摘要:

Primary breast cancer tissue and lymph nodes were obtained from 55 patients. Histologically, 34 of these patients had positive and 21 negative lymph nodes. Estrogen receptors (ER) and progesterone receptors (PR) were determined by a dextran-coated charcoal assay. The tumor tissue was ER positive in 58% of the cases and PR positive in 34%. The malignant lymph nodes were ER positive in 56% and PR positive in 24%. ER in 14% and PR in 5% of the benign lymph nodes could be detected. The primary tumor tissue and the corresponding malignant lymph nodes showed an identical ER and PR status, i.e. both tumor sites were receptor positive or both receptor negative, in 68 and 74%, respectively. However, 21% of the patients had receptor-positive tumors but receptor-negative lymph nodes. Receptor-positive lymph nodes in combination with receptor-negative tumors occurred in only 11% for ER and 6% for PR. These data show that receptor-positive malignant lymph nodes mostly display the same receptor status as the corresponding primary tumor, whereas receptor-negative lymph nodes may be combined with receptor-positive tumors.

ISSN:0030-2414    

DOI:10.1159/000225666

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

The existence and the concentration of the estradiol receptor (ER) in breast cancers of pre- and postmenopausal patients were measured. ER status and concentration are significantly higher in cancers of postmenopausal women. Breast cancers operated at various phases of the menstrual cycle showed remarkable differences in ER incidence and concentration. The highest values were found in the early proliferative phase, whereas the ER incidence is lowest in cancers which were operated at early secretory phase. ER concentrations found in late proliferative and late secretory phases are significantly lower than those found in cancers of postmenopausal patients. Statistically significant differences of the ER concentrations between the various phases of the menstrual cycle could not be secured.

ISSN:0030-2414    

DOI:10.1159/000225667

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Lymphosarcomas are the most frequent forms of primary pulmonary sarcomas. A comparison has been made between a total of 121 primary lymphatic sarcomas of the lungs and 314 other histomorphological forms of primary sarcomas of the lungs found in the literature in 15 years, out of which 7 are our own cases. Our results are summarized in a table, which shows the differences. Histomorphology, clinic and prognosis are discussed with special emphasis. The average age is 52 years, the age period 4–80 years, the sex distribution 1:1, the localization of the right side of the lungs 71%, the rate of recidives 4%, the general metastasing 23%, the number of patients who survived the 5-years limit postoperatively 26.5%. An attempt is made to explain the postoperatively often unusually favorable development of these primarily malignant tumors by the histomorphological and pathophysiological characteristic

ISSN:0030-2414    

DOI:10.1159/000225668

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

The technique and preliminary results of cryosurgery in 15 patients with penile carcinoma in stage T1–3N0M0 are presented. All the patients but 1 were free of their disease for more than 3 years. In 1 case repeated cryosurgery resulted in cur

ISSN:0030-2414    

DOI:10.1159/000225669

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

This paper presents clinical observations on 130 patients with carcinoma of the pancreas, including 19 with periampullary cancer, the first large study of this disease in Iraq. All of the patients were admitted to the First (one of three) Surgical Unit of the University of Baghdad Teaching Hospital (the Medical City) during the period 1965–1977. The diagnosis and extent of disease were confirmed surgically in all patients. The clinical presentation, histopathologic characteristics, and prognostic features of the disease in Iraq seem no different from those seen in other parts of the world. Though relatively uncommon (1.4% of all male and 1.2% of all female cancers in the Baghdad Cancer Registry), cancer of the pancreas is the second most common tumor of the digestive system, next to that of the stomac

ISSN:0030-2414    

DOI:10.1159/000225670

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Rapidly progressing hypercorticism was observed in 2 patients with malignant neoplasms, a 72-year-old man with anaplastic small cell carcinoma and a 48-year-old woman with a primary apudoma of the liver. Both patients were treated with chemotherapy in conventional doses. Both patients developed acute dyspnea and sudden death, 7 and 10 days, respectively, after chemotherapy was given. The possibility that patients with ectopic adrenocorticotropic hormone (ACTH) secretion are excessively vulnerable to chemotherapy is raised and judicious management urged.

ISSN:0030-2414    

DOI:10.1159/000225671

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Crocetin seems to have a small effect in slowing the development of skin tumors induced in hairless mice by the application of dimethyl-benz-a-anthracene and croton oil. No definite effect is shown on preventing the development of tumors induced by UV-B radiation.

ISSN:0030-2414    

DOI:10.1159/000225672

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

The rate of disappearance of nicotine from mouse skin was increased by the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) during the first 2-hour period following the application of nicotine to mouse skin. The biological half-life (t½) for nicotine alone was 1.2–1.3 h whereas in the presence of TPA, t½ was 0.8 to 0.9 h. The disappearance of nicotine from mouse skin followed first-order kinetics over a period of 6 h whereas the loss of nicotine in the presence of TPA from mouse skin followed first-order kinetics for the first 2 h, then the nicotine level became fairly constant for the time period of 2–5 h. Benzo(α)pyrene did not affect the rate of disappearance of nicotine from mouse skin. Neither cotinine nor nicotine 1′-N oxide, metabolites of nicotine, was detected in mouse skin following the topical application of this

ISSN:0030-2414    

DOI:10.1159/000225673

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Homogenates of colonic mucosa from seven mouse strains metabolized 14C-benzo[α]pyrene (BP) to alkali-soluble and water-phase products. In those strains in which liver aryl hydrocarbon hydroxylase activity is inducible by β-naphthoflavone (β-NF), the C57BL/6, BALB/c, C3H and random-bred Swiss CD-1, colonic metabolism of BP was also induced by intraperitoneal treatment with 150 mg/kg β-NF 24 h before the assay. No increase in the colonic metabolism of BP was seen after β-NF treatment of the noninducible strains, AKR, DBA and SWR. A detailed study of the products formed was carried out with C57BL/6 male mice. High-performance liquid-chromatography analysis of the products of BP metabolism revealed that phenolic derivatives predominated, but that a small percentage of the BP was converted into the proximate carcinogen, the BP-7,8-diol. Addition of uridine 5′-diphosphoglucuronic acid to the incubation mixture caused an increase in total product formation and a shift from alkali-soluble to water-phase products. Of the water-phase products formed by β-NF-induced colonic mucosal homogenates, about 40% were nondialyzable and associated with precipitable material. In a study of the cellular effects of BP on the colonic mucosa, intrarectal administration of 1 mg BP had a significant cytotoxic effect, as indicated by the number of pyknotic cells and 3H-thymidine-labeling index, and prior treatment with β-NF afforded significant protection against this cyto

ISSN:0030-2414    

DOI:10.1159/000225674

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Ligandin was decreased by 75% as determined immunologically and by glutathione-S-transferase or steroid isomerase activities in rat hepatocellular carcinomas induced by exposure to N-2-fluorenylacetamide. Minor variable differences in ligandin levels were noted between the putative, premalignant nodules induced by this regimen and normal liver.

ISSN:0030-2414    

DOI:10.1159/000225675

出版商:S. Karger AG    

年代:1982

数据来源: Karger