摘要:

From 1976 to 1985, 61 consecutive patients with locally advanced breast cancer were treated with multimodality therapy. Overall 5-year survival was 30% with a median survival of 36 months. 50% of patients relapsed within 13 months. Other factors such as menopausal status, side of illness (right or left breast), responses to systemic or to local treatment, survival and progression-free survival in responders and non-responders have been analyzed.

ISSN:0030-2414    

DOI:10.1159/000226463

出版商:S. Karger AG    

年代:1987

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000226464

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The reactivity of mononuclear cells from patients with breast cancer to the 3 M KCl extract of breast tumor was tested using the superoxide (O2––) assay monocyte adherence test. The mononuclear cells were incubated with the 3 M KCl extract of breast tumor or normal breast tissues in a microcell for spectrophotometer analysis. After 2 h incubation, the nonadherent cells were removed, and the O2–– generated from the monocytes adherent to the intersurface of the microcell was assayed. Thirty of 36 patients with breast cancer before treatment reacted to the extract of breast tumor. Sixteen patients showed adherence inhibition and 14 adherence stimulation. None of 8 patients with breast cancer reacted to the extract of lung tumor. Of 31 control donors (19 healthy volunteers and 12 patients with cancer of other organs), only 3 reacted to the extract of breas

ISSN:0030-2414    

DOI:10.1159/000226465

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The serum immunoreactive calcitonin (ICT) concentration was estimated in 107 patients with lung cancer of various cell types, 46 normal subjects and 24 non-cancer patients with various pulmonary diseases. Eighty-one of the cancer patients had localized lung cancer and the rest 26 primary lung cancer with metastases to other organs. The ICT was found significantly increased in the lung cancer patients. The highest ICT values were found in patients with lung cancer and metastases to other organs, especially to the liver. In localized disease, patients with small-cell carcinoma of the lung showed the highest, while those with adenocarcinoma and squamous-cell type demonstrated the lowest ICT concentrations. In 46 patients with lung cancer, serial determinations of serum ICT levels showed significantly decreased calcitonin levels in the patients who responded well to therapy with cytostatics, X-rays or both after more than 2 months of therapy. Fluctuations of ICT levels were in agreement with the regression or progression of the disease.

ISSN:0030-2414    

DOI:10.1159/000226466

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The human tumor clonogenic assay (HTCA) has potential value for studies of both the chemosensitivity and biology of human tumors. However, many technical problems including low plating efficiencies and the preparation of sufficient numbers of viable cells remain. In this study, an improved method for disaggregation of solid tumors increased the yield of single cells. Consequently, more than 10 anticancer drugs could be tested in 94 of 168 specimens (56%). Removal of peripheral blood lymphocytes from cell suspensions derived from effusions also improved colony formation. Adequate growth for sensitivity testing (>30 colonies/plate) was obtained in 122 cases (73%), inadequate growth for drug evaluation (5-29 colonies/plate) in 29 cases (17%), and no colony formation (<5 colonies/plate) in 17 cases (10%) of the 168 viable samples. The cloning efficiencies of cells derived from primary tumors (median 0.015%) were higher than those of cells derived from metastatic tumors (0.012%), and they varied with the location of the metastatic site. Clonig efficiencies varied markedly from specimen to specimen, and were unaffected by tumor histology, grade of differentiation, patient age, stage of disease, or prior chemotherapy. The HTCA is promising as a potential tool for studying the biology of tumors.

ISSN:0030-2414    

DOI:10.1159/000226467

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The rising incidence of malignant melanoma is associated with a change in the stage at presentation. As a result more deaths can now be expected in stage I patients, despite their overall better prognosis. More accurate staging, with regional node dissection, is needed if these ‘at risk’ patients are to be identified earlier. This need will become more acute as suitable adjuvant chemotherapy and other regimes become availa

ISSN:0030-2414    

DOI:10.1159/000226468

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Aclacinomycin A (ACM) in a daily dose of 30 mg/m2 was infused over 1 h on 4 consecutive days to 50 patients. Myelotoxicity was acceptable, nausea and vomiting was frequent, hair loss was mild. Grade 1–2 cardiac rhythm abnormalities were observed in 12% of the patients. Between days 1 and 4 the heart rate and the corrected Q-T interval increased while the amplitude of the T wave decreased significantly, cardiac contractility remained unchanged. In 24 evaluable breast cancer patients 1 complete remission (4%) and 2 partial remissions (8%) lasting for only 2–3 months were seen. None of the 8 patients suffering from ovarial cancer benefitted from ACM ther

ISSN:0030-2414    

DOI:10.1159/000226469

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

C-band heteromorphisms of chromosomes 1, 9 and 16 were studied in 62 patients with cervical cancer, 100 women with various grades of precancerous lesions and 47 normal women as controls. The data showed an increased frequency of heteromorphisms of chromosome 1 in patients with cancer (48.39%) and severe dysplasias (40%) as compared to controls (29.8%) and lower grades of dysplastic lesions, i.e. mild and moderate (28.8%). The increase in the incidence of chromosome 1 heteromorphisms in cancer was found to be statistically significant (p <0.05) compared to controls. The present study indicates that C-band heteromorphisms may play some role in the development of malignancy of the uterine cervix. cerous and cancerous lesions along with age-matched controls to see if there is any association with cervical cancer.

ISSN:0030-2414    

DOI:10.1159/000226470

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

We examined the antitumor effect of vitamin B12 (methyl-B12) using C3H/He, C57BL/6 and BALB/C mice for animals and MH134 hepatoma ascites cells, Lewis lung cancer cells and Ehrlich ascites tumor cells for tumor cells. At 1.0–10 μg/ml, methyl-B12 enhanced PHA- and Con-A-induced lymphocyte blastoformation of C3H/He mice. The growth of MH134 tumors on the backs of C3H/He mice were suppressed by the 7-day administration of 50 or 100 μg/day i.p. and their survival was longer than that of untreated mice. However, methyl-B12 administration did not positively affect the survival of C3H/He mice that had been irradiated with 60Co 300 R on the day before tumor cell inoculation. The growth of Ehrlich ascites tumor cells inoculated into BALB/C mice was also reduced at 17 and 19 days after tumor inoculation by administration of methyl-B12 50 μg/day i.p. and the mice survived longer than the untreated

ISSN:0030-2414    

DOI:10.1159/000226471

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The ectopic production of human choriogonadotropin (hCG) and its free α- and β-subunits was evaluated in 195 patients with nongestational malignancy. Dimer hCG was the predominant species secreted. Significant levels of free β-hCG were detected in 11% of patients, and represented 1.6–12% of immunoreactive hCG. In these patients the ratio of free β-subunit to hCG remained constant during their follow-up period. Significant levels of free α-hCG occurred in 1.5% of patients, but were secreted independently of free β-hCG. These findings indicate that immunoassays specific for dimer hCG would not be significantly disadvantaged in monitoring malignancy, and that free β-hCG subunit levels have limited application as a tumo

ISSN:0030-2414    

DOI:10.1159/000226472

出版商:S. Karger AG    

年代:1987

数据来源: Karger