摘要:

The inhibitory effects of human endothelial cells (ECM) and PGI2(prostacyclin) on platelet function have been examined in 60 healthy subjects. 5 groups were studied. I. 10 women (19–33 yrs.); II. 10 women (21–31 yrs.) using combined oral contraceptives; III. 10 postmenopausal women (45–66 yrs.); IV. 20 men (24–48 yrs.) and V. 10 men (48–71 yrs.).Spontaneous platelet aggregation in platelet‐rich plasma (PRP) was commonly observed in groups II, III, and V. This was prevented when PRP was incubated with ECM, aspirin (ASA), or PGI2. ADP‐induced platelet aggregation (PA) was always reduced by ECM, but significantly less in groups II and III. Collagen‐induced PA was inhibited by ECM, but less in groups I, II, III and V than in young men (IV). ECM significantly reduced collagen‐induced prostaglandin (MDA) production in platelets. Again, the inhibitory effect was significantly reduced in groups II and III. Platelet factor 3 activity, measured after exposure of PRP to ADP, was significantly reduced by ECM, but was significantly less in groups II, III, and V than in group I. Less of an inhibitory effect of PGI2upon ADP‐induced PA was shown by all groups of females than by the

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00352.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

In order to determine if there were any relationships between thrombopoietin, erythropoietin and erythrogenin, supernatant fluids from culture lines of foetal mouse liver, foetal and adult bovine kidney, and adult rabbit kidney cells have been assayed for their content of the presumptive humoral regulators of haematopoiesis. Hormone production varied markedly from one culture line to another confirming other studies that the optimal culture conditions for the generation of haematologically‐active hormones have not been delineated. The lack of any discernable relationship between the production of thrombopoietin and erythropoietin, thrombopoietin and erythrogenin or erythropoietin and erythrogenin suggests that these materials represent three distinct entitie

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00353.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Macrothrombocytopenia associated with glomerulonephritis and deafness has only been reported in a few patients since it was first described in 1972. We present a patient with macrothrombocytopenia, glomerulonephritis, progressive uraemia and progressive sensorineural deafness associated with cystic medianecrosis of the ascending aorta and malformation of the aortic valves. The patient had consistently low platelet counts but no clinical signs of a defect haemostasis. The giant platelets were characterized by their size, averaging 11 μm in diameter, elaborate maze‐like membrane formations, abundance of microtubules, and the total absence of very dense granul

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00354.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A 15‐year‐old girl with severe factor VII deficiency and chronic arthropathy showed an excessively prolonged bleeding time. Further studies demonstrated low platelet adhesiveness and abnormal platelet aggregation with ADP, collagen and epinephrine. Release of14C‐serotonin was deficient after aggregation with ADP and epinephrine, but was normal with thrombin. Transfusion of plasma or prothrombin complex concentrate resulted in a partial or complete correction of the bleeding time, respectively, but had no effect on in vitro platelet function tests.Both parents and the only sister had factor VII activities of 42 % ‐ 72 % and factor VII antigen levels of 45 % ‐ 66 % of normal and may thus be heterozygotes with respect to factor VII deficiency. All three had normal bleeding times in spite of abnormal in vitro platelet functions.The observations are interpreted to mean that in this family with factor VII deficiency and abnormal platelet release reaction the platelet abnormality as such was not sufficiently severe to prolong the bleeding time unless the factor VII activity was also

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00355.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The absorption of iron from tablets given with 5 types of meals was studied in 153 subjects. The meals were: a hamburger meal with beans and potatoes, a simple breakfast meal, a Latin American meal composed of black beans, rice and maize and two Southeast Asian meals composed of rice, vegetables and spices served with and without fish. The groups were directly compared by relating the absorption from the iron tablets to the absorption from a standardized reference dose of iron given on an empty stomach.The composition of meals with respect to content of meat or fish or the presence of large amounts of phytates seemed to have no influence on the absorption of iron from tablets. The absorption from iron tablets was about 40% higher when they were given with rice meals than when they were given with the other meals studied. The average decrease in absorption by meals was about 50–60 % based on a comparison when‐tablets were given on an empty stomach. When tablets from which the iron was released more slowly were used, the absorption increased by about 30 % except when they were given with rice meals, where the absorption was unchanged. The differences among the meals in their effect on the absorption of iron from tablets thus disappeared when the slow‐release tablets were

