摘要:

The effects of tumor cells implanted into the brain of animals on survival rates and gross and microscopic brain changes have been ascertained. Walker carcinosarcoma 256 cell suspensions were injected at several brain sites in rats and leukemia L1210 and P388 and Ehrlich ascites tumor cells, intracerebrally into BDF1 mice. Such neoplasms provided for rapid and rather predictable growth increments. The survival rates were dependent on the number of cells introduced, those receiving the higher counts succumbing first. The brains of the animals revealed fairly discrete space-occupying lesions and neurological symptoms became apparent only hours before death due to intracranial pressure.

ISSN:0030-2414    

DOI:10.1159/000225000

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

A factor is revealed in the serum of both normal and cancer-bearing individuals which binds circulating tumor-specific antigens. This bond does not appear to be immunologic.

ISSN:0030-2414    

DOI:10.1159/000225001

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Eighty-eight patients with disseminated melanoma and 22 patients with various other solid tumors were treated with combination chemotherapy consisting of DTIC, at a fixed dose, with either adriamycin, CCNU, or hydroxyurea, at several dosages. An objective response rate of 20 % was observed in 84 evaluable melanoma patients. The addition of the other agents to DTIC did not provide enhanced antitumor activity. Combination chemotherapy increased toxicity. Encouraging objective responses were observed in patients with synovial sarcoma (4/7) and teratocarcinoma of the testis (1/1) treated with the combination of adriamycin and DTIC.

ISSN:0030-2414    

DOI:10.1159/000225002

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Fourteen long-term human malignant melanoma cell lines established from biopsy specimens, malignant effusions and the peripheral blood are reported. Methods of culture, heterologous transplantation studies and characterization of these cell lines are presented. Several of these cell lines have retained the ability to produce pigment over a period of years, permitting bioassays at a subcellular level. Studies of cell lines grown with and without tyrosine and some of the theoretical uses of human melanoma cell lines are presented.

ISSN:0030-2414    

DOI:10.1159/000225003

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Use of hydrazine sulfate potentiates the antitumor action of Cytoxan (cyclophosphamide), Mitomycin C, methotrexate and bleomycin against Walker 256 intramuscular carcinosarcoma in in vivo short-term studies in rats. Experimental data suggest this potentiation by hydrazine sulfate to result from a mechanism of action other than direct cytotoxicity, and further, that combination chemotherapy with hydrazine sulfate and a cytotoxic agent may be useful in the treatment of human cancer.

ISSN:0030-2414    

DOI:10.1159/000225004

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000225005

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000225006

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000225007

出版商:S. Karger AG    

年代:1975

数据来源: Karger