摘要:

SUMMARY1. The interaction of the serotonin precursor L‐tryptophan with the pressor responses of the anaesthetized rat to the intravenous injection of clonidine, adrenaline and angiotensin has been studied.2. Pretreatment of rats with L‐tryptophan (100 mg/kg) depressed the pressor response to clonidine but had no effect on the responses elicited by adrenaline or angiotensin.3. The L‐tryptophan‐induced depression of the clonidine response was prevented by pretreating rats with either Rö 44602, carbidopa, BW 172C58, methys‐ergide or by pithing.4. Intravenous infusions of serotonin depressed the pressor responses to clonidine, adrenaline and angiotensin in both intact anaesthetized and pithed rats.5. It is concluded that the depressant action of L‐tryptophan is dependent on its conversion within the periphery to serotonin. This action is also dependent on or mediated by the sympathetic ne

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1978.tb00672.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARY1. In urethane anaesthetized sham‐operated rats, intravenous administration of Δ1‐THC (1 mg/kg) caused an immediate and prolonged fall in blood pressure, with a concomitant reduction in pulse rate.2. In rats which had been adrenalectomized 24 h previously, Δ1‐THC (1 mg/kg, i.v.) also caused a depressor response, but it was significantly shorter in duration than that observed in sham‐operated animals. The durations of the cardiac slowing effect were similar in both groups of rats.3. Hydrocortisone pretreatment (25 μg/kg>i‐v), given 45 min before Δ1‐THC, restored the duration of the depressor response to Δ1‐THC in adrenalectomized rats, but it did not have any effect on the bradycardia induced by Δ‐THC.4. Hydrocortisone did not produce any significant effect on the hypotensive action of Δ1‐THC in sham‐operated rats, but the cardiac slowing effect was markedly potentiated.5. These results suggest a lack of correlation between the hypotensive and cardiac slowing actions of the drug and that a certein level of adrenal steroids is necessary for the maintenance of the de

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1978.tb00673.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARY1. The purpose of this study was to determine whether hepatic mitochondria of guinea‐pigs with spontaneous diabetes mellitus differ from those of non‐diabetic guinea‐pigs in the oxidation of fatty acids, the activity of β‐hydroxybutyrate dehydrogenase, or respiration‐linked oxidative phosphorylation. During the course of the study, a third group of animals (referred to as the unclassified group) was discovered which, on the basis of the clinical chemistry and histological changes in the pancreas, appeared to be in a pre‐diabetic or post‐diabetic state.2. No differences in the respiratory control ratios were found between any of the three groups. Fatty‐acid oxidation in hepatic mitochondria was greater in both the unclassified and diabetic groups than in the non‐diabetic group. /3‐Hydroxy‐butyrate dehydrogenase activity, however, was increased only in the diabetic group. These findings suggest that increased fatty acid oxidation is probably an intermediate change in the development of or the recovery from diabetes mellitus, whereas the activity of β‐hydroxybutyrate dehydrogenase is affected onl

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1978.tb00674.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARY1. Iopanoic acid and iophenoxic acid were potent inhibitors of compound 48/80‐induced histamine release from rat peritoneal cell suspensions rich in mast cells and caused a parallel dose‐related reduction in ATP content of these cells.2. Lignocaine was less potent and ouabain and probenecid were ineffective in inhibiting histamine release and reducing cellular ATP content.3. Various drugs can inhibit 48/80‐induced histamine release from rat peritoneal cells and this activity may result from depletion of cellular ATP. It is apparent that little structural specificity is required for activity in this cell s

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1978.tb00675.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARY1. The concentration of42K within the jejunal mucosa was measured by intraluminal miniature Geiger‐Müller tubes shielded with platinum foil.2. Isotope concentration measured by tissue assay of jejunal mucosa gave similar results to that obtained by the Geiger‐Müller tubes.3. Isotope measurement by shielded Geiger‐Müller tubes obviates the need for tissue samples and permits repeat measurement in the same animal. This should find physiological application in measuring the mucosal portion of total intestinal blood flow by the indicator fractionation t

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1978.tb00676.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

10th Annual Meeting, 25‐26 November 1976, Adelaide1. Histamine metabolism in aortae of two histamine sensitive species.A. Foldes, M. J. Stacey and I. S. de la Lande2. Localization of histamine in rabbit central ear artery. M. J. Stacey, A. Foldes and I. S. de la Lande3. Effects of antigen and compound 48/80 on the guinea‐pig lung and trachea. K. M. Lulich and J. W. Paterson4. The effect of various drugs on compound 48/80 and osmotic shock‐induced histamine release from rat peritoneal cells. R. O. Day, G. D. Champion and D. N. Wade5. The effects of terbutaline on histamine‐induced dye leakage in guinea‐pig skin. C. G. A. Persson and Stella R. O'Donnell6. Monitoring of drug therapy at Sydney Hospital. G. M. Eckert and C. G. Berbatis7. Event‐oriented monitoring studies of drug therapy in a hospital. G. M. Eckert and C. G. Berbatis8. The use of metoprolol, a selective β‐adrenoceptor blocking agent, for the treatment of hypertension in patients with asthma, or history thereof. A. S. P. Hua and P. Kincaid‐Smith9.Contrasting actions of four peripherally acting antihypertensive drugs. Helen F. Gates, R. M. Graham, and G. S. Stokes10. Oxolinic acid in urinary tract infection.S. Kalowski and P. Kincaid‐Smith11. ED50values in anaesthetic patients for thiopentone, methohexital, propanidid and alfathesin using probit and sequential techniques for data analysis. D. P. Crankshaw and J. Allt‐Graham12. Experimental design simulator (EDS)‐a computer program for the teaching of clinical trial methodology. T. L. Woodings and B. W. Madsen (introduced by J. W. Paterson)13. Deviation from prescribed treatment in a hypertension clinic: effects of an educational programme. J. Shaw, P. Nieman and J. D. England14. An exploratory study on the acute adaptation to ethanol. H. M. Franks, G. A. Starmer and R. K. C. Teo15. Comparative pharmacokinetics of quinine and quinidine in man. A. Lau, G. Graham, D. J. Birkett and S. P. Myers16. Significance of ‘apparent hydralazine’ levels in plasma of man. P. A. Reece, P. E. Stanley and R. Zacest17. The effect of age on the pharmacokinetics of warfarin sodium. Kanda Hotraphinyo, E. J. Triggs, B. Maybloom and A. McLean‐Cross (introduced by J. Thomas)18. Pharmacokinetics of digoxin in thyroid disease. G. M. Shenfield, J. P. Thomson and D. B. Horn (introduced by J. W. Paterson)19. Salivary antipyrine kinetics in health and disease. A. W. Harman, B. G. Priestley, D. B. Frewin and R. K. Penhall20. Pancuronium disposition and response. A. A. Somogyi, E. J. Triggs and C. A. Shanks (introduced by J. Thomas)21. Pharmacokinetics ofd‐tubocurarine chloride in humans. M. I. Ramzan, E. J. Triggs and C. A. Shanks (introduced by J. Thomas)22. The trachea‐heart selectivity of rimiterol in vitro and in vivo in guinea‐pigs. J. C. Wan‐stall and S. R. O'Donnell23. Effects of indoramin on two in vitro smooth muscle preparations. J. Black, C. Hamer, D. Temple and S. D. Anderson24. The effects of monochlorophenethanolamine derivatives on β‐adrenoceptors of guineapigs in vitro. L. G. Letts, D. M. Temple, A. Kilford, Bui Lap, S. N. Quessy and L. Williams25. Development of cholinergic and adrenergic arousal systems in the rat. H. Bartley and G. Singer26. Withdrawn.27. Pre‐ and postjunctional effects of clonidine in isolated guinea‐pig atria. I. Medgett and M. W. McCulloch28. Apparent resistance to the hypotensive effect of clonidine. L. M. H. Wing, J. L. Reid, D. S. Davies, H. J. Dargie and C. T. Dollery (introduced by J. P. Chalmers)29. The use of isolated human arteries to study the action of prazosin and other hypotensive agents. R. Jauernig and R. F. W. Moulds (introduced by J. Shaw)30. Effects of prazosin on plasma cyclic AMP levels in man. J. D. England, R. A. Jauernig, P. W. Trembath and J. Shaw31. Anti‐arrhythmic effect of N‐acetyl procainamide. R. Minchin, K. F. Ilett and J. W. Pater‐son32. The effect of fatty acids on drug binding sites on human serum albumin. S. P. Myers and D. J. Birkett33. The disposition of lignocaine in neonates. J. Thomas, G. W. Mihaly, R. G. Moore and E. J. Triggs34. Perinatal disposition of chlormethiazole used in the management of severe preeclampsia. R. G. Moore, E. Tischler, E. D. Burnard and J. Thomas35. The protein binding of clonazepam and valproate. D. G. Ferry and E. G. McQueen36. Protein binding of tolmetin. M. L. Selley, B. W. Madsen and J. Thomas37. The effect of ethanol on the acquisition of a passive avoidance task. G. Bammer, G. B. Chesher and D. M. Jackson38. Withdrawal reactions in rats following terf‐butanol administration. R. Laverty and Jeanette Wood39. Cyclazocine‐induced physical dependence in the rat. F. J. Laska and M. R. Fennessy40. Intracranial injections of 6‐OHDA: the effect of optimal concentrations on monoamine depletion and consummatory behaviour.G. L. Willis, G. Singer and B. K. Evans41. Schedule‐induced polydipsia or model for the study of drug intake. G. Singer42. The effects of intrahypothalamic injections of 6‐OHDA on schedule induced polydipsia. A. McQueen and G. Singer43. Caffeine‐phenacetin interaction in the rat: effects on absorption, metabolism and locomotor activity. C. Collins, P. T. Richards and G. A. Starmer44. Subsensitivity to pilocarpine following a single administration of the irreversible anticholinesterase DFP.D. H. Overstreet, S. C. Helps, A. M. Prescott and G. D. Schiller45. Is malignant hyperpyrexia muscle denervated?R. F. W. Moulds (introduced by J. Shaw)46. Drug treatment for malignant hyperpyrexia. K. L. Austin and M. A. Denborough (introduced by J. Chalmers)47. Identification of some constituents of the venom of the Sydney funnel‐web spider, Atrax robustus, using gas chromatography/mass spectrometry.P. H. Duffield, A. M. Duf‐field, P. R. Carroll and D. Morgans48. Adrenergic activity of components of the venom of the Sydney funnel‐web spider, Atrax robustus.P. R. Carroll, D. Morgans, A. M. Duffield and P. H. Duffield49. Toxicity due to drug metabolism: direct evidence. M. J. Cousins (introduced by L. B.50. The toxicity of halogenated volatile anaesthetics in isolated rat hepatocytes. N. H.Stacey, B. G. Priestly and R. C. Hall51. The effects of hepatoprotective treatments on CCI4toxicity in isolated rat hepatocyte suspensions.N. H. Stacey and B. G. Priestly52. Adverse reactions to drugs: a twelve‐month hospital survey. K. A. McMahon, D. B. Frewin, E. G. Easterbrook, E. A. Hender, T. I. Lee and P. K. Penhall53. Pharmacokinetics of14C‐haloperidol in man.K. F. Ilett, A. E. Mackie, L. B. Jellett, B. W. Madsen, K. Somers and I. E. Hughes54. Comparison of direct and indirect pharmacokinetic methods for assessing hepatic clearance of drugs.L. E. Mather and G. T. Tucker (introduced by J. Chalmers)55. Disopyramide pharmacokinetics and bioavailability. D. K. Dubetz, N. N. Brown, W. D. Hooper, M. J. Eadie and J. H. Tyrer56. The continuing saga of in vivo‐in vitro bioavailability evaluations‐a study with sulphi‐soxazole. G. W. A. Slywka, P. L. Whyatt and M. C. Meyer57. The pharmacokinetics of Iabetalol and its effects on blood pressure and plasma noradrenaline and plasma renin in hypertension. M. J. Brignell, L. J. Graf and W. J. Louis58. Comparison of serum drug concentrations during a clinical trial of benorylate, acetyl salicylic acid and paracetamol with acetyl salicylic acid. P. J. Keary, R. Laurent and D.G. Ferry59. Pharmacokinetics of carprofen in man. J. E. Ray, J. O. Bostrom and D. N. Wade60. The effects of isoprenaline inhalation on arteriovenous differences in plasma cyclic AMP levels in dogs. P. W. Trembath and J. Shaw61. The demonstration of an increase in dopamine receptor responsiveness after long term administration of dexamphetamine to mice. R. Bailey and D. M. Jackson62. The uptake and release of octopamine by mammalian brain. G. Sudlow, D. F. H. Dougan and D. N. Wade63. Uptake and removal of noradrenaline and isoprenaline by the hypothalamus of the possum.J. Minson and R. C. Hall64. Interaction of caffeine with intracerebral dexamphetamine on locomotor activity of ratsP. Braes and D. M. Jackson65. Cholinergic hyposensitivity in mice after withdrawal from long‐term haloperidol trenapse.O. P. Hamill, D. J. Adams and P. W. Gage (introduced by P. R. Carroll)67. Withdrawn by authors.68. Vasodilator response to guanethidine mediated by endogenous histamine. J. A. Angus, A. Bobik and P. I. Korner69. Effects of intraventricular injections of histamine on arterial blood pressure and heart rate in conscious rabbits. E. Malta, P. R. C. Howe, J. C. Lloyd and J. P. Chalmers70. Blockade by phentolamine of the potentiating action of tetraethylammonium in the rabbit ear artery. P. R. Carroll and D. Morgans71. Effects of prostaglandins on vasoconstriction in the rat mesentery. P. L. McLennan and I. M. Coupar (introduced by A. L. A. Boura)72. Differential effects of digoxin at comparable concentrations in tissues of foetal and adult sheep. P. J. Ravenscroft, W. Berman, L. B. Sheiner, M. A. Heymann, K. L. Melmon and A. M. Rudolph73. Coronary vasodilatation elicited by electrical stimulation of the canine hypothalamus. R. Padanyi, W. J. Lang and C. Bell74. Responses of sheep coronary arteries to transmural stimulation. E. J. Cornish, R. C. Miller and F. G. Brine75. Mechanism of inhibition of tolbutamide metabolism by phenylbutazone and oxyphen‐butazone. S. M. Pond, D. J. Birkett and D. N. Wade76. Time course of cadmium‐induced inhibition of hepatic microsomal enzymes in the rat.P. G. Peters and B. G. Priestly77. Comparative study of14C‐phenanthrene in hepatic microsomal systems.S. Chaturapit, G. M. Holder and D. M. Jerina (introduced by Professor J. Thomas)78. A14C‐phenacetin breath test in the assessment of hepatic drug clearance. P. V. Desmond, K. J. Breen, R. W. Bury, I. Calder and M. L. Mashford79. The metabolism of styrene oxide in the isolated perfused rat liver. A. J. Ryan and J. R. Bend (introduced by J. Thomas)80. The absorption of benorylate in an in vitro everted rat small intestine model. P. Paull, D. N. Wade and G. G. Graham81. Biliary excretion of rifampicin in the conscious