摘要:

Efferent vagal stimulation in the anesthetized dog with constant ventricular rate caused either no change in coronary sinus outflow and cardiac work, or a decrease in coronary sinus outflow associated with a greater decrease in cardiac work. When the decreases were observed they could best be explained by a negative inotropic effect of vagal stimulation on ventricular muscle, rather than by a direct vasomotor effect of vagal stimulation on the coronary bed. Critical review of apparent divergent results previously reported regarding the effect of vagal stimulation on coronary flow reveals that they are not inconsistent with the above hypothesis.

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

摘要:

Repeatedly-bred rats of both sexes develop subintimal accumulations of acid mucopolysaccharides and fibroblastic proliferation followed by distortion and destruction of elastic lamellae. Fibrosis, endothelial hyperplasia, lipid deposition, calcification and atheromata are also observed. Changes in the elastic tissue occur independently, and later than the alterations of the ground substance and the fibroblasts. Calcification is found in more advanced lesions, showing an affinity for areas rich in mucopolysaccharides. Exogenous ACTH and unilateral nephrectomy augment early atherosclerotic changes associated with multiple breedings.

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

摘要:

There have been many conflicting reports concerning the relationships of lipid, acid mucopolysaccharides, and elastic changes in the early pathology of atherosclerosis. Various new histochemical methods have been applied to grossly normal and early lesions of aortas of 50 individuals ranging from fetuses to 40 years of age with a view to illuminating these problems. The following paper presents our results of these studies.

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID