摘要:

Griseofulvin inhibited the chemotaxis of polymorphonuclear leucocytes (PMNs) in vitro in the concentration range 0.1‐1.0 μg/ml, i.e. at concentrations comparable to those obtained in serum during peroral treatment with griseofulvin. It is suggested that PMN chemotaxis is inhibited by griseofulvin interference with the redistribution of cytoplasmic microtubules, which is thought to be essential in the direction‐finding of PMNs during chemotaxis. Furthermore, it is suggested that the griseofulvin inhibition of PMN chemotaxis ‐ together with the previously known pharmacodynamic properties of griseofulvin ‐ may provide the rationale for griseofulvin therapy in PMN‐mediated tissue injury

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1975.tb01058.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The ATP‐ase activity was determined in lymphocytes isolated from peripheral blood in 41 patients with Hodgkin's disease and 50 healthy controls. All patients were previously treated with irradiation or cytostatic drugs and 17 patients were under maintenance therapy at the time of investigation. A significantly increased ATP‐ase activity was found in lymphocytes from patients with Hodgkin's disease. The individual activities were unrelated to the clinical stage of the disease, but correlated to the histological classification of the lymphatic tissue. Significantly lower lymphocyte ATP‐ase activity was found in patients under maintenance treatment with immunosuppressive drugs, especially if the patients had previously been irradiated. It is suggested that the ATP‐ase activity of circulating lymphocytes is related to the immunological activity against the presence of the malignant cells in Hodgkin's

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1975.tb01059.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

ADP‐induced aggregation was determined at various times of incubation with ADP in unstirred human platelet rich plasma (PRP) to which adenosine deaminase was added. In the early stages of incubation the shape change response was absent, the aggregation response was poor, and not reversible. These three parameters returned slowly towards normal as the incubation proceeded. Pronounced impairment of the aggregation response was present after all added ADP had been degraded in plasma. Log dose‐response (rate of aggregation) curves for the platelets incubated with ADP had shifted to higher ADP concentrations and had also a small decrease in maximal height and in the slope compared to those obtained with control platelets. However, the shift in log dose response to higher ADP concentrations was far more striking, so the increase in log dose (R) necessary to obtain the same rate of aggregation as with control PRP was taken as a measure of refractoriness of aggregation towards ADP. R increased with the time of incubation to an optimal value and then decreased. The magnitude of the optimal value and the time at which optimum was reached increased with the concentration of the ADP incubated with the platelets. The variations in R during incubation did not correlate with the breakdown of added ADP. The platelets began to recover their ability to aggregate with ADP while there was still ADP in the sys

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1975.tb01060.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The bone marrow was examined on material obtained with the Gidlund trephine and with conventional cytologic bone marrow aspiration in 225 patients with malignant disease, 144 of whom had malignant lymphoma, and in 5 patients with haematological, non‐malignant disease. With Gidlund's instrument, the malignant disease was found to engage the bone marrow in 35 cases as compared to 7 cases with needle biopsy. No complications were met with either technique. Bone marrow biopsy was routinely performed in the out‐patient departm

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1975.tb01061.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

B‐, T‐ and O‐lymphocytes detected as EAC‐, E‐ and non‐rosette forming lymphocytes were investigated in venous blood in 49 patients with connective tissue diseases, psoriasis and chronic lymphogenous leukaemia (CLL) during treatment with either prednisone alone, prednisone and cytostatic agents or cytostatic agents alone. Prednisone alone did not change the B‐, T‐ and O‐lymphocyte counts. Cytostatics alone or in combination with prednisone reduced the B‐ and T‐lymphocyte counts concomitant with a significant increase in the O‐lymphocyte count. The findings could be explained by assuming that cytostatics disturb the immunological functions of the lymphocytes and finally deprive the cells of their B‐ and T‐markers. The optimal immunosuppressive treatment with cytostatic agents may be associated with a certain reduction of B‐ and T‐lymphocytes which may be

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1975.tb01062.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

A family survey was conducted among 909 patients with leukaemia of all types, with the purpose of establishing the incidence of further cases of leukaemia among relatives.Among a total of 41,807 relatives 8,349 were deceased, and the cause of death was objectively confirmed in 5,011.72 patients had one or more relatives with leukaemia. First degree relatives with leukaemia were much more frequent in families of patients with chronic lymphocytic than in those of patients with chronic granulocytic leukaemia.The incidence of leukaemia among first degree relatives was established to be 2.8‐3.0 times, among more distant relatives about 2.3 times, and overall about 2.5 times that expected. This excess is of the order of that observed in relatives of patients with certain solid tumors.Genetic factors may have accounted for much of the excess incidence in chronic lymphocytic and acute leukaemia, but there was little evidence for a genetic background in chronic granulocytic leukaemia.With the possible exception of one family with muitiple cases, a simple Mendelian mechanism did not appear to be involved in the leukaemia families investigated. It appeared more likely that a polygenic mechanism led to a heightened susceptibility to the disease in these familie

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1975.tb01063.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Hypercalcaemia developed in a patient with chronic lymphatic leukaemia. The hypercalcaemia did not respond to conventional treatment. At bone biopsy osteoclastic resorption was found (a photomicrograph is presented). 7 cases from the literature of hypercalcaemia and chronic lymphatic leukaemia are briefly reviewed. Possible mechanisms are discussed and it is suggested that osteoclast‐stimulating factors may be of importance in the development of the hypercalcaemi

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1975.tb01064.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

The thymidine kinase activity per 106DNA‐synthesising marrow cells and the rate of incorporation of tritiated thymidine into the DNA of 103DNA‐synthesising marrow cells were estimated in 9 haematologically normal patients and 49 patients suffering from a variety of haematological disorders. Slight increases in thymidine kinase activity were found in 6 of the 31 patients with haematological diseases associated with normoblastic erythropoiesis and greater increases were found in 3 of the 18 patients with megaloblastic haemopoiesis due to vitamin B12or folate deficiency. In the latter group, there was a statistically significant inverse correlation between haemoglobin levels and thymidine kinase activity. No correlation was found between thymidine kinase activity and the rate of incorporation of tritiated thymidine in either the normoblastic or megaloblastic group, suggesting that the level of thymidine kinase activity does not limit the rate of incorporation of exogenously supplied thymidine into the DNA of human bone marrow ce

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1975.tb01065.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Severe red cell glucose‐6‐phosphate dehydrogenase (G‐6‐PD) deficiency has been found in an ‘aboriginal’ Finnish family. 2 male and 9 female carriers of the variant G‐6‐PD were studied. The genetic pattern is consistent with x‐linked recessive inheritance and the defect is associated with drug (primaquine) induced haemolysis. This was demonstrated by enzyme deficient red cell (51Cr‐labelled) survival studies on a normal volunteer recipient. In addition, one of the hemizygotes studied had a slight chronic nonspherocytic haemolytic disorder. The partially purified enzyme had many of the characteristics of G‐6‐PD Mediterranean. The occurrence of this G‐6‐PD Mediterranean type variant in the Finnish population, which differs greatly from Mediterranean ethnic groups, as well as the association of slight chronic haemolysis with severe G

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1975.tb01066.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Book reviewed in this article:M. O'Connor&F. P. Woodford (1975) Writing Scientific Papers in EnglishN. R. Ling&J. E. Kay (1975) Lymphocyte Stimulation (2nd ed)G. Cohnen (1975) T‐ und B‐Lymphozyten bei chronischer lymphatischer Leukämie und Lymphogranulom

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1975.tb01067.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY