摘要:

We describe 4 patients with a haemophagocytic syndrome resembling histiocytic medullary reticulosis (HMR) complicating chronic lymphocytic leukaemia (CLL) of 9 months to 8 years duration. Surface marker studies in 2 cases showed that the CLL lymphocytes were of B‐cell type in one and of T‐cell type in the other. 2 of the patients had histological evidence of co‐existing immunoblastic sarcoma at the time of diagnosis of the HMR‐like syndrome and all 4 patients died within 3 weeks of this diagnosis.The pathogenesis of the HMR‐like syndrome in these patients is discussed and it is concluded that it is probably reactive to an underlying opportunistic viral function related to their immunodepressed state secondary to CLL and/or the cytotoxi

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb01617.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A patient who had primary biliary cirrhosis and, simultaneously, multiple myeloma (IgG, lambda) is reported.In chronic liver diseases, polyclonal hypergammaglobulinaemia is common, monoclonal gammopathies have also been found in rare instances, being attributed to chronic antigenic stimulation of the reticuloendothelial system by antigens from the intestinal flora. The mechanisms (as chronic antigenic stimulation, immunologic disturbances and granulomata formation) which apply to explain the development of monoclonal gammopathies in other conditions are also found in primary biliary cirrhosis. It is postulated that, in this disease, the development of multiple myeloma could be not merely coincidental but also the result of chronic stimulation of the reticuloendothelial system.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb01618.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Surface antigens were analyzed on normal human marrow and chronic myeloid leukaemic cells using 4 monoclonal mouse anti‐human antibodies. The fluorescence‐activated cell sorter was used to quantify the binding of each antibody to different subpopulations of cells, and sorted fractions were cultured in agar‐medium to assay for granulocyte‐macrophage and eosinophil precursors.All cells in the granulocyte series including colony‐forming cells bound a similar quantity of an antibody to the human leucocyte common antigen. This antibody did not bind to cells in the erythroid series. A monoclonal antibody to antigen present on brain, lymphocytes and granulocytes (and almost certainly homologous to the W3/13 antigen of the rat) bound to the cells in the order: blast>promyelocytes and myelocytes>granulocytes. The third monoclonal antibody was directed against a determinant of the leucocyte common antigen present predominantly on B lymphocytes and absent from the myeloid series. The fourth antibody, directed against the human homologue of Thy‐1, reacted with less than 1% of marrow cells, none of which appeared to be granulocyte or eosinophil progenitors. The leucocyte common antigen and the brain‐lymphocyte‐granulocyte‐antigen were also present on colony‐ and cluster‐forming cells from a patient with chronic myeloid leukaemia. Using the low angle and wide angle light scatter properties of CML blood cells, 7‐fold enrichment was obtained for progenitor cells from chronic myeloid leukaemia. With the monoclonal antibodies up to 4‐fol

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb01619.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The in vitro function of granulocytes collected by filtration leukapheresis after premedication of donors with dexamethasone was found to be normal. In vivo studies were performed in a 21‐year‐old woman who was transplanted with allogeneic bone marrow for severe aplastic anaemia. The patient received granulocyte transfusions for treatment of septicaemia during the transplantation period. On 11 consecutive days an average dose of 7.2 times 1010granulocytes/ d was given. Under this therapy remission of fever occurred. On d 6 after bone marrow transplantation, the patient died from cardiac failure. Transfused granulocytes were found ante mortem in a pericardial effusion and post mortem in lungs, kidneys, liver and spleen. The data indicate that filter collected granulocytes function normally in the recipient and are clinically effect

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb01620.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

During routine investigation of plasma proteins by agarose gel electrophoresis, a double fibrinogen band was found in a 79‐year‐old woman without previous history or clinical symptoms of bleeding tendency. The finding was not associated with prolonged thrombin clotting time, and other routine coagulation tests gave normal results. The plasma fibrinogen concentration was normal when assayed as thrombin clottable protein and by immunological methods. The fibrinogen abnormality was not drug‐induced and was apparently unrelated to liver disease. Family studies failed to confirm or exclude its genetic o

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb01621.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Parameters of the cell cycle of lymphoid cells and the rate of production of small lymphocytes and mature plasma cells were estimated in human spleens. 12 normal and 1 enlarged spleen with lymphatic hyperplasia were labelled either by a pulse or continuously with3H‐TdR‐thymidine during normothermic perfusion of the isolated spleens. Biopsies of splenic tissue were taken at different intervals and evaluated autoradiographically. The mean initial labelling index of immunoblasts was 73% and for plasmoblasts 52%. The labelling index for small lymphocytes and mature plasma cells increased initially from 0 % to 1 %, and up to 25 % respectively after 14 h. The duration of the S‐phase, as determined by double labelling, was 8.26 h for lymphoid blasts. Data from the percentage labelled mitosis curve resulted in a minimal tG2of about 1 h and tG2+ tMof about 4 h. The estimated generation time was about 11.5 h. The results found on the hyperplastic spleen were comparable to those on the normal s

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb01622.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Bleeding times were determined in 25 healthy men using the Thrombolette® bleeding time device. The median bleeding times prior to low and high doses of acetylsalicylic acid (ASA), 245 and 230 s, were not significantly different (P = 0.12). 2 h after randomized ingestion of 0.44 and 3.96 g ASA, the median bleeding times rose to 450 and 430 s, respectively. Both increases in bleeding time were significant (P<0.001), but the difference was not significant (P = 0.29). The maximum increase in bleeding time was estimated to occur 2.6 h after ingestion of a single low ASA dose, and 2.4 h after a single high dose. Following ingestion of 0.44 as well as 3.96 g ASA the bleeding time returned to basal levels within 5–6 d. Compared to the younger ones, volunteers with a higher age showed a tendency to have lower plasma salicylate levels as well as smaller increases in bleeding times following ASA ingesti

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb01623.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

In 2 patients with acute promyelocytic leukaemia (APL) an isochromosome for the long arm of chromosome 17 was seen in part of the bone marrow mitoses at diagnosis and relapse, respectively. In one of them, there was a t(15q+;17q‐) affecting one of the No. 15 chromosomes and both arms of the isochromosome. Thus the translocation must have occurred before (or simultaneously with) the formation of the isochromosome. This is the first example of t(15;17) out of 17 patients with APL studied in Finla

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb01624.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Inhalation of nitrous oxide, which inactivates vitamin B12, is followed by a rise in the plasma folate level. The concentration of plasma folate remains elevated throughout the period of exposure to nitrous oxide. Returning the rats to air is followed by a fall to pre‐exposure plasma folate levels within 24

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb01625.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Platelet function was studied in 17 patients with preleukaemia and the results were compared with those of 28 patients with other chronic myeloproliferative disorders. The test pattern included bleeding time (Ivy), platelet retention (Hellem II), PF‐3 activity and availability after exposure to ADP and kaolin, and ADP‐, epinephrine‐, collagen‐ and ristocetin‐induced aggregations. Platelet function was frequently impaired in patients with preleukaemia. The defects were similar to those found in other myeloproliferative disorders. The most consistent finding was defective aggregation. Patients with thrombocytosis and/or with increased amounts of megakaryocytes in the bone marrow had fewer defects in platelet function. Retention defect was more common in patients with hypolobulated megakaryocytes, especially in those having a specific marker, the 5q‐ chromosome, in their bone m

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb01626.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY