摘要:

1. For patients who are potentially curable of cancer of the breast, colon or ovary, radiotherapy can be an effective adjuvant to surgery. The accomplishments of such treatment include: control of regional tumor spread; reduction of metastases incident to manipulation; conversion of a few patients from being inoperable to being operable. Data documenting the contributions of modern radiotherapy are scarce. 2. For patients who, by current knowledge, are not curable of cancer of the breast, colon or ovary, radiotherapy can be an effective palliative agent. Good usage requires specific indications and contraindications, modern techniques, minimization of treatment-produced morbidity, cost and inconvenience.

ISSN:0030-2414    

DOI:10.1159/000224516

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Serum TSH levels, determined by a very sensitive immunofluorescent assay, were found to be consistently higher in euthyroid individuals with thyroid cancer than in normal persons or those with other thyroid diseases or with non-thyroidal cancers. Thyroid cancer patients required larger thyroxin doses for TSH suppression than controls. From these studies it appears that chronic TSH stimulation, long known to produce thyroid cancer in experimental animals, may also play a causative role in human thyroid cancer.

ISSN:0030-2414    

DOI:10.1159/000224517

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Magnesium Pemoline, a central nervous system stimulant and highly effective radioprotective agent was found to alter the growth pattern and morphology of Ehrlich tumor cells with or without the additional effect of X-irradiation.

ISSN:0030-2414    

DOI:10.1159/000224518

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Irradiation of Ehrlich mouse ascites carcinoma cells by shock pulses produced by chemical explosions resulted in extensive killing as determined by a combination of both microscopically examined staining reactions and inoculations of the treated cells into mice. The pressure developed in the shock pulse is estimated to be of the order of one million pounds per square inch with a pulse time of the order of one microsecond. Total shock energies ranged from 1 calorie to a maximum of 40 calories. Cells showed considerable blebbing and internal deformities as a result of the initial mechanical effects of the shock wave, followed by induced biochemical changes. The explosive shock procedure described for cancer cells is adaptable to the killing of living cells generally.

ISSN:0030-2414    

DOI:10.1159/000224519

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

After presenting the clinical history of two young patients having retroperitoneal neoplasms of the seminoma type, we have discussed the general problem of partial or complete spontaneous regression of malignant tumours. On the basis of clinical and histological elements, and following a compilation of the literature, we have arrived at the conclusion that these neoplasms were in all probability retroperitoneal metastases of testicular seminomas having undergone complete spontaneous involution.

ISSN:0030-2414    

DOI:10.1159/000224520

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

2,3-Dihydroxypropanal is a minor component of normal carbohydrate metabolism; apparently both isomers of the racemic compound (D, L-glyceraldehyde) are metabolized in liver. In mice, single doses of 0.4 g/kg dihydroxypropanal reduced both sarcoma and carcinoma growth by more than 90%. Single doses also increases longevity of mice with L-1210 and P-388 leukemias by +48–60%. The responses of these two murine cancers in vivo appear similar to drug responses of human cancers. Mice of both sexes demonstrated no significant inhibition of blood-forming elements in femoral marrow following 1.5 g/kg doses of dihydroxypropanal, a circumstance rarely observed with drugs which inhibit cancer. Single large doses of dihydroxypropanal failed to effect either significant fluctuations in quantities of circulating erythrocytes, eosinophils or lymphocytes (although they induced a slight transient elevation in circulating neutrophils) or in quantitites of marrow erythroblasts, erythrocytes, lymphocytes, neutrophils or myeloid precursor cells. Intraperitoneal doses of 1.5 g/kg dihydroxypropanal produced gut irritation, but elicited no signs of gross or microscopic pathology in cardiac, renal, adrenal, testicular, hepatic, pneumal or splenic tissues. In mice, dihydroxypropanal may preferentially inhibit cancer growth without concomitantly damaging many normal tissues usually sensitive to drugs which inhibit cancer growt

ISSN:0030-2414    

DOI:10.1159/000224521

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Evidence has been obtained for the formation of a new molecular species of the enzyme dihydrofolate reductase in an amethopterin-resistant strain of the mouse lymphocytic leukemia L4946. The evidence consists of a more rapid elution of the R enzyme on Sephadex G-100, a greater reactivity with the R antibody, a marked degree of activation by C1-, whereas, the S enzyme is not affected, and also activation of the R enzyme by low concentrations of PCMB.

ISSN:0030-2414    

DOI:10.1159/000224522

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Long-term survivals following metastasis from Ewing’s sarcoma of bone were reviewed in the literature and found to be exceedingly rare. The unusual case of a child presenting with Ewing’s sarcoma of the fibula and pulmonary metastasis with resurrence after successful control by combined use of chemotherapy, radiotherapy, and surgery but with 8-years survival after presentation of metastasis is repor

ISSN:0030-2414    

DOI:10.1159/000224523

出版商:S. Karger AG    

年代:1970

数据来源: Karger

ISSN:0030-2414    

DOI:10.1159/000224524

出版商:S. Karger AG    

年代:1970

数据来源: Karger