摘要:

Adult female Sprague-Dawley rats fed with 0.06% N-2-fluorenylacetamide presented an augmentation of plasma α-fetoprotein 2 days after the beginning of the experiment. This very early synthesis of α-fetoprotein was concomitant with the penetration of N-2-fluorenylacetamide detected by fluorescence microscopy, in the cytoplasm of the hepatocyte

ISSN:0030-2414    

DOI:10.1159/000225520

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The immunodepressive effect of a single, carcinogenic dose of dimethylnitrosamine was tested in a potent model of renal cancer induction using two antigens which differ in their cellular processing. Responsiveness to sheep red blood cells (SRBC), an antigen requiring the collaboration of both thymus-dependent (T) and thymus-independent (B) lymphocytes was determined by a plaque-forming assay; antibody production to Brucella abortus antigen, a thymus-independent antigen, was measured in an agglutination test. The results suggested that DMN exerted little or no effect on B lymphocytes in the anti-Bruc antibody assay, but a substantial deleterious effect on T-B cell collaboration as assessed in the anti-SRBC antibody response. This effect commenced immediately following the carcinogenic insult from 24 h, with a degree of depression for the first 10 days equivalent to antilymphocyte globulin in terms of numbers of anti-SRBC antibody-forming cells. From 2 weeks there was gradual recovery with full restoration of normal responsiveness at 8 weeks. During the ensuing period of emergence of neoplastic foci in the kidney, and with the progression of such foci to tumors of macroscopic dimensions, there was no accompanying depression of antibody response. The differential effect was discussed in terms of selectivity of action, and lymphocyte subsets.

ISSN:0030-2414    

DOI:10.1159/000225521

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The chemotherapeutic effects of different doses of adriamycin in (C3H × 020)F1 mice bearing mammary carcinoma have been investigated and a model of the growth of neoplastic cells under the influence of treatment is described. An estimate of cell kill and of the fraction of cells surviving after treatment is given by the efficacy constant K, which is a function of the dose level of the drug. The therapeutic value of each treatment is, however, also related to the degree of toxicity which in our model is expressed by the probability of death for each dose level

ISSN:0030-2414    

DOI:10.1159/000225522

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000225523

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000225524

出版商:S. Karger AG    

年代:1981

数据来源: Karger