ISSN:0009-7330    

出版商:OVID    

年代:1958

数据来源: OVID

摘要:

A new method for cardiovascular shunt detection is described using the indicator-dilution principle applied to blood conductivity changes produced by 5 per cent saline. It possesses these distinct advantages over the Evans blue technic: (1) an unlimited number of determinations can be made without an increasing blood dye background or bluish discoloration of the patient, (2) oximetric determination of blood oxygen saturation is not interferred with, and (3) a simple modification of the carrier amplifiers of commonly used recording systems supplies most of the necessary instrumentation.

ISSN:0009-7330    

出版商:OVID    

年代:1958

数据来源: OVID

摘要:

A variety of procedures were used to change hemodynamics acutely and thereby to produce changes in blood volume. Changes in plasma specific gravity showed no relation to those in aortic pressure or total peripheral resistance, but were related to central venous pressure. The simultaneous cell fraction tended to vary reciprocally with the plasma specific gravity, indicating a bulk transfer of either red cells or of plasma between the large blood vessels and peripheral beds.

ISSN:0009-7330    

出版商:OVID    

年代:1958

数据来源: OVID

摘要:

Sodium salicylate consistently produces a prompt increase in heart contractile force when injected in anesthetized dogs in doses of 100 mg./Kg. intravenously. The increase in force is about 30 per cent and declines to control levels in 15 to 20 min. This effect is not considered of important therapeutic significance. Total doses of about 400 mg./Kg. consistently produce marked hyperpyrexia which closely resembles that of dinitrophenol and applied external heat in its circulatory characteristics; conspicuous features are extreme tachycardia, depressed S-T segment, moderate increase in heart force, and aortic pulse contours which indicate reduced stroke volume and vasodilation.

ISSN:0009-7330    

出版商:OVID    

年代:1958

数据来源: OVID

摘要:

Pyridoxine administered parenterally was found to have no effect on serum cholesterol levels of rabbits fed a normal diet, nor did it inhibit the development of hypercholesterolemia and atherosclerosis in rabbits fed a cholesterol-rich diet.

ISSN:0009-7330    

出版商:OVID    

年代:1958

数据来源: OVID

摘要:

Hypervolemia was produced in dogs by infusion of matched whole blood or of red cells suspended in dextran. In the dogs which had received matched whole blood, bleeding with simultaneous volume replacement with dextran produced acute hypervolemic anemia. This was associated with increased cardiac output, whereas no increase of cardiac output was seen in the same animals with a comparable amount of hypervolemia without anemia. The results suggest that anemia rather than hypervolemia was the important factor in causing an increase of cardiac output in these experiments.

ISSN:0009-7330    

出版商:OVID    

年代:1958

数据来源: OVID

摘要:

Following pretreatment with cortisol and NaH2PO4, a brief period of neuromuscular stress regularly produces massive myocardial necroses in the rat. Pretreatment with desoxycorticosterone and the phosphate is less effective in this respect.

ISSN:0009-7330    

出版商:OVID    

年代:1958

数据来源: OVID

摘要:

In studies in which tissue concentrations of cholesterol and total lipids were determined in male and female rats fed a control diet containing fat, the effects of gonadectomy were much smaller than in animals fed a fat-free diet in which gonadectomy tended to reverse the sex differences observed in these lipid values. Other phases of lipid metabolism were shown to be sex-linked as well. Gonadectomy resulted in decreased synthesis of cholesterol in rat liver slices and changes in the fatty acid composition of cholesterol esters in the liver.

ISSN:0009-7330    

出版商:OVID    

年代:1958

数据来源: OVID

摘要:

This investigation was undertaken in view of the interest lately aroused in the association of plasma lipids with atherosclerosis. Observations on the antilipemic and anticoagulant activities in man of sodium polyethylene sulfonate, a new drug with heparin-like properties, are presented. Alteration of the serum lipoprotein patterns of these patients observed during the course of the drug administration is also described.

ISSN:0009-7330    

出版商:OVID    

年代:1958

数据来源: OVID

摘要:

After inhibition of spontaneous tone, the contraction of spirally cut strips of aorta in response to norepinephrine was studied quantitatively in normotensive rats and in 4 different types of hypertensive rats. In no instance did the aortas of hypertensive rats show hyper-responsiveness to norepinephrine. The majority of responses were entirely normal; in a few instances there was decreased responsiveness. In vivo studies which fail to consider the critical effect of an altered “base-line” state in hypertension may demonstrate “hyper-responsiveness” which is more apparent than real.

ISSN:0009-7330    

出版商:OVID    

年代:1958

数据来源: OVID