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21. |
Cytosolic Calcium Staircase in Cultured Myocardial Cells |
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Circulation Research,
Volume 61,
Issue 6,
1987,
Page 934-939
Hon-Chi Lee,
William Clusin,
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摘要:
To elucidate the mechanism of the tension staircase, chick embryonic myocardial cell aggregates were loaded with the fluorescent cytosolic calcium indicator, indo1. Fluctuations in indol fluorescence were compared with recordings of cell edge movement during spontaneous beating and during stimulation by intracellular current pulses. Indo1-loaded aggregates exhibit fluorescence transients during each transmembrane action potential. The rising phase of the transients is rapid, but the decaying phase is slow (several hundred msec) and is similar in time course to the pandiastolic relaxation seen in the optical recordings of cell edge movement. Acceleration of beat frequency by brief depolarizing current pulses produces an ascending staircase in both edge movement and systolic [Ca2+]1. There is a similar staircase in the diastolic [Ca2+]1, which is also reflected by diastolic cell edge movement. The existence of a diastolic [Ca2+]1staircase may provide new insight into the mechanism of the force-frequency relation in the heart.
ISSN:0009-7330
出版商:OVID
年代:1987
数据来源: OVID
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22. |
Letters to the Editor |
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Circulation Research,
Volume 61,
Issue 6,
1987,
Page 940-940
Robin Norris,
Michael Brown,
William Weintraub,
Richard Helfant,
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ISSN:0009-7330
出版商:OVID
年代:1987
数据来源: OVID
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23. |
NEWS From the American Heart Association |
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Circulation Research,
Volume 61,
Issue 6,
1987,
Page 941-941
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PDF (124KB)
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ISSN:0009-7330
出版商:OVID
年代:1987
数据来源: OVID
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24. |
Meeting Calender |
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Circulation Research,
Volume 61,
Issue 6,
1987,
Page 942-944
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PDF (140KB)
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ISSN:0009-7330
出版商:OVID
年代:1987
数据来源: OVID
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25. |
Volume Author Index |
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Circulation Research,
Volume 61,
Issue 6,
1987,
Page 947-949
&NA;,
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PDF (110KB)
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ISSN:0009-7330
出版商:OVID
年代:1987
数据来源: OVID
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26. |
Volume Subject Index |
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Circulation Research,
Volume 61,
Issue 6,
1987,
Page 950-964
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PDF (1011KB)
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ISSN:0009-7330
出版商:OVID
年代:1987
数据来源: OVID
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