ISSN:1076-2752    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:1076-2752    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:1076-2752    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:1076-2752    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:1076-2752    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:1076-2752    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

The objective of this study was to determine whether total serum IgE levels are elevated in workers with trimellitic anhydride-induced asthma as compared with anhydride-exposed workers without an occupational immunologic syndrome. Sera from 12 highly exposed workers with trimellitic anhydride-induced asthma, and from 31 similarly exposed workers without occupational immunologic disease, were assayed for total immunoglobulin E (IgE) levels by Total IgE II FAST™ analysis. The mean total IgE levels were 176.74 ng/mL and 34.55 ng/mL respectively. The difference between the two groups was statistically significant, but considerable overlap of IgE levels between groups was seen. In conclusion, although mean total IgE levels are significantly different between TMA-exposed workers with or without occupational asthma, the significant amount of overlap and poor sensitivity of the test preclude the use of this assay in the individual evaluation of these workers.

ISSN:1076-2752    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Shift work has been associated with various unfavorable pregnancy outcomes (ie, pregnancy loss, spontaneous abortion, low birth weight, etc). The suggested underlying mechanism is the interference of shift work with the circadian regulation of human metabolism and, in particular, with the temporal pattern of endocrine function. To analyze the effect of shift work on fecundity, the Time of Unprotected Intercourses (TUI) has been measured in couples recruited in the European Studies on Infertility and Subfecundity, which were undertaken in seven European countries. A low (odds ratio < 2.0) but consistent excess risk of subfecundity (TUI ≥ 9.4 months) has been observed both in a representative sample of the general population of women in reproductive age and in a sample of pregnant women or women who had just given birth. The excess risk was also consistently evident both in the subsample of the first pregnancies and in the subsample of the most recent pregnancies. Only the exposure of women to shift work seemed to affect a couple's fecundity; men working shift work did not modify the fecundity pattern of their own couples. No specific job title among shift workers concentrated the risk of subfecundity. No association of menstrual disorders with shift work was identified. Even though residual confounding could partly account for the results and the fact that a plausible biological explanation of the claimed effect is still lacking, data from this study are in favor of an association between shift work and prolonged waiting time to pregnancy.

ISSN:1076-2752    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Dis/ability assessment is a complex process that requires consideration of both work demands and clinical conditions. It is commonly practiced in two very distinct fashions. First, poorly specified processes are used to reach decisions about highly specific situations; second, broad generalizations are often applied, which may be poorly applicable to specific situations. A new approach allows the integration of these two methods. The "atomic" approach has two phases: "disaggregation" into the smallest possible meaningful knowledge units (atoms) and then "reintegration" (reassembly). Individual information units may be applicable to a wide variety of different situations, providing an efficient system. The atomic approach includes two tracks that merge to produce the dis/ability assessment: Clinical track (diagnosis → confirmation test; diagnosis → impact assessment test → test result → physiologic/anatomic limitation; and the job demand track (job → task → sub task → functional work demand index → empiric data). The approach described offers advantages of rationality, empiric and face validity, and efficiency. The logic is fully explicable, and most information units (atoms) can be used in many ways to cover new situations. It is applicable to both individual case situations and to large-scale system development.

ISSN:1076-2752    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

The Occupational Safety and Health Administration (OSHA) has proposed a reduction in the permissible exposure limit for methylene chloride from 500 parts per million (ppm) to 25 ppm (8-hour time-weighted average [TWA]). Part of the rationale for lowering the standard is a concern over potentially adverse cardiac effects secondary to elevated carboxyhemoglobin (COHb) levels as a byproduct of methylene chloride metabolism. Employees exposed to methylene chloride as part of a triacetate fiber production process had average values of COHb ranging between 1.77% and 4.00% in the nonsmoking group and between 4.95% and 6.35% in a smoking group, with individually measured methylene chloride exposures averaging up to 99 ppm (8-hour TWA). A dose-response effect was seen only in the nonsmoking group. Additional daily cumulative exposure to methylene chloride did not produce increased levels of COHb. Data from this study support the fact that the COHb levels resulting from exposure to methylene chloride at or below the current American College of Government Industrial Hygienists limit of 50 ppm (8-hour TWA) are of a sufficiently low level that they are unlikely to produce adverse cardiac effects in humans.

ISSN:1076-2752    

出版商:OVID    

年代:1996

数据来源: OVID