摘要:

10 patients in whom pruritus was a very prominent symptom were treated with levomepromazine in daily doses of 25–50 mg. 7 of these patients suffered from Hodgkin's disease and 3 from reticulum cell sarcoma. In a number of patients levomepromazine controlled pruritus effectively without significant side‐effects. Though all the patients had other simultaneous treatments,e.g.radiation treatment or chemotherapy, the treatment with levomepromazine is considered to be the cause of relief of the pruritus in most of the patie

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1965.tb01283.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

In earlier work Fichtelius (1951) demonstrated a biphasic appearance of labelled lymphocytes in the blood after a single injection of P32as orthophosphate. The second activity increase was at that time explained in three alternative ways: re‐circulation, reutilization or delayed output.This biphasic appearance of labelled lymphocytes in the blood was confirmed in this new study in rabbits using H3‐thymidine. To‐day all three alternative explanations are still possible and more work is needed for a certain interpretation of the second activity peak obs

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1965.tb01284.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

1. Three patients with classic haemophilia presented with a similar intrarenal obstructive pattern. Two of the patients had been treated for idiopathic haematuria. The third patient developed the renal obstructive problem in his post‐operative period.2. The pyelography studies implicate an intrarenal unilateral obstructive mechanism in each patient as cause for abnormality. Intratubular fibrin deposition is suggested as a possibility.3. E‐ACA was being used as a therapeutic endeavor in all these patients and was discontinued just prior to the development of symptoms. The evidence presented suggests that the intrarenal obstruction may be secondary to E‐ACA therapy rather than a complication of the bleeding di

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1965.tb01285.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

A method for histochemical demonstration of Lactate Dehydrogenase in cells in blood films, employing agar for fixation, is described and the findings with normal cells are presented. The effect of PMS in the substrate is briefly discussed.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1965.tb01286.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

An abnormal haemoglobin, observed in a southern Italian family, is described. The electrophoretic and chromatographic behaviour of this haemoglobin is reported. This haemoglobin appears to differ from previously described abnormal haemoglobins and it has thus been named haemoglobin Caserta. The average amount of haemoglobin Caserta present in heterozygotes is 12 per cent. The fingerprinting analysis of haemoglobin Caserta has revealed an alteration, which has tentatively been localized in the “core” region of the β peptide c

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1965.tb01287.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

In chronic myeloid leukaemia the adhesiveness of mature neutrophilic leukocytes to an approximately standardized glass bead column and the phagocytic activity of neutrophils are abnormally low. The distribution of neutrophils with different power of phagocytosis has been investigated in 6 cases of CML. The increasing number of white blood cells characteristic of aggravation of the disease is accompanied by an increasing part of mature neutrophils with low phagocytic activity. Neutrophils with high phagocytic activity do not change their number to any extent in different stages of CML. Nor does this number seem to be significantly higher in CML than in normals. Neutrophils in 3 cases of polycythaemia vera with leukocytosis, 1 case of thrombocythaemia with leukocytosis and 2 cases of32P‐treated polycythaemia vera with signs of acute leukaemia had a high phagocytic activity. One case of myeloproliferative disorder originally diagnosed as polycythaemia vera with certain later signs of CML had a phagocytic pattern similar to that seen in typical cases of CM

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1965.tb01288.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

By immunization of rabbits with isolated γM‐globulin from patients with Waldenström's macroglobulinaemia and absorption with normal serum, an antiserum was obtained (R 112) that precipitated sera from some, but not all, patients with Waldenström's macroglobulinaemia. The antigen was localized to the heavy polypeptide chain of the γM‐globulin molecule. A similar heterogeneity was suggested in normal γM

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1965.tb01289.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

1. The influence of intravenously and intraperitoneally administered cephalin on ADP‐induced thrombosis in the rats was studied. 2. Hypercephalinaemia induced by simultaneous administration of cephalin with the ADP caused a significant increase in thrombosis. 3. The mode of action of phospholipids is discussed and it is concluded that phospholipids can act in thrombosis during the first stage of platelet adhesio

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1965.tb01290.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

A method of in vitro culture of marrow cells with tritiated folic acid is described. Megaloblastic marrow cultures were converted to normoblastic after 18 hours incubation, either with or without additional folic acid. About one per cent of nucleated cells took up the tritium label, either as folic acid or as metabolites. The eosinophil series were labelled more heavily and more frequently than neutrophils. The significance of the results in terms of the metabolism of folic acid is discussed.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1965.tb01291.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY

摘要:

“Families” of closely related, abnormal karyotypes were found in mitoses from bone marrow and cultured leucocytes in four cases of chronic myelogenous leukaemia in the acute stage of the disease. The development of such karyotype families seems to coincide with clinical relapses which are fatal in the course of a few months. It is probable that cells with different karyotypes have different viability in the leukaemic organism. Consequently, in patients treated with cytotoxics, those karyotypes are likely to be selected which are less sensitive to the cytotoxics applied. If this hypothesis is correct, it may contribute to an explanation why patients controlled for years with certain cytotoxic drugs, suddenly grow refractory to these age

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1965.tb01292.x

出版商:Blackwell Publishing Ltd    

年代:1965

数据来源: WILEY