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00356.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The distribution of labelled autologous platelets in the myocardium was studied in open‐chest dogs following a nonthrombotic coronary artery occlusion. A significant accumulation of platelets occurred in the ischaemic and borderline ischaetnic myocardium both 15 and 150 min after coronary artery occlusion, most pronounced after 150 min. The small platelet accumulation after 15‐min ischaemia might be due to stasis of blood since a similar increase in labelled erythrocytes in that area was observed. The platelet trapping after 150 min most likely represents platelet aggregates. In spite of the marked increase in platelet trapping, the myocardial blood flow in the ischaemic area increased significantly from 15 to 150 min of myocardial ischaemia. It is concluded that the increased platelet trapping in the first hours following a nonthrombotic coronary artery occlusion was insufficient to impair coronary circulat

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00357.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Morphological and immunological marker data on a patient with ‘pure’ monocytic leukaemia are presented and compared with those of 6 cases of clearly mixed myelo‐monocytic leukaemia with a variable monocytic component. In all patients studied, the leukaemic monocytes expressed a receptor for the Fc of IgG, and IgG sensitization markedly enhanced phagocytosis of ox erythrocytes. A variable, but lower, percentage of the leukaemic monocytes had a receptor for mouse C3, but the cells uniformly lacked surface immunoglobulin and receptors for the Fc of IgM and for unsensitised mouse erythrocytes. Cytochemical and ultrastructural study also showed no clear difference between the monocytes of the ‘pure’ and mixed monocytic leukaemias. This report therefore lends no support to the concept of distinct types of monocytic

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00358.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A patient with metastatic carcinoma of the breast and increased plasma cobalamin binding capacity (about 50 nmol/1) is described. The binding protein was identified as transcobalamin I (TCI) by DEAE cellulose ion‐exchange chromatography, Sephadex G200 gel filtration and agar gel electrophoresis.Although the total plasma cobalamin concentration (about 20 nmol/1) was elevated, the patient complained of neurological symptoms in accordance with a functional vitamin B12deficiency. Hence, an inactivation of the coenzyme is suggested by the demonstration of considerable amounts of 5′‐deoxyadenosylcobalamin bound to the plasma TCI. Both urinary excretion of FIGLU and methylmalonic acid were within the reference ranges.Reported cases of increased cobalamin binding in patients with nonhaematological malignancy are reviewed. Further investigations to characterize the function of the cobalamin dependent metabolic pathways are necessary to determine the importance of the increased transcobalamin binding in these pat

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00359.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The risk of Hodgkin's disease (HD) in young adults is correlated to height. This association indicates an etiologic factor acting during growth.Our aim was to evaluate the importance of growth pattern as a risk factor in HD. The register of records from the school health service of the Copenhagen Council was scrutinized in order to find Danes with HD born between 1930 and 1950. Whenever possible, three matched controls (comparable in respect to socio‐economic status) were selected from the register for each case. The material consisted of 63 cases and 183 controls. Information regarding height, weight and birth weight was obtained from the school health records.The patients were taller than controls at 8, 10, 12 and 14 years of age. The birth weight was available in 33 cases and 99 controls, and was higher in the former (median 3.50 kg) than in the latter (median 3.30 kg) (P<0.01). Our findings suggest the existence of either a risk factor associated with rapid growth or a protective factor connected with slower growth, effective even before birt

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00360.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

In a patient with chronic lymphocytic leukaemia, two M components of the IgGk and IgGλ classes were demonstrated in the serum at the time of diagnosis. The patient was first followed without treatment; after 18 months multiple myeloma developed. At that time, immunofluorescence study of lymphocytes of the peripheral blood showed mainly membrane‐bound immunoglobulins (S‐Ig) of the IgGk class. The bone marrow disclosed a definite predominance of plasma cells with cytoplasmic IgGλ, suggesting that the two B cell‐derived diseases had arisen from two different cell clones.During the development of multiple myeloma, the serum concentration of the M component IgGλ increased. Concurrently, the M component of IgGk gradually disappeared from the serum, and the concentrations of the normal immunoglobulins IgA and IgM declined. Following cytostatic treatment, the concentration of the myeloma‐derived M component IgGλ was halved and simultaneously the M component IgGk reappeared in the serum.To our knowledge, this case is the second reported of chronic lymphocytic leukaemia and multiple myeloma indicating development of the two diseases from different cell clones, and the first reported case with myeloma‐induced suppression of M‐com‐ponent secretion fro

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00361.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY