ISSN:0192-0790    

出版商:OVID    

年代:1980

数据来源: OVID

ISSN:0192-0790    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

Of approximately 400 patients with ulcerative colitis admitted to the Mount Sinai Hospital in New York City during 1970–1978, five developed acute myelogenous leukemia in the course of their illness. This association may be more than fortuitous.

ISSN:0192-0790    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

An immediate hypersensitivity reaction with mast cell degranulation may be of importance in the pathogenesis of ulcerative colitis. Cromolyn sodium stabilizes the mast cell membrane, and thus could have potential benefit in the treatment of this disease. The few clinical studies published to date are difficult to interpret, and have not established the therapeutic benefit of cromolyn sodium in ulcerative colitis.

ISSN:0192-0790    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

We report a retrospective review of the pertinent clinical, endoscopic, and radiologic findings of 15 patients with vascular ectasia of the colon. Although the majority of the patients were over 60 years old, 40% were older than 50 but younger than 60. Vascular ectasia can occur without associated aortic stenosis or chronic obstructing pulmonary disease. Twenty-seven percent of the patients had multiple lesions involving the transverse or descending colon or both, as well as the cecal-ascending colon area. Colonoscopy and angiography were able to detect the vascular ectasia, but both diagnostic methods missing some lesions. Watchful waiting appears to offer a reasonable approach toward patients with vascular ectasia of the colon unless the lesions cause significant or recurrent bleeding.

ISSN:0192-0790    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

We examined 27 patients with portal hypertension admitted because of acute UGI bleeding endoscopically within 24 hours. We identified esophageal-gastric varices as the bleeding source in 22 patients, and found no acute mucosal lesions in any of them. In only four patients was chronic liver disease due to alcohol consumption. We therefore suggest that acute mucosal lesions as a cause of UGI bleeding in patients with portal hypertension are common only in those with alcoholic cirrhosis.

ISSN:0192-0790    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

Basal and histalog-stimulated gastric acid secretion and serum gastrin levels before and after a standard protein meal were compared in eight children with active duodenal ulcer (DU), four with active gastric ulcer (GU), and in seven children with recurrent abdominal pain (RAP) of undetermined etiology. There was no discernible difference in the pattern of abdominal pain in DU, GU, and RAP. Basal acid output, peak and maximal acid output, whether expressed as mil-liequivalents per hour or as milliequivalents per kilogram per hour, were comparable in children with DU, GU, and RAP. In contrast, serum gastrin levels, 1 and 2 hours after standard protein meal, were significantly higher in the DU children than in the GU or RAP group. These studies have suggested that hypersecretion of gastric acid may not be associated with duodenal ulcer or gastric ulcer disease in children, and that increased gastrin secretion and possible reduced acid responsiveness coexist in children with duodenal ulcers.

ISSN:0192-0790    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

Severe motor abnormalities in the human esophagus injured by acid correlated with the degree of mucosal esophageal damage observed by esophagoscopy. In mild caustic esophagitis, motor function remained normal. In severe esophagitis, motor alterations included decrease or absence of high resting pressure in the lower esophageal sphincter with normal swallowing response. In the body of the esophagus, manometric findings were variable and consisted of high resting esophageal pressure, absence of motor response after swallowing, nonperistaltic contraction, and delayed swallowing response. At follow-up motility studies 1 month after injury, esophageal motor function had returned to normal. We suggest that these abnormalties, which could be related to edema or a transient damage of mucosal sensory nerves, contributed to dysphagia.

ISSN:0192-0790    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

Whether prolonged cholestasis is followed by hepatic rrhosis is still controversial. We have studied two unrelated Children who have had cholestasis for 15 years, but neither whom have developed cirrhosis. Both have severe growth tardation, peculiar facies, pulmonic stenosis, transitory lal tubular acidosis, and vitamin D-resistant rickets. The tients presented in infancy with hepatomegaly and direct perbilirubinemia; liver biopsy at that time revealed cho- asis and paucity of bile ducts. Subsequent serial liver isies have continued to demonstrate cholestasis, but there been no evidence of cirrhosis. Electron microscopy has lied swollen and blunted microvilli of the canalicular rane of the hepatocyte. The patients have had elevated cids in the serum as well as a reversed ratio of tri- to oxy bile acids. Treatment with cholestyramine and pattobarbital has brought about symptomatic relief from esot pruritus and excoriation and has lowered the level of bile acids, although they are still above the normal e. These findings suggest that cholestasis accompanied elevated and reversed bile acid ratio does not univer-ting cause hepatic cirrhosis.

ISSN:0192-0790    

出版商:OVID    

年代:1980

数据来源: OVID

摘要:

The major consequences of cirrhosis stem from development of portal hypertension which leads to bleeding varices, portasystemic encephalopathy, ascites, and hypersplenism. This paper reviews the pathophysiology of portal hypertension with regard to specific causes and the anatomic sites of circulatory derangement. The clinician must understand the mechanisms which lead to clinical complication if current therapy is to be relevant and practical. Controlled clinical trials are really the only way to establish the acceptability of specific therapies.

ISSN:0192-0790    

出版商:OVID    

年代:1980

数据来源: OVID