摘要:

Mouse embryo fibroblast cell cultures were treated with chemicals that are major components of sidestream (passive) cigarette smoke. These components were 4-aminobiphenyl and aniline-HCl. The cultures produced severely reduced levels of alpha/beta interferon after challenge with polyriboinosinic-polyribocytidylic acid when compared to control cultures. Treatment of additional cell cultures with 2-methylquinoline, an intermediate-level component of sidestream tobacco smoke, or hydrazine-sulfate, a minor component of sidestream tobacco smoke but a major component of mainstream (active) tobacco smoke, also resulted in inhibition of interferon induction with polyriboinosinic acid-polyribocytidylic acid. Therefore, treatment of the cell cultures with chemicals that are carcinogenic was equally effective in inhibiting alpha/beta interferon induction without regard to the sidestream or mainstream smoke origin of the chemical.

ISSN:0030-2414    

DOI:10.1159/000225691

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Inhibitors of polyamine synthesis were tested for therapeutic effectiveness on transplantable prostate cancer. Inhibition of either ornithine decarboxylase or S-adenosyl-L-methionine decarboxylase (AMDC) by α-difluormethylornithine (DFMO) or methylglyoxal-bis[guanylhydrazone] (MGBG), respectively, was associated with significant antitumor effect. The combination of DFMO with MGBG was not only more effective but no more toxic than MGBG alone. Combination of MGBG with 9-B-D-arabinofuranosyladenine, an indirect effector of SAMDC, failed to increase therapeutic effectiveness of MGBG

ISSN:0030-2414    

DOI:10.1159/000225692

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The effects of renal infarct on the immunological response of mice with renal cell carcinoma were studied by a series of adoptive transfer experiments. It appears that in this animal model renal infarct does not favorably affect the immune system by preventing the development of metastasis or increasing the neutralizing ability of sensitized lymphocytes in the adoptive transfer experiments.

ISSN:0030-2414    

DOI:10.1159/000225693

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Centrifugal elutriation has been adapted for use in obtaining highly enriched populations of leukemic myeloblasts and normal appearing lymphocytes from RFM/UN mice with myeloid leukemia. The myeloblasts were functionally intact as evidenced by their high cloning efficiency in vitro and malignant potential in vivo. The lymphocyte-enriched subpopulation had a low thymidine labeling index, and cloning efficiency in vitro, and was only marginally malignant in vivo indicating minimal contamination by leukemic myeloblasts. In preterminal leukemic mice the proportion of cycling leukemic cells remained high with a labeling index of 30–50

ISSN:0030-2414    

DOI:10.1159/000225694

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Nicotinamide and isonicotinamide were administered separately as 1% solutions continuously in drinking water to 6-week-old randomly bred Swiss mice for their life span. Consumption of these chemicals caused no apparent carcinogenic action under the present experimental conditions.

ISSN:0030-2414    

DOI:10.1159/000225695

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000225696

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000225697

出版商:S. Karger AG    

年代:1983

数据来源: Karger