摘要:

Prednimustine (Leo 1031), a conjugate of prednisolone and chlorambucil, was administered to humans and baboons and the metabolic fate of the compound ascertained. Compared to the excretion of prednisolone, prednimustine is excreted more slowly and less quantitatively, with a significant part of the compound being retained in the body. Hydrolysis of the prednimustine molecule appears to take place quantitatively after oral administration, but a substantial part of prednimustine appears to remain intact after its intravenous administration. Fecal excretion of radioactivity was minor compared to the urinary route. The biliary excretion in the baboon was relatively insignificant. Localisation within the lung and spleen of the baboon points to a potential therapeutic use of this drug in neoplastic conditions affecting these organs.

ISSN:0030-2414    

DOI:10.1159/000225254

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Tumor markers (TM) represent a critical area of clinical investigation in cancer management. The mechanism of TM production and release are discussed for the three classes of TM: non-endocrine tumor produced hormones, tumor associated antigens, and tumor related enzymes. The concept of TM as a means of screening large patient populations for detection of early cancer has not been worthwhile, related in part to the uncommon occurrence of elevated levels of circulating TM, and in part to the fact that TM are generally abnormally elevated in patients with advanced and clinically detectable disease. Tumor markers as sequential monitors or quantitative measures of disease and response to therapy have similarly demonstrated limited utility, related to the heterogeneity of the tumors and to the lack of a precise quantitative relationship between circulating TM levels and tumor volume or mass.

ISSN:0030-2414    

DOI:10.1159/000225255

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The transformed properties of five hybrid cell lines which had either one or another parent in common were studied and compared with their tumorigenicity. Three hybrid cell lines, derived from the Chinese hamster DC-3F/ADX/Aza line, were resistant to actinomycin-D. This property seemed to be correlated with the presence of a marker chromosome from the common parent. The tumorigenicity was intermediate between those of the parent cell lines. On the other hand, agglutinability by concanavalin A (Con A) was variable. Three hybrid cell lines which had either the A9 or the clone 1D (both derived from mouse fibroblasts) showed very similar transformed characteristics, but two were tumorigenic and one not so. It appears from this study that the properties of the hybrid cell lines can be influenced more by one parent, depending on the genes retained at chromosome segregation. The limits of Con A agglutination as a characteristic of transformation and the validity of the check pouch grafts as tumorigenicity test for malignant human cell lines are discussed.

ISSN:0030-2414    

DOI:10.1159/000225256

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Peripheral blood lymphoid cells from normal donors, patients with non-malignant diseases, and patients with malignant diseases were evaluated for cytotoxicity against a cultured carcinoma cell line, using a chromium release assay. The natural spontaneous lymphocyte-mediated cytotoxicity was significantly higher in tumor-free groups. The observed decreased response in patients with malignancies correlated with depressed responsiveness to phytohemagglutinin stimulation. Removal of cell subpopulations bearing Fc receptors significantly decreased the cytotoxicity, while depletion of phagocytic mononuclear cells did not. We suggest that natural cytotoxicity is a measure of cell membrane integrity of lymphocytes and should be included as a routine test for evaluation of general immune competence.

ISSN:0030-2414    

DOI:10.1159/000225257

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Normal family members of eight patients with paraproteinemia of the primary intestinal lymphoma, had been investigated by Immunoelectrophoresis, for IgA heavy chain pattern. IgA heavy chain pattern was demonstrated in four families only, of different members, but all are of the first degree relationship. Detailed clinical, laboratory, radiological and histopathological findings of those eight cases were suggestive of malabsorption. Out of the 129 normal family members of the 8 cases, 23 cases (17.8%) had abnormal immunoglobulin in their sera. These results may explain a hereditary factor which is responsible for production of alpha-chain diseases. Supports for this hypothesis need further research.

ISSN:0030-2414    

DOI:10.1159/000225258

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Cytoplasmic tyrosine aminotransferase (L-tyrosine: 2-oxoglutarate aminotransferase, EC2.6.1.5) was partially purified from host liver and Morris hepatoma No. 7777 grown in pyridoxine depleted rats. The animals were sacrificed six hours following the intraperitoneal administration of hydrocortisone hemisuccinate. Enzyme preparations were subsequently resolved by electrophoresis on poly-acrylamide gels. Enzyme activity was detected histochemically in situ on the gels. Six and at least three enzymatically active protein peaks were detected in host liver and the hepatoma, respectively, by this method.

ISSN:0030-2414    

DOI:10.1159/000225259

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

A growth inhibitory effect on adenocarcinoma TA3 ascites tumors in LAF1/J mice resulted from the repeated IP administration of subtoxic doses of 3 rifamycin derivatives: rifampicin (Rif)1, dimethylbenzyldesmethylrifampicin (DMB), and rifazone-82 (R-82). A high-viscosity methylcellulose vehicle was found to be essential for obtaining a uniform drug suspension and a significant antitumor effect by the least water soluble derivatives, DMB and R-82. The more hydrophilic derivative, Rif, was found to have a comparable growth inhibitory effect on TA3 cells when prepared in 0.9% NaCl solution with or without added methylcellulose. Oral or SC drug injections did not have an antitumor effect. The results of this study point to the importance of vehicle and route of administration in chemotherapy trials with these compounds.

ISSN:0030-2414    

DOI:10.1159/000225260

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The case of a 47-year-old white female patient has been described with malignant melanoma that started as a node on her right ankle twelve years ago and regressed spontaneously. During the last two years of her life, dissemination of the melanoma appeared in the form of subcutaneous nodes, which regressed spontaneously in successive crops. In the course of her disease there was evidence of distant metastases to the brain. Spontaneous regression seems to have been enhanced by immunotherapy, when most of the metastases had regressed, including those in the brain.

ISSN:0030-2414    

DOI:10.1159/000225261

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

This paper analyses the distribution of metastases at every site of the human body in acute lymphoblastic, chronic lymphocytic, acute myeloblastic and chronic myelocytic leukemias in patients that come to autopsy. It appeared that the 4 types of leukemia had a similar seeding frequency of the skin, breast, trachea, diaphragm and all other muscles. The highest incidence of metastases was found in the lymphatic system (i.e. all lymph-nodes and spleen). Acute lymphoblastic leukemia showed an excess of metastases in the major blood vessels, pleura, large intestines, extrahepatic biliary tract, ureters, prostate, cervix uteri, central nervous system, thymus, ovaries and pituitary. The excess of metastases at specific sites did not cluster either in topographical areas or in anatomical systems, with the exception of metastases in the central nervous and endocrine systems (acute lymphoblastic leukemia). Chronic lymphocytic leukemia showed an excess of metastases in all lymph nodes, kidney, adrenals and heart. A lymphatic route of dissemination, as opposed to a blood-borne spread of malignant cells, was hypothesised to account for the excess of metastases in the above mentioned organs in patients affected with chronic lymphocytic leukemia. Soil specificity with the degree of anaplasia of leukemic cells may account for the higher than expected occurrence of metastases in a given organ, for a specific leukemia. This remark holds true particularly for acute lymphoblastic leukemia.

ISSN:0030-2414    

DOI:10.1159/000225262

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000225263

出版商:S. Karger AG    

年代:1978

数据来源: Karger