摘要:

The case of a 52‐year‐old woman with congenital cyclo‐oxygenase deficiency, signs of generalized atherosclerosis and a moderate bleeding tendency is reported. Secondary platelet aggregation was absent. Platelet aggregation induced by arachidonic acid failed totally while that induced by calcium ionophore was normal. No malondialdehyde formation could be detected in her platelet‐rich‐plasma. The life‐long deficiency of cyclo‐oxygenase had not protected her from progressive vascular disease. This case suggests that the chronic intake of large doses of aspirin cannot prevent arter

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb00453.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A patient with dermoid cyst of the ovary and erythrocytosis is described. Surgical removal of the tumour was followed by a progressive decrease of the red cell mass with remission of the haematological abnormalities. Tumour fluid contained significant erythropoietic stimulating activity. This seems to be the first documented case of erythrocytosis associated with ovarian cyst.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb00454.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Candidal pericarditis is extremely rare. Its clinical diagnosis and successful treatment has not been reported earlier.A case is reported of a 30‐year‐old male with acute lymphoblastic leukaemia complicated with exudative pleuropericarditis, probably initially of leukaemic origin. Following persisting fever cultures of blood and pericardial fluid yielded massive growth of candida albicans.After 3 weeks treatment with intravenous amphotericin B, flucytosine and miconazole, the blood and pericardial fluid was sterilized.A sufficient amphotericin B concentration in the pericardial fluid was obtained without local instillat

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb00455.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Human blood monocytes were separated by centrifugation over modified Ficoll‐Hypaque and by this one‐step procedure relatively high proportions (mean 54%) and yields of monocytes were obtained. Yields ranged from 0.22 times 109to 0.98 times 109/1 of blood and averaged 2 1/2 times the theoretical maximum yield calculated from the blood leucocyte and differential counts. A range of tests of monocyte function are described, namely, adhesion to glass, spreading on glass, chemotaxis under agarose and phagocytosis and killing of Candida albicans. These tests are generally simpler to perform than similar tests previously described and give very reproducible results which compare well with those reported by others. Normal values from 35 healthy Chinese adults are recor

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb00456.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A prospective, comparative study of cytochemical and immunological markers and clinical features was undertaken in 44 patients with ALL (children and adults). 12 patients (27%) had T‐ALL, 1 patient (2%) B‐ALL and 31 patients (71%) (non‐T, non‐B)‐ALL. E‐rosetting lymphoblasts ranged from 35 to 96% (median: 61), highest when AET‐treated SRBC were used as indicator cells. All 12 E‐rosette positive cases were strongly acid phosphatase (AcP)‐positive, showing a homogeneous pattern of distinct granular AcP‐activity in more than 85 % of the lymphoblasts (median: 96 %) significantly different from the median of 26 % granulated blasts found in the (non‐T, non‐B)‐ALL cases. Counting blasts with granular AcP‐activity proved to be both easier than using a scoring system for the AcP‐reaction and more efficient in terms of discriminating ability between the subgroups. Significant clinical and haematological features characterizing the T‐ and AcP‐positive cases included: (1) Predominance of young adult men, (2) presence of a mediastinal mass, (3) involvement of skin and serous membranes, (4) only slightly affected haemoglobin concentration at presentation, (5) difficulty in obtaining complete remission, (6) shorter duration of first complete remission and (7) shorter survival rate. It is confirmed that AcP‐staining of lymphoblasts is an easy, reproducible and inexpensive method for id

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb00457.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

During a 4‐year period 24 cases of malignant non‐Hodgkin's lymphomas were proposed to be of the Burkitt‐type (BL) by at least 1 of 5 pathologists of the Lymphoma Registry in Jutland, Denmark. When the histological material was critically reviewed the diagnosis could be maintained in only 13 cases. 9 of the remaining 11 cases were immunoblastic lymphomas (IBL). Immunohistochemical stainings for cytoplasmic Ig‐chains revealed generally weak reactions in the cases of BL. A distinct B‐zone homing phenomenon first appearing in the lymphocytic mantle zone was observed in several lymph nodes from 2 patients with BL. In the BL‐group the correlation between initial clinical stage and survival was satisfactory, the 2‐year survival rate being 38 % in the total BL‐group. The incidence of BL was 2.1 % of the malignant non‐Hodgkin's lymphoma

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb00458.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Erythrocyte 2,3‐diphosphoglycerate (2,3‐DPG) and adenosine triphosphate (ATP) were measured in 16 patients with polycythaemia vera and found to be normal.The determination of erythrocyte organic phosphate concentration can be helpful in the differential diagnosis of different types of polycythaemia due to the lack of 2,3‐DPG rise in patients with polycythaemia vera, as compared to the 2,3‐DPG increase usually observed in patients with secondary polycy

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb00459.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A series of spontaneous changes affecting the nature of the immunoglobulin secretion of plasma cells is described in a patient initially diagnosed as IgG lambda benign monoclonal gammopathy. After several years a slight increase in the amount of serum monoclonal immunoglobulin occurred; shortly thereafter an aggressive form of multiple myeloma was diagnosed. Unexpectedly a rapid spontaneous decrease of the monoclonal immunoglobulin, accompanied by the appearance in the serum of increasing quantities of a complex containing intact lambda light chains, then occurred. Concomitantly a fragment of the corresponding free light chain was detected in the urine.A parallel is drawn between the facts observed in this patient and in an animal model recently proposed to explain the different types of structural immunoglobulin abnormalities in multiple myeloma.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb00460.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

13 patients with the 5q— chromosome are described. In 6 patients the 5q— chromosome was the sole aberration. 10 patients had preleukaemia, 1 a preleukaemia‐like syndrome after treatment of polycythaemia vera, a 2 acute myeloid leukaemia. The prognosis was especially poor in terms of survival in preleukaemic patients with 3 or more affected chromosomes: none of these 6 patients survived for more than 6 months. In 4 patients the haematological picture resembled ‘the 5q—syndrome’. In the long arm of chromosome No 5 deletions of 3 different kinds were detected. They were named according to the size of the 5q— marker: the short type (10 patients), the intermediate type (1 patient) and the long type (2 patients). There was no clear correlation between the clinical picture and the type of deletion. While the break points cannot always be exactly defined, our data and those reviewed from the literature suggest that the loss of a segment of regions 5q2 or 5q3 is common to all or m

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb00461.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The concentration of HbF and the number of HbF containing cells as measured by the sensitive fluorescent antiHbF antibody technique have been evaluated in 65 patients with treated and untreated thyroid dysfunction. The mean HbF concentration and mean percentage of F‐cells were both found to be significantly greater in untreated thyrotoxic patients than in those with treated thyrotoxicosis and treated or untreated hypothyroidism. The clinical relevance of these observations and their explanation by the modulating influence of thyroid hormones on erythropoiesis and Hb synthesis are briefly discusse

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1981.tb00462.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY