ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02183.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Variations in the centrifugal force (g) used to prepare platelet‐rich‐plasma (PRP) alter not only the number of platelets therein but also their size and reactivity. Anticoagulants also affect these parameters. According we suggest that PRP preparations need to be strictly standardised. Critical comment on the use of the platelet aggregation model as a means of assessing 5‐hydroxytryptamine receptor function is inc

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02184.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

A patient is reported, in whom clinical and biochemical evidence of connective tissue disease preceded the diagnosis of hairy‐cell leukaemia by at least 2 years. The pathogenetic mechanism(s) responsible for the coexistence of hairy‐cell leukaemia with vasculitis and rheumatic disease is discussed. It is proposed that the 2 diseases may share a common predisposing factor, or that the hairy cells may elicit disturbances in immune homeostasis, implying a dysfunction of T suppressor cells. Hairy‐cell leukaemia should be considered in the differential diagnosis in cases of unexplained febrile illness associated with pancytopenia and signs of connective tissue di

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02185.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

In a family of 5 boys and 6 girls, 3 brothers have clinical dyskeratosis congenita. Teeth from 2 of the patients were taurodent, and mineral density of the enamel was significantly different from normal. The haematopoietic marrow was hypocellular and there was striking prominence of plasma cells having normal morphology; no granulomata were demonstrated. The decreased erythroid precursors in the marrow correlated with quantitatively reduced erythropoiesis demonstrated on ferrokinetic studies. Recurrent infections occurred but could not be related to neutropenia, and granulocytes and monocytes retained normal function. No abnormality was demonstrated in humoral or cellular immune mechanisms.While superficially similar, dyskeratosis congenita and Fanconi's anaemia are genetically distinct, being X‐linked in the former and inherited as an autosomal recessive in the latte

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02186.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

In 87 patients with Ph1positive chronic granulocytic leukaemia (CGL), the bone marrow iron content was studied on smears obtained at diagnosis. A low sideroblast score and a decreased or absent marrow iron on semiquantitative estimation were found in 91 % and 85 % of cases, respectively. These findings did not correlate with blood parameters reflecting iron status such as Hb concentration, mean corpuscular volume, mean corpuscular haemoglobin, serum iron, total iron‐binding capacity and transferrin saturation, which were normal in most cases. In 30 patients, initial serum ferritin was estimated, normal or slightly increased levels being as a rule found. In 24 of such patients, serum ferritin was again measured in remission following busulphan and, although values remained normal, a significant decrease was observed with respect to the initial levels (P<0.001). Thus, in spite of the consistent marrow pattern of iron depletion, initial iron stores appear to be normal in CGL. It seems, however, that the disease activity may partially influence the serum ferritin level

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02187.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

The Bayesian multivariate statistical method was applied to determine the relative strength and optimal combination of 17 variables in predicting survival of 151 patients with non‐Hodgkin's lymphomas assigned as non‐cleaved follicular center‐cell and immunoblastic sarcoma types according to the classification of Lukes&Collins. Considering all the factors simultaneously, the analysis showed that the combination of stage, Hb level and location of the lymphoma was included in the best predictive model at each survival time studied. Additional factors were erythrocyte sedimentation rate, thrombocyte count and leucocyte count. Of the histological variables, only growth pattern and mitotic ratio in the biopsy specimen remained significant. At manually controlled computer simulation with these best indicators, this model would have given a correct classification for 69–78 % of the patients at the 4 survival times studied. One can thus expect about 70 % correct prognoses using thi

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02188.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Elevated levels of platelet‐associated IgG and/or IgM were found in 15 of 18 patients with myelofibrosis (83 %). All but 5 patients with elevated PAIg had active disease. The amounts of PAIg were not correlated to either S‐Ig, platelet count or spleen size. Levels of PAIgG well above the normal range were especially found in patients with short duration of disease and/or a transitional myeloproliferative state. It is debated whether immune‐mediated platelet dysfunction may be of importance for the development of bone marrow fibrosis, mediated by the release of platelet‐derived growth factors in the bone marrow. Elevated PAIg may also contribute to abnormal haemostasis and thrombocytopenia in myelof

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02189.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

A case of refractory anaemia with excess of blasts (RAEB) terminating with clinical and haematological picture of Ph1negative chronic myeloid leukaemia (CML) is reported. It is suggested that the same abnormal clone of cells is responsible for the initial picture of the RAEB and the terminal CML picture.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02190.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

We report a case of dyskeratosis congenita (DCG) with neutropenia, lymphocytopenia and thrombocytopenia. Peripheral blood T lymphocytes (T cells) were proved to have a suppressive effect on the colony forming unit granulocyte‐macrophage (CFU‐GM). Splenectomy caused a transient increase of neutrophil count with the disappearance of the suppressive T cell activity. However, pancytopenia recurred without re‐appearance of suppressive T cell act

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02191.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Normotest (NT) is a standardized reagent sensitive to changes in concentration of factors II, VII and X. It has been proposed as a useful screen for the liver synthetic function. We carried out a multicentre study aimed to compare in 5 different labs variability and reproducibility of results, normal ranges and manual versus instrumental techniques. NT values were significantly different in the 5 labs, regardless of how the results were expressed. However, within each lab, the results of manual and instrumental techniques were usually not different, providing they were expressed as ratios of test to reference plasmas. Within‐lab, between‐day reproducibility was much greater when results were expressed as ratios than as %s; reproducibility was also greater with the instrumental than with the manual technique. With both techniques, normal ranges established in each lab were much more uniform when the results were expressed as ratios than as %s. On the whole, this study suggests that NT results should be expressed as ratios, that instrumental techniques should be preferred to manual techniques, and that each lab should establish its own normal ra

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1984.tb02192.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY