ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb01158.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A patient with multiple myeloma is reported with severe hypogammaglobulinaemia but without monoclonal immunoglobulin (M‐component) in the serum or Bence Jones protein in the urine. In May‐Grünwald‐Giemsa stained bone marrow film 45 % of the cells resembled plasma cells. Marrow immunofluorescent studies showed no increase of immunoglobulin containing cells. Ultrastructural studies showed a large number of cells with a well developed rough endoplasmic reticulum and other morphological features characteristic for plasma

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb01159.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Testicular function was estimated by sperm counts, hormone assays and recording of reported conceptions in 9 patients irradiated for malignant lymphoma. The treatment had been an inverted ‘Y’ field including the inguinal regions with, in addition, a mantle field in 8 patients.Azoospermia or severe oligozoospermia was found in all but 1 patient, and the FSH levels were uniformly elevated. Testosterone and LH were within normal limits except in 2 patients with slightly subnormal testosterone levels.7 of the patients were married to women of fertile age, and in 3 cases the wife became pregnant and gave birth to a healthy child. The time lapses from irradiation to conception were 18, 40 and 57 months. 2 of these patients had severe oligozoospermia on examination 2 and 4 months respectively from conception. Thus fertility may possibly be underestimated by sperm counting and hormone assays after this type of radiother

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb01160.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

In a patient with chronic erythroleukaemia an isochromosome 17q was identified in all bone marrow metaphases analyzed. In addition, these cells were characterized by hypodiploidy and the presence of 3 different marker chromosomes. Approximately 50 % of dividing cells in the marrow were bizarre‐looking polyploids. The identification by Giemsa banding of i(17q) in this case of erythroleukaemia supports the concept that there are common cytogenetic characteristics among malignant myeloproliferative disorder

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb01161.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Neutropenia is an almost constant feature of Chediak‐Higashi syndrome (CHS). There is evidence for a central mechanism of neutropenia. Ultrastructural studies of the bone marrow from a child with CHS showed marked autophagia phenomena within myeloid precursor cells and mature neutrophils. Autophagic vacuoles were randomly distributed in the cytoplasm of the cells from the granulocytic series and some of them contained giant granules which thus appeared particularly resistant to the autophagic process. The vital cellular damage through endophagocytosis suggests the possibility of intramedullary destruction as an explanation for neutropeni

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb01162.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The red cell glutathione‐peroxidase (GSH‐Px) activity of 9 normal subjects is compared with that of 15 cases of iron deficiency anaemia and with 13 cases of heterozygous beta‐thalassaemia with the same degree of anaemia and hypochromia. 2 cases of sideroblastic anaemia with high serum iron levels were also examined. Enzymatic activity was found to be significantly decreased in iron deficiency anaemia (about 55 % of normal range), while it was not affected in heterozygous betathalassaemia and it was increased in the 2 cases of sideroblastic anaemia.Moreover, GSH‐Px activity exhibited a significant correlation with serum iron levels in all the patients studied.The observed modifications in GSH‐Px activity are not correlated with erythrocyte ageing because reticulocyte‐poor fractions exhibited GSH‐Px activity which was not significantly reduced in respect of the reticulocyte‐rich ones.These data seem to suggest that iron has a crucial connection with erythrocyte GSH‐Px and that the enzyme deficiency may be of some importance in explaining the decreased red cell survival observed in severe iron‐

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb01163.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Lipids of rat plasma and erythrocytes were analysed during hyperlipidaemic diet and clofibrate treatment. The diet increased the plasma cholesterol and phospholipid concentrations after 3 weeks' lipid feeding. Clofibrate in a dose of 200 mg/kg body weight did not inhibit the increase in plasma cholesterol and phospholipid contents, but significantly decreased the concentration of plasma triglycerides.The lipid diet slightly increased the erythrocyte cholesterol and phospholipid concentrations without affecting the red cell morphology or reticulocytosis. After 1 week's treatment, clofibrate in a dose of 200 mg/kg body weight caused a 2‐fold increase in the cholesterol content and a rise in the cholesterol‐phospholipid ratio of red blood cells of rats fed the hyperlipidaemic diet. These results suggest that the erythrocyte cell membrane can increase its cholesterol content and possibly play a role in cholesterol transp

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb01164.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

In a consecutive series of 841 patients whose bone marrows were cytogenetically investigated because of verified or suspected haematological disease, 11 patients were found to have at least 10 % polyploid bone marrow mitoses. The chromosome numbers varied greatly between the cells of the same patients and between the patients. In 4 cases, the number was nearly or exactly tetraploid and in 1 patient a prevalent octaploid line was seen. Structurally abnormal marker chromosomes were seen in 8 of the patients. A total of 31 bone marrow chromosome counts were performed on a young woman with acute myelomonocytic leukaemia who had had several drug‐induced remissions during the 3 1/2 years of disease. The results were related to the clinical findings. On several occasions a clear‐cut correlation was noted between high proportions (nearly 100 %) of polyploid cells and relapse on the one hand and low proportions (as low as 0 %) of polyploids and remission on the other.Of the 11 patients, 2 had chronic myeloid leukaemia, 3 acute myelomonocytic leukaemia, 3 acute myeloid leukaemia and a further 3 some other malignant haematological disorders. We conclude that polyploidy is a feature associated with rare cases of leukaemia and other malignant diseases. It is often a sign of a poor progno

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb01165.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The proliferating granulocyte precursor pool of rat bone marrow was labelled during DNA synthesis by continuous infusion and by single injection of3H‐thymidine (3H‐TdR), as well as by single injection of125I‐iododeoxyuridine (125I‐UdR). The appearance of neutrophilic granulocytes in the blood stream after these various labelling procedures was studied by autoradiography. Labelling patterns of blood neutrophils were identical during continuous infusion and after single injection of3H‐TdR, and 100 % labelling of the blood compartment was achieved. This result indicated reutilization of DNA catabolites to occur in granulocytopoiesis leading to continuous availability of3H‐labelled DNA precursors even after a single injection of3H‐TdR. Attempts to suppress reutilization of label by infusion of cold thymidine 1 h after injection of3H‐TdR were unsuccessful. However, a change in the labelling pattern of blood neutrophils was seen after single injection of125I‐UdR, a DNA precursor poorly reutilized in comparison to3H‐TdR. This result provided further evidence for reutilization of DNA catabolites by the cell system investigated. A comprehensive discussion of the results indicates that thymidinemonophosphate is the biochemical level of reutilization in

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb01166.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb01167.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY