized to the external surface of the plasma membrane and to small vesicles close to this membrane, more rarely to larger intracytoplasmic vesicles containing endocytosed material or cellular debris. The enzyme activity of the neoplastic cells increased with morphological differentiation. Certain normal blood lymphocytes and T cell‐derived CLL cells showed the reaction product associated with paranuclearly located clusters of vesicular structures, extending from the membranes into the adjacent cytoplasm. Gall bodies were often found in the vicinity and were invariably positive for ANAE. Now and then, plasma membrane activity was present, but never as pronounced as in monocytes. Hairy cells demonstrated a pattern of reaction very similar to that of monocytic cells, whereas B cell‐derived CLL cells and lymphoblasts of T‐ and common type ALL were generally

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb00690.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

A 17‐year‐old male whose initial presentation of chronic myeloid leukaemia (CML) was necrosis of the right femoral head is reported. This is the first case report to our knowledge of CML presenting with such a lesion and is of further interest in that almost all reported cases of destructive bony lesions in this disease have been associated with blast transformation. Our patient in contrast has remained in stable chronic phase for over 30 mon

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb00691.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

The template bleeding time (TBT), ADP‐induced platelet aggregation, and serum production of TXB2were measured in healthy young male subjects immediately before, and on days 1, 4 and 6 after the ingestion of 1 single dose of 500 mg acetylsalicylic acid (ASA) in 3 different formulations: Aspirin® (Bayer), and the 2 enteric‐coated formulations Reumyl® (Hässle) and Premaspin® (Lääke). The ingestion of Aspirin® resulted in a significant prolongation of the TBT over a period of 6 d. However, after the ingestion of the same amount of ASA in the 2 enteric coated formulations, the TBT as measured on day 6 had become normalized. After the ingestion of Aspirin®, there was no reappearance of the second wave of ADP‐induced platelet aggregation during the study period; however, after the ingestion of the 2 enteric‐coated formulations, secondary platelet aggregation occasionally returned on day 6. In response to the intake of each of the 3 ASA formulations, the serum TXB2production as measured 24 h later was almost completely inhibited. In each of the 3 study groups, the TXB2formation as measured on day 6 was still signifi

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb00692.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Between 1978 and 1980, 45 cases of acute monoblastic leukaemia have been diagnosed, treated and followed in our institute. Morphological diagnosis was performed according to the French‐American‐British classification. Tumoral syndrome (particularly extra‐medullary) and hyperleucocytosis were the most striking findings at the time of diagnosis. Cytogenetic analysis performed in 31 cases before treatment has showed that abnormality of the long arm of chromosome 11 seemed to be more frequently associated with the poorly differentiated cytological subtype M5 (a). Intensive chemotherapy with zorubicine and cytosine arabinoside led to complete remission in 75 % of the cases. Central nervous system prophylaxis appeared definitively useful in preventing meningeal relapse. Despite a prolongation of the median duration of complete remission which now reaches 12 months, the prognostic is still

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb00693.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Serum ferritin was measured in 46 Chinese patients with Hb H disease (HbHD) and compared with 84 controls according to age group. Ferritin levels were elevated in 14 of 20 males and 20 of 26 females and the extent of the abnormality increased with age. Splenectomy did not appear to be associated with particularly high levels of serum ferritin in this disease.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb00694.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Colony formation by haematopoietic progenitors from the bone marrow was studied in 44 patients with a myelodysplastic syndrome. Erythroid progenitors BFU‐E and CFU‐E were cultured in methyl cellulose, and granulocyte‐macrophage precursors CFU‐GM in agar. 3 of 32 patients showed normal numbers of BFU‐E colonies; in all the other cases the number of these colonies was below the normal range. CFU‐E colony formation was subnormal in all cases. 23 of 44 patients grew normal numbers of colonies and clusters in CFU‐GM cultures. These patients had refractory anaemia with ring sideroblasts (FAB‐classification) or 5q‐ karyotype anomaly in the marrow. Patients lacking both of these findings exhibited reduced colony formation or excessive growth of colonies and/or clusters, with few exceptions. In conclusion, we found that erythroid colony formation was defective in all cases. Normal granulocyte‐macrophage colony formation was associated with refractory anaemia with ring sideroblasts or the presence of 5q

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb00695.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY