摘要:

A simple and rapid method for evaluation of activator activity in patients during thrombolytic therapy‐the activator time‐is presented. It is based upon a clot lysis system with an euglobulin solution from normal plasma as substrate, but fibrinogen could also be used. The method may tell whether the patient is sufficiently treated or not, and the possibility of establishing a therapeutical range is sugges

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1969.tb02401.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

Red cell ATP levels were determined on the fresh blood of 58 normal subjects using an enzymic method. Values were obtained in the range 80 to 140 μmoles of ATP per 100 ml. of packed red cells.Conditions for obtaining reliable fresh blood ATP values are reported together with the effects of different anticoagulants.It was confirmed that red cellATPis pH‐sensitive. Thus, at pH values below 7.6–7.7 (25° C.) it was stable but at values above this range it disappeared from the red cells. Kinetic studies of red cell ATP at different temperatures and pH values are desc

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1969.tb02402.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

The aggregation of blood platelets occurs in two phases. Primary clumping results from the action of aggregating agents on cell membranes, and the second wave is caused by adenosine diphosphate and catacholamines released from platelets. Several groups of drugs have been described which specifically inhibit the second wave of aggregation. The present report has explored the influence of atropine on platelet structure and physiology. Atropine had no effect on platelet fine structure, but inhibited the second wave of aggregation produced in citrate platelet rich plasma by small concentrations of adenosine diphosphate and epinephrine. In contrast to other agents which block secondary aggregation, atropine also prevents clot retraction. A possible basis for the action of atropine on platelets is discussed.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1969.tb02403.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

A histochemical method for demonstrating aryl sulphatase activity in haemic cells has been applied to 22 cases of leukæmia of different types. The difference in distribution of activity in myeloid and lymhatic cells, which has been suggested as an aid in the classification of acute leukæmias, has not been confirme

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1969.tb02404.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

A report is given of a hereditary bleeding disorder characterized by thrombocytopenia and excessively prolonged bleeding time.The disorder was inherited as an autosomal dominant trait, and segregated independently of the ABO, Rh, MNSs and Duffy blood group systems, and probably of the ABH secretor genes.The patients' own platelets had a shortened survival in the patients' own circulation, indicating an increased destruction. The increased destruction was not due to an intrinsic defect of the patients' platelets, because the platelets survived normally when transfused to a normal recipient. The patients must therefore have some factor or mechanism in their blood or vascular system which shortens the life‐span of their own platelets as well as that of transfused normal platelets.Another striking finding was the unproportionate increase of the bleeding time. The moderately reduced platelet count and normal AHG exclude von Willebrand's disease. The presently reported bleeding disorder did not show the characteristics of the thrombasthenic or the thrombopathic group of disorders.The presently reported haemorrhagic disorder does not fit into any of the previously described one

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1969.tb02405.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

The influence of female sex hormones on leucocyte glycogen and leucocyte alkaline phosphatase (LAP) was studied. Leucocyte glycogen was measured with the anthrone reagent on suspensions of peripheral blood leucocytes containing chiefly neutrophiles. LAP was measured histochemically. Normal adult pre‐menopausal females were shown to have significantly greater leucocyte glycogen levels and LAP score than males. Post‐menopausal females had intermediate glycogen levels and no elevation of LAP. During the menstrual cycle, there was a slight rise of leucocyte glycogen and LAP in the midportion of the cycle. In pregnancy LAP rose significantly above normal in the fourth month and leucocyte glycogen in the sixth month. Both had returned to normal 6 weeks after delivery. Leucocytes from cord blood of newborns had elevated LAP scores but normal glycogen levels. In normal females on anovulatory drugs LAP was elevated while leucocyte glycogen was normal. Patients receiving estrogens therapeutically for prostatic carcinoma had significant elevations of both leucocyte glycogen and LAP while similar patients not receiving estrogens had normal values.The results show that female sex hormones, specifically estrogens, can result in elevation of both leucocyte glycogen and

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1969.tb02406.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

Studies on serum iron and total iron binding capacity were performed in 27 cases of acute leukaemia, 14 cases of other malignant diseases, 10 cases of severe infections and 30 normal controls. All were children. Serum iron values above 70 μ. per 100 ml. were found in 25 of the 27 cases of leukaemia, while all the 14 cases of other malignant diseases and the 10 cases of infections had serum iron below that limit. Higher serum iron values were found in acute leukaemia than in the control group. Total iron binding capacity seems to be slightly reduced in acute leukaemia, while hypotransferrinaemia was a frequent finding in other malignant diseases and severe infections. The diagnostic implications of these findings are discussed

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1969.tb02407.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

The oxalate‐induced nuclear hypersegmentation in neutrophils may be recorded by counting the segments. In heparinized blood, the number of segments remains fairly constant during incubation at 37° C. for at least 6 hours. Temperature depression and demecolcine decrease the number of segments recorded. Under identical experimental conditions, the formation of radial‐segmented (RS) nuclei in mononucleated blood cells is promoted by incubation at room temperature and inhibited by treatment with demecolcine. Cold (+4° C.) and demecolcine at room temperature induce segmental clumping in the nuclei of neutrophils. The possible role of cytoplasmic microtubules in neutrophil segmentation is disc

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1969.tb02408.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

The HD receptors of human erythrocytes, which are demonstrable by HD cold auto antibodies and can be inactivated by both neuraminidase and proteases, are heterogenous. Whereas the HD1receptor was found exclusively on human erythrocytes, the HD2receptor could be demonstrated on human as well as on rat and guinea‐pig erythrocytes. As neuraminidase has been shown to be the ‘specific’ enzyme for inactivating both the HD1and HD2receptors it can be concluded that also the configuration of the neuraminic acid as the HD determinant must be different. The special position of the HD receptor complex in comparison to other receptors determined by neuraminic acid is str

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1969.tb02409.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

A clinical series of 40 patients was observed for 5 months, in the course of which every patient took 1.5 g. metformin daily for 3 months. No increase in fibrinolytic activity was demonstrable by euglobulin lysis test during the course of treatment. Nor did the fibrinogen and cholesterol values change. Blood glucose decreased.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1969.tb02410.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY