1. |
Erythrocyte and Platelet Glucose 6‐Phosphate Dehydrogenase in Normal and Mutant Caucasians |
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Scandinavian Journal of Haematology,
Volume 6,
Issue 1,
1969,
Page 5-9
J. C. G. Doery,
J. Hirsh,
G. C. de Gruchy,
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摘要:
The activity, pH optimum and electrophoretic mobility of platelet glucose‐6‐phosphate dehydrogenase (G6‐PD) was investigated in subjects with severe Mediterranean type G6‐PD deficiency. Enzyme activity was less than 1% of normal in erythrocytes and 20% of normal in platelets. Investigation of pH optimum and electrophoretic mobility indicated that the mutant enzyme was present in the platelets. It is suggested that the very low activity of the enzyme in erythrocytes is due to a combination of a low specific activity and an increased susceptibility of the mutant enzyme to inactivation in the erythrocyte envi
ISSN:0036-553X
DOI:10.1111/j.1600-0609.1969.tb01794.x
出版商:Blackwell Publishing Ltd
年代:1969
数据来源: WILEY
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2. |
Haemoglobin S‐D Disease in a Turkish Family |
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Scandinavian Journal of Haematology,
Volume 6,
Issue 1,
1969,
Page 10-14
Sinasi ÖZsoylu,
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摘要:
A three‐year‐old Turkish boy with haemoglobin S‐D disease and ventricular septal defect is reported in detail, mentioning his three siblings with the same disorder. The patient showed marked haemolytic anaemia and growth retardation. His father possibly had homozygous Hb D disease, and the mother had sickle cell trait. An aplastic crisis was found during his hospitaliz
ISSN:0036-553X
DOI:10.1111/j.1600-0609.1969.tb01795.x
出版商:Blackwell Publishing Ltd
年代:1969
数据来源: WILEY
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3. |
Experimentally Increased Production of a Rabbit Antibody Resembling a Natural Human Agglutinin |
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Scandinavian Journal of Haematology,
Volume 6,
Issue 1,
1969,
Page 15-24
Ove J. Mellbye,
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摘要:
Normal rabbit sera, absorbed with normal human red cells, contained a γM‐globulin causing reversible agglutination of trypsinised human red cells. The amount of this antibody increased after immunization with normal human red cells, and it now consisted of both γM‐ and γG‐globulin. The agglutination was still reversible.The experiments supported the hypothesis that the natural antibody in human sera causing reversible agglutination of trypsinised human red cells is due to antigenic stimulation by structures revealed on normal red cells during their destructio
ISSN:0036-553X
DOI:10.1111/j.1600-0609.1969.tb01796.x
出版商:Blackwell Publishing Ltd
年代:1969
数据来源: WILEY
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4. |
Studies of Platelet Adhesiveness with Reference to Platelet Age |
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Scandinavian Journal of Haematology,
Volume 6,
Issue 1,
1969,
Page 25-30
Zoran Rolovic,
Mario G. Baldini,
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摘要:
In this study, autologous human platelets labelled with31Cr were infused in healthy volunteers and their adhesiveness to glass was repeatedly measured during their survival in the circulation using the Salzman's technique.51Cr‐specific activity was determined seperately for the ‘adhesive’ and ‘non‐adhesive’ platelets and expressed as a ratio of the two values. This ratio was found to be approximately 1 in all the conditions studied. The results indicated: (1) that platelet labellingin vitrowith51Cr did not alter platelet adhesiveness to glass, and (2) that aging of the platelets in the circulation was not associated with a change in their adhesiveness.Other experiments were done using platelets which had been damaged by a 24hour storage at 4°C. before infusion. The results demonstrated that although survival of these platelets was drastically reduced, their adhesive property to glass remained unchanged. It was concluded that a large ‘reservoir’ of adhesive property must exist in the platelets and that this is independent of the damage produced by cell aging in the circulation and by stora
ISSN:0036-553X
DOI:10.1111/j.1600-0609.1969.tb01797.x
出版商:Blackwell Publishing Ltd
年代:1969
数据来源: WILEY
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5. |
Ring‐Shaped Nuclei of Granulocytes in a Patient with Acute Erythroleukaemia |
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Scandinavian Journal of Haematology,
Volume 6,
Issue 1,
1969,
Page 31-32
Per Stavem,
Peter F. Hjort,
Erik Vogt,
Carl B. van der Hagen,
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摘要:
A patient with acute erythroleukaemia had a large number of ring‐shaped granulocyte nuclei. Cytogenetic studies showed normal chromosomes. A hereditary anomaly was unlikely, since his 2 children were normal. Therefore, the anomaly was probably acquired and a result of the acute erythroleukaemi
ISSN:0036-553X
DOI:10.1111/j.1600-0609.1969.tb01798.x
出版商:Blackwell Publishing Ltd
年代:1969
数据来源: WILEY
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6. |
Aggravation of Congenital Spherocytosis during Infectious Mononucleosis |
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Scandinavian Journal of Haematology,
Volume 6,
Issue 1,
1969,
Page 33-35
H. C. Godal,
E. Skaga,
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摘要:
A case of infectious mononucleosis complicated by brisk haemolysis is reported. Evidence is presented that haemolysis was due to clinical manifestation of congenital spherocytosis.
ISSN:0036-553X
DOI:10.1111/j.1600-0609.1969.tb01799.x
出版商:Blackwell Publishing Ltd
年代:1969
数据来源: WILEY
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7. |
Iron‐Deficient Erythropoiesis in Non‐Anaemic Young Men |
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Scandinavian Journal of Haematology,
Volume 6,
Issue 1,
1969,
Page 36-38
Henrik Isager,
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摘要:
As a link in a study on the occurrence of iron deficiency in connection with adolescence a blind test, using iron and placebo, was performed on army recruits. Changes in haematocrit, serum iron, and transferrin in iron‐treated and placebo‐treated subjects were compared. A significant response to iron medication was found in respect to haematocrit (increase) and transferrin (decrease). The haematocrit response to iron was most marked in those subjects who had shown haematocrit values at the upper end of the normal range prior to the test. Comparison of pre‐treatment haematocrit values and transferrin revealed that persons having haematocrit values in the range 47–52% showed significantly higher transferrin values than the remainder of the subjects.It is assumed that iron‐deficient erythropoiesis may develop in young men exposed to a particularly vigorous hormonal stimulation of the eryth
ISSN:0036-553X
DOI:10.1111/j.1600-0609.1969.tb01800.x
出版商:Blackwell Publishing Ltd
年代:1969
数据来源: WILEY
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8. |
Numerous Lipid‐Containing Vacuoles in the Myeloblasts of Two Patients with Acute Leukaemia |
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Scandinavian Journal of Haematology,
Volume 6,
Issue 1,
1969,
Page 39-41
Per Stavem,
Peter F. Hjort,
Michael Jeremic,
Hans G. Dedichen,
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摘要:
A report is given of two patients with acute myeloblasts leukaemia who showed an extreme degree of lipid vacuolization in practically all myeloblasts in the bone marrow as well as in the peripheral blood.
ISSN:0036-553X
DOI:10.1111/j.1600-0609.1969.tb01801.x
出版商:Blackwell Publishing Ltd
年代:1969
数据来源: WILEY
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9. |
Iso‐ and Heteroagglutinins in Human Fetal and Neonatal Sera |
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Scandinavian Journal of Haematology,
Volume 6,
Issue 1,
1969,
Page 42-48
P. Toivanen,
T. Hirvonen,
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摘要:
Maternal AB and sheep cell haemagglutinins were found in the human fetus after the 13th to 14th week of gestation. In fetuses aged 18 weeks or more they were observed as frequently as in full‐term newborns, 56.6% of which had isoagglutinins and 57.6% heteroagglutinins. The occurrence of maternal heteroagglutinins in neonatal sera was not dependent on the ABO group of the mother as it is with isoagglutinins. Heteroagglutinins of the IgG class were found equally in mothers of different ABO groups. Isoagglutinins against erythrocytes of the mother's group were detected in 8 out of 44 neonatal sera, but in none of 10 sera from fetuses aged 14 to 19 weeks. IgM concentrations in neonatal sera with and without isoagglutinins of fetal origin revealed that IgM synthesized by the healthy fetus consists mainly of antibodies other than isoagglutinin
ISSN:0036-553X
DOI:10.1111/j.1600-0609.1969.tb01802.x
出版商:Blackwell Publishing Ltd
年代:1969
数据来源: WILEY
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10. |
Fetal Development of Red Cell Antigens K, k, Lua, Lub, Fya, Fyb, Vel and Xga |
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Scandinavian Journal of Haematology,
Volume 6,
Issue 1,
1969,
Page 49-55
P. Toivanen,
T. Hirvonen,
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摘要:
Red cell antigen k occurs in the same frequency and strength as in adults in fetuses of 9 weeks or more and antigens Fya, Fyband Vel in fetuses aged at least twelve weeks. Antigen K was encountered twice, in fetuses of 14 and 16 weeks. Lubappears weaker in fetuses than in adults; it was not detected in a fetus of 9 weeks although both parents were Lu(a–b+). Xgawas found to be yet more poorly developed before birth; it was demonstrated in only four out of 23 fetuses. Its frequency in fullterm newborns was, however, the same as in adults, but with lower score
ISSN:0036-553X
DOI:10.1111/j.1600-0609.1969.tb01803.x
出版商:Blackwell Publishing Ltd
年代:1969
数据来源: WILEY
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