pig. N. G. Kingsley, S. Jeffries, M. Rose and J. M. Ham82. α‐Adrenoreceptor blockade by oxprenolol. M. Law, M. J. Rand and D. F. Story83. β‐Adrenoreceptors in hearts and kidneys of hypertensive rats. E. A. Woodcock, C. I. Johnston, N. M. A. Walter and J. W. Funder84. Haemodynamic effects of oxprenolol during anaesthesia: dose‐response studies. J.G. Roberts and P. Foex (introduced by L. B. Geffen)85. Catecholamines based on the phenoxypropanolamine nucleus: activity in the anaesthetized cat.G. S. Keh and C. Raper86. The use of fluorescence histochemistry to compare isoprenaline accumulation in trachea and atria of guinea‐pig and cat. E. N. Anning, L. J. Bryan and S. R. O'Donnell87. Cardiovascular aspects of the action of substanceP. R. W. Bury and M. L. Mashford88. Patterns of changes in plasma levels of valproate and phenytoin in patients on multiple anticonvulsant therapy. F. J. E. Vajda and P. M. Morris89. Factors influencing plasma phenobarbitone levels in epileptic patients. C. M. Lander, M. J. Eadie.W. D. Hooper and J. H. Tyrer90. Phenytoin tracer half‐lives in epileptic and non‐epileptic subjects. A. Richens (introduced by M. J. Eadie)91. Pharmacokinetics of ethosuximide in man. L. McKauge, G. A. Smith, J. H. Tyrer and M. J. Eadie92. Pharmacokinetics and interactions of valproate in man.G.A.Smith, L. McKauge, J. H. Tyrer and M. J. Eadie93. The calculation of repititive dose accumulation for non‐linear pharmacokinetic systems.W. J. O'Reilly94. The effect of calcium on the interaction between acetylcholine and noradrenergic transmission in the rabbit ear artery. W. Hope, M. W. McCulloch, M. J. Rand and D. F. Story95. Dopamine‐β‐hydroxylase content and activity in purified noradrenergic vesicles. R. L. Klein, D. F. Kirksey, R. A. Rush and M. Goldstein (introduced by L. B. Geffen)96. Metabolism of noradrenaline in the rabbit ear artery.I. S. de la Lande, R. J. Head and D. A. S. Parker97. The effect of ovarian steroids on the metabolism of noradrenaline in the rabbit uterus. I. S. de la Lande and J. A. Kennedy98. Pharmacokinetics of pranolium chloride in normal volunteers. M. C. Kennedy, J. C. Middleton and D. N. Wade99. Pharmocokinetic studies of prindolol in man. A. Bobik, G. Jennings and P. I. Korner100. Clinical effects of prindolol in man and their relationship to plasma concentration.G. L. Jennings, A. Bobik, E. Fagan and P. I. Korner101. Pharmacokinetics of metoprolol in hypertensive patients. A. J. Wood, H. J. Waal‐Manning and P. Bolli102. Characteristics of in vitro accumulation of14C‐haIoperidol by rat lung. L. D. Brett, K. F. Ilett and J. W. Paterson103. A morphine‐sensitive dopaminergic interneurone in the Myenteric plexus of the guinea‐pig ileum. R. L. Heimans (introduced by M. J. Rand)104. Histochemical and pharmacological studies of aminergic neurones in the guinea‐pig small intestine. M. Costa and J. B. Furness105. Levodopa metabolites and side effects of levodopa therapy. M. W. Nott106. Dopaminergic nerves in vascular control. W. J. Lang and C. Bell107. Sites of drug action on nigrostriatal dopaminergic neurones. L. B. Geffen108. Modulation of transmitter release from sympathetic nerves by dopamine. D. F. Story, W. Hope, M. W. McCulloch and M. J. Rand109. Dopamine, the mesolimbic system and behaviour. D. M. Jackson, P. U. Braes, R. Dunstan and J. Engel110. Dopamine and hypothalamic‐pituitary neuroendocrine control. G. Smythe and L. Lazarus111. The use of methyldopa in the treatment of Huntinton's chorea. E. L. Conway, B. Jarrott, J. McNeil and W. J. Louis112. The biosynthesis of dopamine and noradrenaline. W. J. Louis, A. Culv

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1978.tb00677.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY