摘要:

SUMMARY1. The effects of mexiletine and quinidine were compared on transmembrane potentials in guinea‐pig papillary muscles, using conventional microelectrode techniques.2. Mexiletine (23–1 μ mol/1) decreased the maximum rate of rise of the action potential (V̇max) and increased the ratio of the effective refractory period to the action potential duration at 90% repolarization level (ERP/APD90); these effects were prominent with elevation of the external potassium concentration ([K]o) from 2–7 to 5–4, 81 and 100mmol/1.3. The percentage decrease in V̇max induced by 5 and 10 μmol/1 of quinidine was approximately constant in 2–7, 5–4 and 100 mmol/1 [K]osolutions.4. The decrease in V̇max produced by mexiletine was progressively increased as the driving rate was raised from 0–25 to 5H z. This rate‐dependent change was pronounced when the concentration was raised from 23–1 to 46–2 and 92–4 /μmol/1.5. Mexiletine in concentrations of 23–1 and 92–4 μ miol/1 delayed the recovery of V̇max in a premature action potential to the level of V̇max in the conditioning action potentials at the driving rate of 0–25 Hz.6. It appears that mexiletine exerts its anti‐arrhythmic action by a selective depressant effect on depolarized cells (high [K]o) and cells with high frequency disc

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1980.tb00116.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARY1. Hepatic sulphobromophthalein (BSP) transport was studied in guinea‐pigs pretreated intraperitoneally with 0 7 ml of diethyl maleate to depress hepatic glutathione levels.2. Diethyl maleate depressed the hepatic transport of infused conjugated BSP from hepatocytes into bile without influencing hepatic uptake.3. Unconjugated BSP transport was also depressed markedly as a result of (a) a reduction in the intrahepatic conjugation of BSP with glutathione and (b) suppression of conjugated BSP excretio

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1980.tb00117.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARY(1) Male castrated rats (testosterone‐free) inoculated intraperitoneally withStaph, aureusshowed severe damage in their internal organs as determined by pathological examination of the killed animals.(2) Penicillin‐G, oxytetracycline and chloramphenicol treatment 24 h after injection markedly decreased the extent of damage.(3) Pretreatment of castrated rats with testosterone propionate for 3 successive days before infection had a protective influence on the internal organs.(4) Testosterone‐injected rats when treated with different antibiotics, showed a clear synergistic action with penicillin‐G and oxytetracycline but not chloramp

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1980.tb00118.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARY1. Auditory and visual evoked potentials produced by five intensities of tones and light flashes were recorded in twelve young men who were habitual smokers.2. The subjects attended the laboratory on four occasions. Two recordings were made on each of the last three of these visits. They were made (i) before and after smoking, (ii) without smoking, (iii) before and after smoking after 12 h abstinence from smoking.3. Smoking was associated with increases in the amplitudes of the components V‐VI, VI‐VII in the visual system and a decrease in the amplitude of N2P2in the auditory system. Abstinence from smoking produced effects in the opposite direction.4. These findings are consistent with the possibility that smoking has different and perhaps opposite effects on the visual and auditory system.5. The findings may be helpful in re‐evaluating some of the apparently conflicting reports on the effects of smoking on perceptual proc

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1980.tb00119.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARY1. The cardiovascular effects of sodium glutamate were investigated in anaesthetized dogs with bolus injections, intravenous infusions and rabbit isolated papillary muscles.2. The intravenous bolus injections of sodium glutamate resulted in slight, transient decreases in contractile force at doses of 58 and 117 mg/kg, which were followed by brief increases in blood pressure.3. Sodium glutamate had no effect on contractile responses of isolated papillary muscles at any of the concentrations used.4. Infusions of glutamate produced no change in blood pressure, an increase in cardiac output, and a decrease in heart rate, total peripheral resistance and femoral vascular resistance.5. The infusion of sodium glutamate into animals with no renal function resulted in an increased plasma osmolality and a decreased haematocrit.6. The results from this study show that sodium glutamate had minimal cardiovascular effects. The results from the infusion data suggest that glutamate increases intravascular volume by an osmotic effect.

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1980.tb00120.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARY1. The radioactive microsphere method was used to measure the distribution of cardiac output, regional flows and resistances in conscious normotensive and hypertensive rabbits implanted with an electromagnetic flow probe on the ascending aorta or pulmonary artery. Hypertension was induced by wrapping one kidney with cellophane and removing the other, and studies were performed about 5 weeks later.2. Heart rate, stroke volume, cardiac output and total renal mass were reduced in the hypertensive animals, while the weight of, and the cardiac output distribution to left ventricle and the remaining kidney were increased.3. In renal hypertensive rabbits, the weight normalized regional blood flow was diminished in a number of tissues, including the kidney, and, except for some organs in the splanchnic area (stomach, small intestine, mesentery and pancreas) and the fat, there was a rather uniform increase in tissue vascular resistance.

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1980.tb00121.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARY1. The administration of an initial dose of 50 μg/kg of 48/80 produced a sharp fall in the blood pressure of normotensive rats but produced little change in blood pressure in spontaneously hypertensive rats.2. The administration of an additional 50 μg/kg and 100 μg/kg of 48/80 in normotensive and spontaneously hypertensive rats resulted in equivalent decreases in pressure in both groups.3. Both groups had equivalent decreases in blood pressure in response to methylhistamine.4. Spontaneously hypertensive rats appear to have a reduced ability to release histamine in response to 48/80 due to either an increased threshold for 48/80 or a diminished histamine storage po

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1980.tb00122.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

1.The development of the prejunctional receptor hypothesis. M.W. McCulloch, M.J. Rand and D. F. Story2.Adrenoceptor‐ and cholinoceptor‐mediated modulation of transmitter release at the somatic neuromuscular junction. C. Raper3.Conditions of operation of positive and negative feedback regulation of transmitter noradrenaline release. D.F. Story and I.C. Medgett4.Failure of a receptor blockade–a pre‐ and post‐synaptic phenomenon. G.D.S. Hirst and T.O. Neild5.Are radioligand assays useful for identification and characterization of prejunctional receptors?R.J. Summers and B. Jarrott6.Prejunctional modulation of postganglionic cholinergic nerves. F. Mitchelson7.Opiate receptor modulation of transmitter release. J.E. Olley* and A.L.A. Boura8.Prejunctional receptors of human vascular sympathetic nerves. R.F. W. Moulds9.Clinical implications of autonomic prejunctional receptors. J. Shaw10.Correlations between the antihypertensive and haemodynamic effects of oxprenolol. R. Zacest, M.A. Robinson and L.L. Wilson11.Comparison of long acting and short acting diuretics in mild essential hypertension. L.M.H. Wing, M.J. West, J.R. Graham and J.P. Chalmers12.Effects on heart rate and blood pressure during graded exercise of beta adrenoceptor blocking drugs with and without intrinsic sympathomimetic activity (ISA) or ‘cardio‐selectivity’. G. Jennings, A. Bobik, P. Ashley, R. Newman, S. Ellet and P. Korner13.Study of the effects of acute dosing with ac‐methyl dopa on reflex autonomic tachycardia. A.J. McLean, G. Jennings and P.I. Korner14.A study of in vitro vasoactivity of C.S.I, and the clinical state of patients who have had a subarachnoid haemorrhage. R.F.W. Moulds, C. Mylonas, R. Medcalfand D. Brownbill15.Retrospective survey of digoxin usage. C. Corallo and K. Raymond16.Dihydroergotamine kinetics in patients with orthostatic hypotension. A. Bobik, H. Skews, G. Jennings, M. Esler and P.I. Korner17.Effect of probenecid on clofibrate disposition in man. J.R. Veenendaal. P.M. Brook and P.J. Meffin18.Pharmacokinetics in human malnutrition. N. Buchanan19.Impairment of an hepatic protective mechanism in man by food ingestion. A.J. McLean, C. Isbister, A. Bobik and F.J. Dudley20.Carbamazepine monotherapy in epileptic patients. G.W. Mihaly and F.J.E. Vajda21.Simultaneous determination of aspirin, salicyclic acid, salicyluric acid and gentisic acid in plasma by HPLC. R.H. Rumble and M.S. Roberts22.Association between angiotensin conversion and prostacyclin release in isolated mesenteric vasculature of rats. G.J. Dusting and E.M. Mullins23.Prostacyclin inhibits contractions of the rat isolated descending colon in response to field stimulation. I.R.N. Relf and A.L.A. Boura24.Bradykinin induced spasm of the human umbilical vein is mediated via activation of phospholipase‐A and potentiated by cooling. A.L.A. Boura, A.S.C. Sandford, R.J. McRae and W.A.W. Walters25.L‐Tryptophan‐induced depression of α‐adrenoceptor mediated vascular responses in the rat. P.L. Nolan and J.W. Caygill26.Evidence against a physiological role of presynaptic alpha adrenoceptors in heart. J.A. Angus and P.I. Korner27.The effect of DOCA hypertension on responses of the rat tail artery to potassium chloride and electrical stimulation. M.G. Venning and I.S. de la Lande28.A possible histaminergic component of the clonidine withdrawal syndrome in the rat. S.J. Lewis, M.R. Fennessy and D.A. Taylor29.Clonidine withdrawal syndrome and endogenous biogenic amines. D.A. Taylor, S.J. Lewis and M.R. Fennessy30.The effects of sub‐acute L‐DOPA treatment of mice on L‐DOPA‐induced hyperactivity. O. Jenkins, R. Bailey, E. Crisp and D.M. Jackson31.Chronic L‐DOPA pretreatment of mice: production of dopamine receptor supersensitivity?R. Bailey, E. Crisp, D.M. Jackson and O. Jenkins32.Accumulation of α‐methylated phenolamines in rat brain after chronic administration of a‐methyltyrosine. P.H. Duffield, D.F.H. Dougan, D.N. Wade and A.M. Duffield33.Effect of unilateral lesions on octopamine and tyramine concentrations in rat striatum. D.F.H. Dougan, P.H. Duffield, D.N. Wade, A.M. Duffield and G. Paxinos34.Effect of surgical denervation on α1and α2‐adrenoceptors in rat cerebral cortex. M.J. Morris, J.L. Elghozi, J.P. Dausse and P. Meyer35.Localization of |3H|clonidine binding sites in membranes prepared from guinea pig renal cortex. G. McPherson and R.J. Summers36.Characterization of (3H)cIonidine binding sites in membranes prepared from guinea pig spleen. R.J. Summers and G. McPherson37.Alpha‐adrenergic receptors modulate agonist affinity for beta‐receptors in rat kidney membranes. E.A. Woodcock and C.A. Olsson38.Pentobarbitone enhancement of GABA binding. M. Willow and G.A.R. Johnston39.Stress induced changes in Leucine‐enkephalin binding and plasma corticosterone in mice. M.J. Christie, P. Trisdikoon, J. Eross and G.B. Chesher40.Duration of the analgesic effects of some opiate‐like peptides following intracerebroven‐tricular (i.c.v.) administration in the rat. M.J. Quinn and M.R. Fennessy41.Relationship between δ9‐tetrahydrocannabinol (δ9‐THC) withdrawal behaviour and brain regional levels of histamine (HA) in the rat. A.J.M. Verberne, D.A. Taylor, S.J. Lewis and M.R. Fennessy42.Long‐term effects of a single dose of haloperidol or thioridazine on schedule induced drinking. G. Singer44.Effect of o‐methylflavinantine on contractions of the guinea‐pig longitudinal muscle induced by co‐axial electrical stimulation. R. Ansa‐Asamoah and G.A. Starmer45.Do endogenous purine nucleosides modulate the release of acetylcholine at the mammalian neuromuscular junction? I. Spence46.Effect of adrenaline on transmitter noradrenaline release. H. Majewski, M.W. McCulIoch, M.J. Rand and D.F. Story47.Effects of tetrodotoxin on release of noradrenaline by nicotine in rabbit atria. C. Sarantos‐Laska, M.W. McCulloch, D.F. Story and M.J. Rand48.The effect of ventilatory gas composition on arachidonic acid metabolism in isolated perfused guinea‐pig lungs. V. Iwanov, J. Staszewska‐Barczak and G.J. Dusting49.An isolated perfused adrenal preparation for studying adrenal catecholamine secretion. A.R. Collett and D.F. Story50.Inhibition of nerve‐mediated contractions in isolated guinea‐pig ileum by 1‐methyliso‐guanosine, a novel purine from a sponge. D. Jamieson and P. Davis53.β‐Adrenoceptors and catecholamine‐induced responses of human and porcine peripheral lung strip: Effects of uptake inhibitors. R.G. Goldie and G.M. Ellis54.Uptake and release of N‐methyl‐D‐aspartate by rat brain slices. J.H. Skerritt and G.A.R. Johnston62.Receptor binding assay for detection of endogenous opioids. P.M. Lewis and J.E. Olley63.Prospective drug utilization study of antibiotics based on blood level assays. A. Saunders and K. Raymond57.The pharmacokinetics of chlorbutol. C. Tung, G.G. Graham, D.N. Wade and K.M. Williams58.Effect of desmethylimipramine on the anorectic activity and tissue distribution of chlorphentermine in rats. R.F. Minchin, K.F. Ilett and B.W. Madsen59.Effects of a new monoamine oxidase‐A selective inhibitor (MD780515) on amine metabolism in the small intestine. K.F. Ilett, C.F. George and D.S. Davies60.Hepatic elimination of sodium valproate(SV). F.J.E. Vajda, A.W. Marshall, G.W. Mihaly, R.A. Smallwood, J. Baldas and J. Phillips61.A sensitive method for measurement of catecholamines and their metabolites in extracts of small brain areas. P.R. Rowe, R.J. Summers and P.M. Beart62.Receptor binding assay for detection of endogenous opioids. P.M. Lewis and J.E. Olley63.Prospective drug utilization study of antibiotics based on blood level assays. A. Saunders and K. Raymond64.Gastric absorption of valproate in rats. N.D. Yeomans, F.J.E. Vajda and J. Baldas65.Elimination kinetics of labetalol in severe renal failure. D.G. Ferry, A.J. Wood and R.R. Bailey66.High pressure liquid chromatographic analysis of ranitidine.G.W. Mihaly, O.H. Drummer, A.W. Marshall, W.J. Louis and R.A. Smallwood67.Model independent pharmacokinetics of slow intravenous infusions.K. Raymond and D.J. Morgan68.Fate of oral hydrallazine in slow and fast acetylators.I. Cozamanis, PJ.D. Horowitz, P.M. Morris, A.J. Goble and W.J. Louis70.The pharmacokinetics of midazolam in man.M.T. Smith, M.J. Eadie, T. O'Rourke‐Brophy and T.C. Smith71.The perinatal disposition of thiopentone.L. Wolf, D.J. Morgan, G.L. Blackman and J.D. Paull72.Minor metabolites of 5‐fluorocytosine in man.K.M. Williams, A.M. Duffield, R.K. Christopher and P.J. Finlayson73.Steady‐state bioavailability of a slow release theophylline formulation in children with acute asthma.D.J. Birkett, K. Coulthard, J.O. Miners, J.J. Grygiel, N. Grgurinovich and D. Lines74.Protein binding of non‐steroidal anti‐inflammatory drugs in rheumatoid arthritis. S.Wanwimolruk, D.J. Birkett and P. Brooks75.The measurement of mouth‐caecal transit time using salicylazosulphapyridine.E.J. Begg, M. Kennedy, P.M. Chinwah and D.N. Wade76.Mechanisms of acute hypertension and bradycardia following intracisternal 6‐hydroxy‐dopamine in conscious rabbits.G.A. Head and P.I. Koraer77.Effects of dopamine on renal function and kallifrein excretion in the isolated perfused rat kidney.B.P. McGrath, P.G. Matthews, L. Leversha, P. Jablonski and B. Howden78.A comparison of the effects of Endrallazine and Hydralazine on isolated human arteries and veins.S. Lipe, R. Medcalf, V. Iwanov and R.F.W. Moulds79.Studies on amphetamine‐induced circling in rats with substantia nigra lesions.J.S. McKenzie, S. Hannigan and A. Churchyard80.Further studies on the peripheral antinociceptive action of morphine.G.A. Bentley, S.H. Newton and Jennifer Starr81.Chronic haloperidol treatment of rats and a‐adrenergic receptor sensitivity.A. Per ring‐ton, R. Einstein and D.M. Jackson82.Anticonvulsant activity of propranolol.Jenny Papanicolaou, F.J.E. Vajda and W.L Louis83.Glycine and dopamine in the ventral tegmental area of the rat. A.L.Gundlach,D.McDonald and P.M. Beart84.Effects of beta‐adrenoceptor antagonists on the haemoglobin‐oxygen (Hb‐O) dissociation curve in vitro and in vitro.P.W. Trembath, E.A. Taylor, M. Roberts, and J. Amess85.Clonidine analogues and hypothermia in mice.P.L. McLennar86.Myolytic effects of Australian snake venoms in monkeys(Macaca fascicularis). S.K. Sutherland and D.G. Campbell87.Prevention of sulphur‐induced bronchoconstriction by disodium cromoglycate (DSCG)

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1980.tb00123.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1980.tb00124.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Cardiovascular Drugs. Volume 4, Antihypertensive Drugs Today.Ed. by R.N. Brogden.Cross‐Bridge Mechanism in Muscle Contraction. Ed. by Haruo Sugi and Gerald H. Pollack.Glucagon in Gastroenterology. Edited by J. Picaz

ISSN:0305-1870    

DOI:10.1111/j.1440-1681.1980.tb00125.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY