摘要:

This study undertaken by the Central Clinical Drug Evaluation Program includes 682 evaluable patients, undergoing 871 courses of imidazole carboxamide with 39 different types of malignant disease. Toxicity consisted of nausea and vomiting for the first few injections, and hematopoietic depression in a relatively small group. A response of 25.1% was noted in 393 patients with melanoma. At the current dosage the drug seems to be well tolerated and is useful in the treatment of metastatic melanoma.

ISSN:0030-2414    

DOI:10.1159/000224680

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

44% of female patients with disseminated breast cancer responded to systemic chemotherapy with 5-fluorouracil 5-Fluorouracil (5-FU). This tumor response was associated with a prolongation ofHydroxyurea effective survival. Chemotherapy response appeared relatively in Medications dependent of the menstrual status of the patient, or of her response Toxicity to hormonal therapies. Women with less than a 1-year free interval Survival between the primary and recurrent tumor had a lower response rate. The patients who responded to adrenalectomy also responded to chemotherapy. Adrenalectomy was no contraindication to chemotherapy, although the adrenalectomy non-responders may never receive chemotherapy. There were no toxic deaths in this series. Malignant effusions responded well to intracavitary and systemic 5-FU.

ISSN:0030-2414    

DOI:10.1159/000224681

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000224682

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000224659

出版商:S. Karger AG    

年代:1972

数据来源: Karger