摘要:

SUMMARY1. In order to determine whether vasodilator prostaglandins (PG) contribute to the acute vascular and endocrine responses to intravenously administered dihydralazine, we examined its effects on systolic and diastolic blood pressure (BP), heart rate (HR), plasma renin activity (PRA) and the plasma catecholamines (CA) noradrenaline (NA), adrenaline (A) and dopamine (DA) as well as on sodium, potassium and creatinine clearance (CNa, CKand CCrrespectively), urinary flow rate, urinary catecholamines (NA, A, DA) and iPGE2and i6‐keto‐PGF1αexcretion rate in six patients (three females, three males) with essential hypertension before and after PG synthesis inhibition by the nonsteroidal, anti‐inflammatory agent diclofenac.2. Diclofenac, which reduced urinary iPGE2and i6‐keto‐PGF1α, excretion by 62% (P= 0.026) and 45% (P= 0.037), respectively, antagonized dihydralazine induced diastolic BP reduction (P= 0.0009), HR increase (P= 0.01), noradrenaline and adrenaline increase in plasma (P= 0.02 andP= 0.05, respectively), increase in urine flow rate (P= 0.03), sodium clearance (P= 0.01) and tended to reduce PRA.3. We conclude that dihydralazine‐mediated changes can be reduced by cyclooxygenase inhibition, most likely on the basis of a reduction of its effect on peripheral resistance, thereby leading to less reflex activation of the sympathetic nervous and renin‐angi

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1985.tb00306.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SUMMARY1. The effects of isocapnic hypoxia on plasma renin activity (PRA) and angiotensin II (AH) concentration were studied in anaesthetized, artificially ventilated dogs. Regression analysis of plasma All concentrationvsPRA, both measured by radio‐immunoassay (RIA), was used as an index of converting enzyme activityin vivo.2. PaO2decreased from 82 to 30 mmHg but regression analysis did not reveal any inhibition of All production within the limits of detection of this method (<20% inhibition).3. We conclude that systemic converting enzyme activity, assessed byin vivomeasurement and correlation of PRA and AII, is not inhibited by severe hypoxi

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1985.tb00307.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SUMMARY1. The selective muscarinic receptor antagonist secoverine was found to have a similar affinity for muscarinic receptors in the guinea‐pig left atrium and ileal longitudinal muscle as well as in the rat urinary bladder and ileu

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1985.tb00308.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY