摘要:

In 42 patients splenectomized after injury of the spleen or for non‐malignant diseases residual splenic tissue was detected by99mTc scanning in 19 (Group I) and not detected in 23 (Group II). Autoantibodies detected by the indirect immunofluorescent method occurred in 16 (38%) of the splenectomized patients and in 6 (14%) of 42 age‐ and sex‐matched controls (P<0.02). In patients with residual splenic tissue the incidence of autoantibodies did not differ significantly from that in the controls, whereas autoantibodies occurred significantly more often in patients without residual splenic tissue (39%) than in the corresponding control group (9%) (P = 0.016). Antibodies to nuclear antigens (ANA), smooth muscle (SMA), reticulin (RetA) and cytoplasm of gastric parietal cells (PA) were detected, and the antibody titres tended to be higher in the patients than in the controls. None of the patients showed any clinical signs of autoimmune disease. These findings indicate that splenectomy disturbs the regulation of autoantibody function, and it is possible that this might be caused by a reduction of the number of T suppressor cells for which the spleen is a major pool. It is suggested that residual splenic tissue may prevent an increased occurrence of autoantibodies in splenectomized pat

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb00526.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

A patient with congenital dysterythropoietic anemia was described in 1975 as variant type II because of negative acidified lysis tests using 12 different fresh sera. Subsequent tests with 2 additional normal sera have been strongly positive.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb00527.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Among 2014 apparently healthy men aged 40–59 years platelet function was studied with Hellem's retention method in 488 men. In 55 of these 488 men coronary heart disease (CHD) was strongly suspected and coronary angiography confirmed the diagnosis in 34 of 51 angiographied men. Platelet responsiveness was significantly lower among those who had angina pectoris than among their CHD‐suspect counterparts without angina, regardless of coronary angiographic findings. Since angiopositive men without angina and 408 ‘normals’ had similar retention values, it seems as if presenting symptoms, but not the development of CHD are linked to platelet function. During a near maximal bicycle exercise test significantly higher peak exercise blood pressure was found among men with very low retention values than among men with rention values in the middle and upper range. This could not be explained by differences in maximal heart rate or work performance. This indicates that blood pressure regulation during exercise may in part be linked to platelet function related mec

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb00528.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

5‐formyltetrahydrofolate and tetrahydrofolate were added to marrow cells from patients with untreated pernicious anaemia at 1, 5 and 50 nmol doses in the deoxyuridine suppression test. At all 3 dose levels formyltetrahydrofolate was significantly more effective in correcting the defect of thymidine synthesis in pernicious anaemia, than tetrahydrofolate. The data suggest that formylation of tetrahydrofolate is necessary for its normal utilizatio

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb00529.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The distribution of T‐cell subsets has been examined in cell suspensions from lymph node biopsies from 37 non‐Hodgkin lymphomas (NHL) of B‐cell origin and 8 cases of Hodgkin's disease (HD). T‐inducer/helper cells (T4+cells) and T‐suppressor/cytotoxic cells (T8+cells) were identified by the monoclonal antibodies OKT4 and OKT8, respectively. Compared with reactive lymph nodes the T‐cell subset distribution was aberrant in 18/37 (48.6%) of the B‐cell lymphomas. The T‐suppressor subset was dominating cells in 14/37 (37.8%) and the T‐helper subset in 4/37 (10.8%) of the cases examined. In patients with leukaemic disease, a concordant T‐cell subset distribution in lymph nodes and PBL was observed in 5 out of 6 cases.HLA‐DR antigen was examined in a selected number of cases with a heteroantiserum. In general, the T‐cells from neoplastic tissues expressed an increased percentage of HLA‐DR antigen. This was most pronounced in cases with a dominance of T8+cells, in which the majority of T8+cells expressed HLA‐DR antigen. These findings suggest that an increased proportion of activated T‐suppressor cells are present in a proportion of B‐cell lymphomas. Possible clinical and biolog

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb00530.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

A patient with sideroblastic anaemia and hereditary persistence of foetal Hb was examined for acetylcholinesterase (Ache) type and i antigen. Ache electrophoresis showed a mobility intermediate between adult and foetal blood; i antigen was of foetal type.

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb00531.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The serum concentration of free kappa and lambda light chains of immunoglobulins was measured in 114 patients with myelo‐ and lymphoproliferative disorders including multiple myeloma. Increased concentrations of a single light chain type, suggesting monoclonal origin, were found with high frequency in B‐cell diseases only. Thus 6 out of 9 patients with chronic lymphatic leukaemia and 24 of 28 patients with multiple myeloma had increased concentrations of a single chain type. The highest values reported in chronic lymphatic leukaemia were approximately 10 and in multiple myeloma 1000 times normal mean. Cytostatic treatment of chronic lymphatic leukaemia was followed by a decrease in the light chain levels. The levels were, however, not correlated to the number of circulating lymphocytes, the lymphatic infiltration of tissue or clinical activity. Increased concentrations of both chain types, suggesting a polyclonal origin, were found in both of 2 patients with acute monocytic leukaemia, 6 of 7 with acute myelomonocytic leukaemia, 2 of 23 with acute myeloid leukaemia and 1 of 7 with acute lymphoblastic leukaemia. The highest levels of light chains in these groups were 5 times normal mean. All patients with myeloproliferative disorders revealed normal values of both light chain ty

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb00532.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

In 357 thrombocytopenic patients, the autoimmune nature of the thrombocytopenia was established with the immunofluorescence test on paraformaldehyde‐fixed platelets in suspension (PSIFT). In 142 patients, autoimmune thrombocytopenia (AITP) was accompanied by (an)other disease(s) and thus classified as secondary AITP. No significant difference was found in the distribution of the immunochemical characteristics of the autoantibodies between primary and secondary AITP.The results of survival studies with51Cr‐labelled platelets and organ sequestration measurements in 7 patients with idiopathic thrombocytopenia purpura (ITP) indicated that platelets with IgM autoantibodies were sequestered mainly in the spleen. An increased incidence of AITP was seen at 5 to 10 years of age, in the 3rd decade and in the 6th and 7th decades of life. AITP was slightly more common in females. The following groups of accompanying diseases in 142 AITP patients were distinguished: autoimmune diseases of the blood, malignant diseases of the blood, generalized and organ‐specific autoimmune diseases, carcinoma and a miscellaneous group of diseases. No significant differences were found in the immunochemical properties of the autoantibodies between the various categories of disease. In 7 cases, AITP was preceded by an established viral disease, in 1 case by lepra and in another by a vaccination. The PSIFT was found to be a suitable test for diagnosing AITP not only in idiopathic thrombocytopenia, but also in thrombocytopenia associated with another di

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb00533.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The lymphoid component of skin infiltrates from 6 cases of mycosis fungoides and 2 cases of T cell chronic lymphatic leukaemia consisted almost exclusively of T lymphocytes with abnormally high E receptor expression. Such T cells were also found to dominate the skin infiltrates from 10 patients with severe atopic dermatitis. Blood T lymphocyte counts from all types of patients were within the normal range, but even the blood T lymphocytes of the patients had a strong E receptor expression. The bone marrow in atopic dermatitis and in mycosis fungoides showed normal T cell counts with normal E receptor expression. Supported by basic lymphocyte‐kinetic considerations it is likely that the skin in T lymphoproliferative diseases is characterized by an abnormal ability to home and/or to trap T lymphocytes with strong E receptor expressio

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb00534.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

13 patients with adult non‐lymphocytic leukemia (ANLL) who developed central nervous system (CNS) involvement during the course of their illness are reported and compared with a control group of 26 ANLL patients without CNS involvement. The incidence of CNS involvement was 13/510 patients (2.5%). Initial symptoms and signs and routine laboratory data were not helpful in predicting which patients would ultimately develop CNS involvement. Almost 1/2 of the patients were in clinical and haematological remission at the time of the diagnosis of CNS involvement. Specific treatment to the CNS including intrathecal cytotoxic drugs and/or radiotherapy failed to increase the survival rate significantly. Whether the establishment of an early diagnosis of CNS involvement and the institution of appropriate treatment may improve the prognosis of this complication is a question which presently remains unanswere

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1982.tb00535.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY