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| 11. |
Macrophage Colony-Stimulating Factor for Cancer Therapy |
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Oncology,
Volume 51,
Issue 2,
1994,
Page 198-204
Kazuo Motoyoshi,
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PDF (2598KB)
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摘要:
Macrophage colony-stimulating factor (M-CSF) is a homodimeric glycoprotein which stimulates differentiation of progenitor cells to mature monocytes and enhances production of hemopoietic growth factors from mature monocytes such as granulocyte-macrophage CSF, granulocyte CSF and megakaryocyte potentiator, suggesting that M-CSF administration enhances production of monocytes, neutrophils and platelets. Since the commercial availability of M-CSF in 1991, serial M-CSF infusions at a daily dose of 8 million units have been performed in patients with acute myeloid leukemia in complete remission after combination chemotherapy. Although M-CSF infusion reduced the duration of neutropenia in 3 of 5 patients, it reduced the duration of pyrexia over 37°C in all patients, and that over 38°C in 4 of 5 patients. Average durations of pyrexia and parenteral antibiotic injections were significantly shorter in M-CSF than in control courses. Although M-CSF infusion reduced the duration of thrombopenia in 2 of 5 patients, it reduced total platelet units transfused in 4 of 5 patients. The average number of platelet units transfused after combination chemotherapy was significantly lower in M-CSF than in control courses. In mice, M-CSF injection increased the serum concentration of reactive nitrogen intermediates which inhibited the growth of L1210 cells, and increased the survival rate of mice previously injected with them. These results indicate that M-CSF may be a promising agent not for improving patients’ quality of life after cancer chemotherapy, but also in cancer immunother
ISSN:0030-2414
DOI:10.1159/000227334
出版商:S. Karger AG
年代:1994
数据来源: Karger
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| 12. |
Stem Cell Factor Is a Potent Synergistic Factor in Hematopoiesis |
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Oncology,
Volume 51,
Issue 2,
1994,
Page 205-214
George Morstyn,
Sherri Brown,
Michael Gordon,
Jeffrey Crawford,
George Demetri,
William Rich,
Brian McGuire,
MaryAnn Foote,
Ian McNiece,
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PDF (2724KB)
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摘要:
Stem cell factor (SCF), a ligand for c-kit, has a broad range of activities including effects on cells at or near the level of the multipotential stem cell as well as on committed cells. Preclinical studies show that SCF can protect against lethal irradiation, elicit multilineage responses in peripheral blood and bone marrow cellularity, and increase circulating peripheral blood progenitor cells (PBPC) in a dose-dependent manner. Recombinant human SCF has major clinical potential through its synergy with other factors, especially recombinant human granulocyte colony-stimulating factor, to enhance mobilization of PBPC.
ISSN:0030-2414
DOI:10.1159/000227335
出版商:S. Karger AG
年代:1994
数据来源: Karger
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