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11. |
The Effect of Sodium Perchlorate and Ionizing Irradiation on the Thyroid Parenchymal and Pituitary Thyrotropic Cells |
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Oncology,
Volume 48,
Issue 4,
1991,
Page 317-320
Zdenka Pajer,
Miroslav Kališnik,
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摘要:
In a 46-week-experiment on 72 female mice the influence of peroral 1.2% sodium perchlorate application, total ionizing irradiation with 8 Gy on 5 consecutive days and their interaction on the pituitary-thyroid axis was studied by histological and stereological methods. It was observed that perchlorate alone caused long-term and strong hypothyroidism with hypertrophic and hyperplastic thyroid epithelial cells as well as pituitary thyrotropic cells. When only irradiation was used, no uniform changes in the structure and function of these cells could be detected. The interaction of perchlorate and irradiation showed similar effects as thyrostatics alone, with some exceptions; paradoxically, minor hyperplasia of thyrotropic as well as of parafollicular cells was observed. A high percentage of the follicular cell carcinoma was found after perchlorate application and after its combination with irradiation. No medullary carcinoma was found.
ISSN:0030-2414
DOI:10.1159/000226950
出版商:S. Karger AG
年代:1991
数据来源: Karger
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12. |
Serum Sialyl-Tn Antigen Levels in Patients with Digestive Cancers |
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Oncology,
Volume 48,
Issue 4,
1991,
Page 321-326
Yoshiharu Motoo,
Hiroyasu Kawakami,
Hiroyuki Watanabe,
Yoshitake Satomura,
Hideki Ohta,
Takashi Okai,
Hiroshi Makino,
Daishu Toya,
Norio Sawabu,
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摘要:
Serum levels of sialyl-Tn antigen (STN) were measured using a one-step radioimmunoassay kit in 257 patients with digestive cancers, 121 patients with benign digestive diseases, and in 64 healthy controls. With 45 U/ml regarded as the cutoff value, the positive rates of serum STN in digestive cancers were as follows: pancreas 40.0%, stomach 28.1, colon and rectum 27.8, biliary tract 25.0, liver 7.1, and esophagus 0%. In benign digestive diseases, the positive rate of STN was low (4.1%). In gastric and colorectal cancers, simultaneous measurements of STN and carcinoembryonic antigen (CEA) revealed that the positive rates of STN, CEA, and STN and/or CEA were 28, 42, and 55%, respectively. There was no significant correlation between STN and CEA in these cancers. STN may be a useful serum marker for digestive cancers, especially gastric and colorectal cancers.
ISSN:0030-2414
DOI:10.1159/000226951
出版商:S. Karger AG
年代:1991
数据来源: Karger
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13. |
Anthracycline Cardiotoxicity: In vivo and in vitro Effects on Biochemical Parameters and Heart Ultrastructure of the Rat |
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Oncology,
Volume 48,
Issue 4,
1991,
Page 327-333
Grazia Cini Neri,
Bruno Neri,
Manuela Bandinelli,
Mario Del Tacca,
Romano Danesi,
Rossella Riccardi,
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摘要:
The premise of this study is that mitochondrial lesions caused by anthracyclines lead directly to cardiotoxicity. We compared several biochemical parameters, including endogenous cellular respiration, adenosine and guanosine triphosphate levels, and 14C-amino acid incorporation, of rat hearts treated with doxorubicin and some of its derivatives, recent products of pharmacological research aimed at selecting less toxic antiblastic agents. In rats treated in vivo, we further examined the ultrastructural changes induced by anthracycline antibiotics in order to elucidate which biochemical parameters were consistent with the morphological lesions. Our data indicate that mitochondria are the target of the anthracycline effects and that oxygen uptake and nucleotide levels may be regarded as markers of the toxicity when evaluating new drugs before their clinical use. The lack of cytoplasmatic or endoplasmatic reticulum alterations may account for the failure of anthracyclines to affect amino acid incorporation. In any event, the rate of protein synthesis cannot serve as a marker of cardiac toxicity. In this context, epidoxorubicin and iododoxorubicin are two derivatives characterized by less cardiotoxic potential than doxorubicin and thus appear to be promising antiblastic agents.
ISSN:0030-2414
DOI:10.1159/000226952
出版商:S. Karger AG
年代:1991
数据来源: Karger
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14. |
Comparative Pharmacokinetics of Chlorambucil and Prednimustine after Oral Administration |
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Oncology,
Volume 48,
Issue 4,
1991,
Page 334-342
Ulrich Loos,
Eugen Musch,
Mouhammad Malek,
Eberhard Riedel,
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摘要:
The pharmacokinetics of chlorambucil, phenylacetic acid mustard (the β-oxidation product of chlorambucil), and prednisolone were investigated in a cross-over study after oral administration of chlorambucil (30 mg) + prednisolone (50 mg) versus prednimustine (300 mg), the ester of chlorambucil and prednisolone. Intact prednimustine could not be detected in plasma at any time. After administration of prednimustine, the plasma concentration-time curves of chlorambucil, phenylacetic acid mustard, and prednisolone showed a retarded profile compared to the administration of the single components. The mean bioavailability was 14% for chlorambucil, 21% for phenylacetic acid mustard, and 22% for prednisolone, when given as prednimustine, compared to the administration of free compounds in stoichiometrically equivalent doses. When given in the oral dosages mentioned above, the average dose-intensity was 62% for chlorambucil, 95% for phenylacetic acid mustard, and 72% for prednisolone, indicating sufficient therapeutic concentrations of the detectable agents
ISSN:0030-2414
DOI:10.1159/000226953
出版商:S. Karger AG
年代:1991
数据来源: Karger
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15. |
Flowcytometric Measurement of the Cell Cycle of Experimental Tumors: Some Devices for Accurate Measurement of Proliferative Activity |
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Oncology,
Volume 48,
Issue 4,
1991,
Page 343-346
M.T. Tsugita,
T. Tsuru,
T. Takasaki,
N. Shinomiya,
S. Kobayashi,
F. Hanyu,
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摘要:
In this paper we present the cell cycle analysis using the latest flowcytometer, FACScan and dedicated softwares. Although the 5-bromodeoxyuridine (BrdU) and anti-BrdU method developed by Gratzner has become popular for analysis of cell kinetics, contaminating interstitial cells and cell doublets are still factors responsible for some mistakes in measuring the cell cycle accurately. These hampering cells were almost gated out on the catogram consisting of the forward scatter and DNA content (propidium iodide, PI). After that, the bivariate distribution of BrdU and PI according to the tumor growth showed reliable patterns. In LLC tumor the population, of which DNA content was compatible with S phase cells, was detected in the cytogram. Thus, the two-dimensional analysis of the cell cycle can demonstrate each population clearly. The results obtained from the BrdU method are more beneficial than autoradiography or microspectrophotometry, and reproducible data of the cell cycle parameters can be acquired with some devices described here.
ISSN:0030-2414
DOI:10.1159/000226954
出版商:S. Karger AG
年代:1991
数据来源: Karger
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16. |
Carcinogenic Effect of Force-Feeding an Extract of Black Pepper(Piper nigrum)in Egyptian Toads(Bufo regularis) |
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Oncology,
Volume 48,
Issue 4,
1991,
Page 347-350
M.M. El-Mofty,
V.V. Khudoley,
M.H. Shwaireb,
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摘要:
50 male and 50 female Bufo regularis were treated, by force-feeding, with an extract of black pepper, at a dose level of 2 mg, 3 times a week for 5 months. The first tumors appeared after 2 months. Liver tumors (hepatocellular carcinomas, lymphosarcomas and fibrosarcomas) were found in 12 males and 18 females. Metastatic deposits of hepatocellular carcinomas were registered in the spleen, kidney, fat body and ovary.
ISSN:0030-2414
DOI:10.1159/000226955
出版商:S. Karger AG
年代:1991
数据来源: Karger
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17. |
Book Reviews |
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Oncology,
Volume 48,
Issue 4,
1991,
Page 351-352
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PDF (956KB)
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ISSN:0030-2414
DOI:10.1159/000226956
出版商:S. Karger AG
年代:1991
数据来源: Karger
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