摘要:

In young adults with Hodgkin's disease, cell mediated immunity (CMI) was evaluated retrospectively from their health records. The register of records from the school health service of the Copenhagen Council was scrutinized in order to find the records of those with HD born between 1930 and 1950 in whom the disease had been diagnosed between 1943 and 1975. Whenever possible, three controls were selected from the register for each case; they were comparable in respect of sex, year and month of birth and socio‐economic background. The material consisted of 63 cases and 182 controls. Information regarding BCG‐vaccinations, tuberculin skin‐tests, the frequency of tuberculosis, bacterial and viral diseases, and of tonsilectomy, adenoidectomy and appendectomy was obtained from the school health records. 2 HD patients have had tuberculosis versus none in the control group. Complications to or prolonged course of viral diseases were reported neither in HD patients nor in controls. No significant differences were found in the frequency of BCG‐vaccination, tuberculin reactivity, viral and bacterial diseases, adenoidectomy, tonsilectomy and appendectomy. Therefore our findings do not support the concept of a pre‐morbid CMI deficiency st

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00363.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A case of erythrocytosis with increased plasma erythropoietin level was reported. Peripheral leucocytes and thrombocytes were normal. No splenomegaly was detected. Studies to find underlying disorders causing increased plasma erythropoietin level and erythrocytosis revealed no abnormalities except for the thickened and tortuous interlobular and afferent arteries in the kidney. This change was suggested as the cause of erythrocytosis found in this case.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00364.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Giant granules were present in the cytoplasm of marrow granulocytes and in abnormal immature leucocytes circulating in the blood of a patient with promyelocytic leukaemia associated with intravascular coagulation. These granules resembled those seen in Chediak‐Higashi syndrom

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00365.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A Wilms' tumour was diagnosed in an 18‐year‐old male patient with erythrocytosis. After radical excision of the tumour and postoperative irradiation and chemotherapy, the erythrocytosis disappeared and did not recur during a 2‐year observation period. The levels of erythropoiesis‐stimulating activity in serum and in the renal mass suggest the tumour as the source of this activity. The rarity of the association is discussed and a review of the literature i

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00366.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A case of Waldenström's macroglobulinaemia with Ig E M‐component was presented. A 76‐year‐old Japanese woman had a history of the operation for mammary carcinoma. Although neither lymphadenopathy nor hepatosplenomegaly was present, the immunohaematological findings typical for Waldenström's macroglobulinaemia were observed in this patient. Coexistence of the Ig M and Ig E M‐components was recognized in the patient's serum protein. Positive reaction for FITC‐conjugated anti‐e or rhodamine‐conjugated anti‐μ was noted in proliferating lymphoplasmacytic cells of the patient's bone marrow, but these reactions were not simultaneously observed in a single cell. The finding suggests that two separate populations of M‐component‐pro‐d

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00367.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

A 73‐year‐old man who had suffered for many years from psoriasis was treated with systemic psoralen and longwave ultraviolet light. After 1 year he developed a pre‐leukaemic condition characterized by a refractory anaemia, a slight thrombocytopenia and a normo‐ to hypercellular bone marrow with an excess of myeloblasts. Karyo‐typing revealed an abnormal chromosome (12p—) and agar cultures of bone marrow showed moderate growth with a high cluster/colony ratio. He died 1 year later of renal failure precipitated by an acute pancreatitis. Owing to the possible causal relationship we would like to advise increased attention to the haematopoietic system of patients treated wi

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00368.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The first case of platelet satellitism to monocytes in a patient with hypogammaglobulinaemia is described. Platelet adherence was observed with heparinized blood and was dependent on the patient's plasma. The ultrastructural findings observed with the transmission (TEM) and scanning electron microscope (SEM) are reported.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00369.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The occurrence of a monoclonal gammopathy followed by IgG‐lambda multiple myeloma is described in a patient receiving diphenylhydantoin therapy for 20 years for epilepsy. Despite the known association between the drug and the development of immunosuppression and lymphoma, we regard the association recorded in this case to be coincidence. It is suggested that periodic examination of the serum proteins in patients receiving the drug may be useful in detecting early aberrations of the immune system in these individual

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00370.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Unseparated as well as nonadherent human bone marrow cells produced colonies while suspended within plasma clots contained within diffusion chambers implanted into irradiated mice. The majority of colonies consisted of granulocytes or macro‐phages. Colony size was significantly increased by the administration of endotoxin prior to implantation of the chamber

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00371.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Granulocyte‐committed progenitor cells (colony‐forming units, CFUc) in the blood of 10 patients with primary myelosclerosis and 2 patients with myelosclerosis following polycythaemia vera were assayed by the agar culture technique. The mean number of CFUc was 54.1 ± 109 (SD) (range 1.4–394) × 106/1 which corresponded to an increase of more than 1000‐fold above normal levels. There was a linear relationship of CFUc with total leucocyte count in the different patients. The magnitude of this increase resembles that found in untreated patients with chronic granulocytic leukaemia and is therefore in keeping with the concept that the concentration of CFUc in the circulation is due to a primary increase in their number and not to disordered release from t

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1978.tb00372.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY