摘要:

50 patients undergoing elective vascular surgery were randomized to prophylactic antibiotic treatment with ampicillin 2 g times; 4 + cloxacillin 1 g times; 4 for 4 d following the operation, or to a control group without antibiotics. All patients received heparin subcutaneously 5000 IU × 2, for 7 d. On days 1 and 4 after the operation, the median bleeding time was 1 1/2‐2 min longer in the antibiotics group. 5 patients on antibiotics had a bleeding time prolongation beyond the normal range, but only 2 of these, who had additional haemostatic defects, had abnormal bleedi

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1983.tb01515.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Normal human monocytes and macrophages, as well as in vitro human leukaemic promyelocytic cell line (HL‐60) transformed into macrophage‐like cells by 12‐0‐tetradecanoyl‐phorbol‐13‐acetate (TPA) generate potent procoagulant activity (PCA) similar to tissue thromboplastin. In the present study, only mild PCA was detected in primary cultures of cells from the peripheral blood of patients with acute lymphatic leukaemia (ALL), acute myeloid leukaemia (AML) and chronic myeloid leukaemia (CML). After exposure to TPA, AML and CML cells assumed characteristics specific to monocytes and macrophages. Differentiation was associated with the generation of PCA. PCA was not found in ALL cells exposed to TPA. The PCA of TPA‐induced macrophages derived from AML and CML cells resembled tissue thromboplastin and normal monocyte and macrophage PCA in several aspects: (a) accelerated clotting via the extrinsic coagulation pathway, (b) inhibition by concanavalin A and protection against lectin inhibition by methyl‐α‐D‐mannopyranoside, (c) localization in the cell membrane. The capacity for PCA generation is additional evidence for the similarity between TPA‐induced macrophages derived from AML and CML cells and normal human m

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1983.tb01516.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Based on the literature and 2 patients studied, we suggest that at least 2 different clinical entities are included in the concept of T CLL: (i) a clinical variant characterized by a relatively benign course, splenomegaly without lymphadenopathy, low lymphocyte count and granulocytopenia; the proliferating lymphocyte is morphologically mature, of medium size and a cytoplasm with azurophilic granules staining positively for acid phosphatase and corresponding to parallel tubular arrays as demonstrated by electron microscopy. The cells form E‐rosettes, have no surface‐membrane‐bound Ig, but Fc‐receptors for IgG. With monoclonal antibodies, the phenotype is OKT3+, OKT4‐and OKT8+, theoretically corresponding to the suppressor/cytotoxic T lymphocyte subset, but functionally the cells demonstrate killer cell (responsible for ADCC), but not natural or suppressor cell activity. (ii) another clinical variant with an aggressive course, massive hepato‐splenomegaly, lymph node enlargement and very high lymphocyte counts; the lymphocytes are small without cytoplasmic granules; their immunological and functional characteristics have not been determined, but morphologically the cells correspond to the T helper/inducer lymphocyte subset. Thus, involvement of different T lymphocyte subsets may be the reason for the clinical variati

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1983.tb01517.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

We present 2 Norwegian siblings who we believe to be the first cases of pyrimidine 5′‐nucleotidase deficiency diagnosed in the Scandinavian countries. In addition to the features presented by previously published cases, our patients exhibited signs of intravascular haemolysis with haemoglobinuria and increased loss of iron in the urine. The loss of iron has made iron medication necessary from time to time. A kidney biopsy from the oldest patient revealed accumulation of iron in the epithelium of the proximal tubuli. The kidneys were considerably enlarged in both patients, but with normal function te

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1983.tb01518.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

3 commonly used parameters for platelet aggregability were tested for their dependence on citrate concentrations. Relatively minor changes in citrate concentrations markedly influenced ADP threshold values for secondary aggregation. Collagen induced platelet malondialdehyde (MDA) production was reduced by increasing the citrate level. This effect was still present in plasma which was also anticoagulated with EDTA. Thrombin induced MDA production was considerably higher in EDTA than in citrate plasma. Citrate appears to inhibit aggregation as well as MDA synthesis. The latter effect does not seem to be solely caused by the effect of citrate on ionized calcium levels.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1983.tb01519.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Granulocyte function was studied in 22 patients with untreated myelomatosis or macro‐globulinaemia. Granulocyte adhesiveness (GA) and migration in capillary tubes (Tm) were, except for light chain disease, significantly decreased in patients of all gammopathy classes especially IgG myelomatosis. A plasma factor inhibited GA. The impairment of Tm was due to an inhibiting factor as well as lack of a stimulating plasma factor. Migration of granulocytes to skin chambers was decreased in patients with IgG myelomatosis. Chemiluminescence production during phagocytosis of opsonized zymosan was decreased. Compared to control sera, the opsonic activity of patient sera was strongly decreased. The impaired granulocyte functions in patients with malignant monoclonal gammopathy may contribute to the enhanced susceptibility to infections in these patient

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1983.tb01521.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A patient with multiple myeloma in whom the bone marrow plasmablasts showed extensive lobulation is described. In addition to numerous lobes, some of the nuclei had a cerebriform appearance, similar to that observed in Sezary cells. The possible relation of this phenomenon to the expression of the altered function of the malignant cells is discussed.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1983.tb01522.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The occurrence of alpha‐heavy chain disease in an Italian adult, working in Libya, is reported, characterized by a spontaneous clinical and immunological recovery. It is suggested that the patient could have acquired the disease during his stay in an endemic area of alpha‐heavy chain disease, and that the observed spontaneous remission could be related to the removal of environmental pathogenic factors, following his departure from Li

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1983.tb01523.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A 25‐year‐old man with myasthenia gravis and a non‐Hodgkin lymphoma stage III B involving the thymus, is reported. The association myasthenia gravis and non‐Hodgkin lymphoma has not been described previously. Treatment with chlormetin, vincristine, procarbazine, prednisone (MOPP) resulted in complete remission of both the myasthenic symptoms and the malignant l

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1983.tb01524.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Zinc levels in plasma and whole blood were investigated in 2 groups of blood donors. The first group consisted of 19 men and 11 women who donated blood for the first time and were followed during 3 phlebotomies. The second group comprised 44 men with 9 or more previous blood donations, their blood being analysed on a single occasion. Plasma concentrations of copper, magnesium, calcium and ferritin were also analysed. The zinc levels in whole blood and plasma in the second group were significantly lower as compared to the first group (P<0.001). Furthermore, the second group had significantly higher levels of copper and copper:zinc quotient in plasma as compared to those of the new blood donors (P<0.001). Our results indicate that besides the earlier known effect of blood donation on iron stores, there are also signs of zinc depletion when judged from the zinc levels in plasma and in erythrocytes. No significant changes in calcium and magnesium concentrations were seen during phlebotomy.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1983.tb01525.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY