摘要:

The Ca, Mg and P concentrations in experimental animal tumors as well as in human tumors were determined analytically. When these results were compared with 32P and 45Ca uptake values, it is inferred that Ca is incorporated slowly into the insoluble fraction, and that each type of tumor presents a characteristic pattern of chemical fractionation, which also is reflected in other tissues of the animal. The insoluble calcium has been found to be located in the cytoplasm.

ISSN:0030-2414    

DOI:10.1159/000224570

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The possible participation of anions as bicarbonate, oxalate and citrate in the tumor’s insoluble calcium formation has been studied. Despite the possible coprecipitation of those anions, it seems that glycolysis products are the main precipitating agents. Our glycolysis experiments show that the higher the calcification of the tumors, the higher the amount of those glycolysis intermediates found in the insoluble fractions. Calcification also appears to lower the metabolic rate (glycolysis) of the tumor. Because of its low solubility and the direct relationship it has with other metabolic processes which normally were impaired in the tumors, α-ketoglutaric acid seems to be the most probable calcium-precipitating compound.

ISSN:0030-2414    

DOI:10.1159/000224571

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Thirty-one patients with malignant melanoma and 22 patients with other neoplasms were treated with intravenous 5-(3,3-dimethyl-triazeno) imidazole-4-carboxamide (DIC), utilizing 2 different regimens: a 5-day daily schedule of 150 to 300 mg/M2/day of DIC repeated every 14 days, or 350 to 450 mg/M2 given twice weekly. Ten objective responses were seen, including 6 (24%) with melanoma. Toxicity consisted mainly of vomiting and bone marrow depression. Since the twice-weekly regimen appeared to be less toxic than and equally effective as the daily protocol, we conclude that a twice-weekly schedule of DIC should be further explored in the therapy of melanoma and other solid tumors.

ISSN:0030-2414    

DOI:10.1159/000224572

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Survival after severe hyponatremia (serum sodium 125 mEq/l) and hypochloremia (serum chloride 78 mEq/l) is described in an adult with acute leukemia who received toxic doses of vincristine. Transient confusion and prostration accompanied the electrolyte abnormalities. Laboratory evidence of CNS leukemia was not present. The patient with supportive care improved rapidly within two days as the electrolytes gradually returned toward normal; the electrolytes became entirely normal on the fifth day. Stringent sodium chloride replacement was not required to correct the hyponatremia and hypochloremia. Although rare, vincristine-induced hyponatremia and hypochloremia constitute a serious complication that warrants prompt recognition and supportive medical care.

ISSN:0030-2414    

DOI:10.1159/000224573

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

(1) The amino acid inhibition of alkaline phosphatases is a concentration-dependent, reversible process. (2) Isoenzymes from different organs and tumours have definite and reproducible patterns of amino acid inhibition in vitro. The use of 5 different amino acids (l-Phe, l-Arg, l-Homoarg, l-Met and l-Val) made it possible to establish such a pattern. (3) The enzymes in tumours are more sensitive to amino acid inhibition in vitro than those in their corresponding normal tissues. Different tumours show different amino acid inhibition patterns; there is no common tumoui type of alkaline phosphatase according to this criterion. (4) In the enzyme mixtures such as are found in human serum (unless one variant is present in an unusually high proportion) the individual components seems to influence mutually their respective characteristics in such a way that single variants cannot be distinguished, or their source traced with certainty.

ISSN:0030-2414    

DOI:10.1159/000224574

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Evidence has been obtained to demonstrate that Yoshida hepatoma cells subcutaneously (s.c.) or intramuscularly (i.m.) injected into Wistar rats can grow and multiply to give raise to a tumour mass. This tumour is subsequently rejected with an immunological mechanism mainly sustained by lymphoid and immunocompetent cells.

ISSN:0030-2414    

DOI:10.1159/000224575

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Some terrestrial Tricladids, like Geoplanaabundans, develop unusual regeneration processes in the course of replacing lost parts of their integument. Specimens fixed in 5 consecutive stages of generation show the following phenomena: first formation of a membrane over the wound; then establishment of a plasmodial covering layer under the membrane through re-utilization of various tissue fragments; then migration of nuclei into this layer and their adjustment to the new position; finally formation of a complete integument without cellular structure but with clear delimitation from the other tissues by a basal membrane. No neoblasts participate in the formation of this integument but later an immigration and vigorous multiplication of neoblasts take place, always below the basal membrane. Still later the plasmodial integument itself also takes up a definite cellular structure. The possible role of similar phenomena in the pathological histology of higher organisms is pointed out.

ISSN:0030-2414    

DOI:10.1159/000224576

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Threads impregnated with 20-methylcholanthrene and beeswax, or with pure beeswax, were implanted into the cervical canal and one of the uterine horns of 6-week-old mice. After 4- and 6-weeks’ treatment it was noted that the cervical stratified epithelium extended cranially into the uterine horn containing the thread. Early squamous carcinomas occurred in 58% of the treated animals, and they invariably occurred within an area of benign squamous stratified epithelium, sometimes caudal to the level of the original squamocolumnar junction, sometimes at the level of the original junction, but most frequently cranial to it in the area of newly-formed stratified epithelium. It is concluded that all squamous tumors originated from the cervical stratified epithelium, and that none arose by metaplasia and neoplastic transformation of columnar cells, or from any other component of the uteru

ISSN:0030-2414    

DOI:10.1159/000224577

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

A variety of cytochemical procedures revealed that, as the Ehrlich ascites tumor cell population increased in size and age during intraperitoneal growth, lipid accumulated intracellularly. This increase in the number of lipid droplets per cell was reversible when the tumor cells were induced to undergo rapid or recurrent growth. The decrease in the quantity of lipid per cell during recurrent growth was associated with a marked increase in lipase activity. The cyclic accumulation and loss of cytoplasmic lipid droplets in Ehrlich cells is discussed.

ISSN:0030-2414    

DOI:10.1159/000224578

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000224611

出版商:S. Karger AG    

年代:1971

数据来源: Karger