ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb00342.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb00343.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb00344.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb00345.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb00346.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe correlation between the magnitude of the increase of serum iron after an oral dose of iron and the total absorption of iron was studied in 51 healthy subjects and 10 patients with iron deficiency anaemia.59Fe‐labelled solutions of ferrous sulphate (25–100 mg iron) were administered to the fasting subjects. The serum iron concentration was followed for 4–6 hours and the absorption was measured in a whole‐body counter.Good correlation was found between the maximal increase of serum iron and the total amount of iron absorbed after a dose of iron given as a solution. The serum iron method may be used for comparisons of the absorbability of different doses of iron by performing cross‐over studies in groups of subjects. However, it was found that in an individual subject the serum iron method could not be used to determine the amount of iron absorbed from an oral dos

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb00347.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe absorption of iron from three different iron tablets ‐ rapidly‐disintegrating ferrous sulphate and ferrous carbonate tablets and slow‐release ferrous sulphate tablets ‐ was studied in healthy subjects with a serum iron technique and by whole‐body counter measurements. A solution of ferrous sulphate was used as a reference. There were no differences in the absorption from the ferrous sulphate preparations, but the ferrous carbonate tablets were less well absorbed. Good correlation was found between the maximal serum iron response and the total absorption of iron and it was concluded that serum iron studies may be used for semiquantitative measurements of iron absorption in comparative studies on different iron pre

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb00348.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe influence of a liquid antacid on the absorption of iron from iron tablets was studied in healthy volunteers using a serum iron technique. Tablets containing ferrous salts (carbonate, fumarate, sulphate) with different in‐vitro dissolution properties were studied. Co‐administration of the antacid and the iron tablets resulted in a marked reduction of the absorption of iron from all preparations studied. The lowest absorption was found when ferrous carbonate was given with the antacid. This was ascribed to the fact that ferrous carbonate is almost completely insoluble at pH‐levels near neutral. This was confirmed in a series of patients with achlorhydria in which the absorption from ferrous carbonate was virtually nil. It was concluded that iron tablets and antacid preparations should not be administered at the same time and that ferrous carbonate tablets should not be used in patients with achlorh

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb00349.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe influence of a standardized breakfast meal on the absorption of iron from two types of iron tablets ‐ rapidly‐disintegrating and slow‐release tablets ‐ was studied in 24 healthy subjects, using a serum iron technique and whole‐body counter measurements. The meal markedly reduced the absorption of iron from both types of tablets. An 8‐fold reduction was found with the rapidly‐disintegrating tablets and a 3‐fold reduction with the slow‐release tablets. Under fasting conditions the rapidly‐disintegrating tablets were significantly better absorbed than the slow‐release tablets, whereas the reverse was found when the tablets wer

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb00350.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe absorption of iron from slow‐release and rapidly‐disintegrating ferrous sulphate tablets has been compared using a double radioiron isotope technique. The studies were performed in 15 normal subjects, 20 blood donors and 10 patients with iron deficiency anaemia. The preparations containing 100 mg of ferrous iron were given twice daily on alternate days for 10 days. The absorption differed significantly between the three groups of subjects, being highest in the anaemic patients and lowest in the normal subjects. In all groups, significantly more iron was absorbed from the slow‐release tablets compared to the rapidly‐disintegrating tablets. The mean absorption ratios were 1.3 in both normal subjects and blood donors. In patients with iron deficiency anaemia the ratio

ISSN:0036-553X    

DOI:10.1111/j.1600-0609.1976.tb00351.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY