摘要:

The cell-differentiating agents (inducers) dimethylacetamide, dimethylurea and tetramethylurea significantly lowered the yields and/or incidences of total tumors, benign plaques, benign hyperkeratotic lesions and advanced tumors promoted by retinyl acetate or croton oil after initiation by 7,12-dimethylbenz(a)anthra-cene. The percentage of plaques was increased by the inducers suggesting that they inhibited progression of plaques to more advanced tumors. These results suggest that topical application of inducers might have therapeutic potential in epidermal carcinoma.

ISSN:0030-2414    

DOI:10.1159/000225406

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Circulating immune complexes were determined in patients with lung cancer by the Clq deviation test and by column chromatography on Sepharose 6 B. Immune complexes could be demonstrated by the two different methods in 50–80% of patients’ sera at the time of diagnosis. Patients with extended disease had more immune complexes than patients with limited disease. Serial determinations showed a good correlation between immune complex levels and clinical course of disease. The size of the immune complexes present in patients’ sera was determined by sucrose density ultracentrifugation and by column chromatography in the region between 10 S and 30 S. Furthermore in this study no inhibition of antibody-dependent cell-mediated cytotoxicity by circulating immune complexes could be

ISSN:0030-2414    

DOI:10.1159/000225407

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Benzo(a)pyrene (BP) was administered to Swiss mice in 1 and 10 weekly intracolonic instillations at 200 μg/g body weight. The single administration of BP induced a statistically significant incidence of malignant lymphomas and tumors of the forestomach, while its repeated instillation, evoked, in addition to these two tumor types, neoplasms in the esophagus, anus and skin. BP failed to elicit intestinal tumors, which was the main objective of the present investigation. We discuss, in light of the obtained results, the various experimental conditions under which studies were conducted of this most versatile and widely occurring carcinogen, to which a large segment of the human population is exposed

ISSN:0030-2414    

DOI:10.1159/000225408

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Several prostatic tissue DNAs have been examined for their content of simian-sarcoma-virus-related sequences. This was done by hybridizing fragmented prostatic DNA with simian sarcoma virus complementary DNA (cDNA) synthesized in vitro. The tissue DNAs contained limited amounts of virus-related sequences. The content ranged from about 10 to 60 pg of viral DNA per milligram of cell DNA, depending on the tissue. This corresponds to approximately one viral genome equivalent per 20–100 cell genomes. A clear correlation between viral DNA content and histopathology of the tissue – normal, hyperplastic and neoplastic – has not emerged from the tissue DNAs examined thus far. The trend appeared to be for the hyperplastic tissue to contain more virus-related sequences than normal or neoplastic tissue. The melting point of hybrids of prostatic DNA and viral cDNA was 15°C lower than that of native prostatic DNA. This can be interpreted to suggest that prostatic DNAs contain a distribution of short segments of sequences that hybridize with vira

ISSN:0030-2414    

DOI:10.1159/000225411

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Some properties and kinetics of synthesis of the carcinoembryonic antigen (CEA-LoVo) produced by an established human colon carcinoma cell line were analyzed. CEA-LoVo was assayed by the method of Chu and Reynoso 70% loss). The elution profile of CEA-LoVo in con-canavalin A-Sepharose B coincided with that of the First British Standard for CEA. No A or B blood group antigenic activity was noted. Studies employing immunofluorescent and horseradish peroxidase-labeled antibody techniques demonstrated heavy membrane and moderate intracytoplasmic localization. The greatest amount of net synthesis occurred for cells in stationary phase while CEA-LoVo release occurred maximally in lag ph

ISSN:0030-2414    

DOI:10.1159/000225412

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Murine lymphoid chalones and their in vivo effect were studied. Cytoplasmic extracts were prepared from normal murine spleen lymphocytes. When assayed in vitro, cytoplasmic extracts (CE) were able to inhibit a blastomitogenic phytohemagglutinin (PHA) response of syngeneic and allogeneic normal murine lymphocytes, as well as cell replication of murine lymphoma cells. CE also had an inhibitory effect on human lymphoblastoid cell line division but it had no effect on nonlymphoid cell division. In vivo, CE had an enhancing effect on a murine allogeneic tumor, probably by suppressing the host’s immune rejection respons

ISSN:0030-2414    

DOI:10.1159/000225413

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

One-way mixed lymphocyte reactions (MLR) were used to establish a correlation between loss of in vitro T cell reactivity and in vivo tumor growth. Though supernatants from anti-Thy 1 treated macrophages (MФ) greatly enhanced MLR activity in normal T cells, such addition had little effect in reversing the inability of T cells from 2-week palpable tumor-bearing mice (TBM) to recognize in vitro foreign histocompatibility antigens. Since normal T cells, exposed to TBM M0 supernatants, exhibited no decrease in proliferative response, TBM T cell loss of MLR reactivity could not be ascribed to tumor-induced suppressor M

ISSN:0030-2414    

DOI:10.1159/000225414

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

In vivo and in vitro survival and response of lymphocytes were studied in 12 lung cancer patients before, during and following radiotherapy, and comparisons were made to data from 20 healthy control subjects. Lymphocyte counts of lung cancer patients prior to radiotherapy did not differ significantly from those of control subjects. Following radiotherapy, lymphocyte counts were significantly reduced. The in vitro survival of lymphocytes from lung cancer patients prior to radiotherapy was lower than that of normal controls. Radiation treatment had no effect on lymphocyte survival in vitro. PHA-stimulated lymphoblast formation in lung cancer patients prior to radiotherapy did not differ from that of normal controls, but decreased significantly during radiotherapy.

ISSN:0030-2414    

DOI:10.1159/000225415

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

A history of prior total bilateral oophorectomy and exogenous estrogen use was elicited from 45 women with breast surgery for cancer, 19 of whose neoplasms were estrogen receptor (ER) positive and 26 ER negative. In the ER-positive group there was a history of oophorectomy in 0/19 and estrogen use in 3/19. In the ER-negative group, corresponding values were 8/26 and 12/26 (p < 0.05). Manipulation of the female hormonal milieu during or prior to the menopause may be related to the subsequent ER status of incident breast cancers.

ISSN:0030-2414    

DOI:10.1159/000225416

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

34 patients were treated for Ewing sarcoma with primary presentation. There were 10 females and 24 males with average age of 21 years (range 16–36 years). These patients received radiotherapy ( > 5,000 R) to the primary site and combination chemotherapy with vincristine, cyclophosphamide, doxorubicin and actino-mycin D. Of 19 patients with primary presentation in an extremity, 12 remain alive at 29 months without clinical evidence of tumor (63%); 2 patients are alive with relapse. All 10 patients with primary presentation in the pelvis died despite vigorous treatment. 3 patients are alive out of 5 patients with primary presentation in chest or abdominal wall or axilla but only 1 patient remained tumor-free. Of the entire group of 34 patients, 12 remained tumor-free at 27 months (35%). 2 relapsed patients were rendered surgically tumor-free and receive further treatment. 20 patients died or are receiving treatment for advancing disease. 16 patients were treated for locally recurrent (1 patient) or metastatic (15 patients) Ewing sarcoma. There were 6 females and 10 males (average age 24.7 years). These patients received palliative radiotherapy and combination chemotherapy with vincristine, cyclophosphamide, doxorubicin, actinomycin D and dacarbazine. At 36 months, 3 patients are alive tumor-free and 1 patient is alive with stable disease. 12 patients died, 2 after temporarily achieving complete remissio

ISSN:0030-2414    

DOI:10.1159/000225417

出版商:S. Karger AG    

年代:1980

数据来源: Karger