摘要:

SUMMARY1. The mechanism responsible for ipsilateral renal vasoconstriction resulting from mechanical stimulation of the ureter was examined using the pharmacological antagonists saralasin, SQ20881, indomethacin, atropine and phentolamine.2. A segment of PE tubing was implanted in the left ureter, patency being well maintained. Three to four days later renal blood flow was measured bilaterally and antagonists administered intravenously.3. The mechanism responsible for vasoconstriction could not be attributed to either increased intrarenal noradrenaline or angiotensin, nor to a decreased activity of prostaglandins, kinins or acetylcholine.4. Histological and bacteriological examination also proved negative.5. Thus, additional evidence of an unidentified intrarenal mechanism causing vasoconstriction is presented.

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1978.tb00655.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARY1. Prazosin, clonidine, hydrallazine and diazoxide were administered intravenously, alone or in various combinations, to anaesthetized rats.2. Prazosin and clonidine were equipotent. Their combined hypotensive effects in no instance exceeded the maximum effect attainable with either agent alone. The hypotensive effects of hydrallazine or diazoxide were, in contrast, additive to those of either prazosin or clonidine.3. Pressor responses to clonidine were antagonized by prazosin. Prazosin may prove useful in hypertensive crises provoked by clonidine.

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1978.tb00656.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARY1. The mitotic rate in the crypts of Lieberkiihn of the descending colon and in dimethylhydrazine‐induced adenocarcinomata of the descending colon of rat was measured using a stathmokinetic technique.2. Intraperitoneal injection of a small dose (10 jug/kg) of serotonin resulted in an increase in the tumour cell mitotic rate.3. Blockade of serotonin receptors by 2‐bromolysergic acid diethylamide and depletion of tissue serotonin levels following injection of DL‐6‐fluorotryptophan both result in a decrease in the tumour cell mitotic rate.4. Treatment with serotonin, 2‐bromolysergic acid diethylamide and DL‐6‐fluorotryptophan were all without effect on the colonic crypt cell

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1978.tb00657.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARY1.Gross changes in behaviour and whole brain levels of noradrenaline, dopamine, serotonin and 5‐hydroxyindoleacetic acid were examined in rats for 3 min following intracerebral injections of met5‐enkephalin amide or morphine.2. Both the enkephalin and morphine depressed respiration and induced a cataleptic‐like state, but only the enkephalin produced wet‐shake responses.3. All doses of met5enkephalin amide (150, 200 and 600μg) and morphine (134 and 200 /Kg) increased the brain levels of 5‐hydroxyindoleacetic acid, whereas only the large doses modified the levels of noradrenaline and serotonin.4. The similarity of the effects of these two compounds indicates that morphine may act through an enkephalin‐li

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1978.tb00658.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY