ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

摘要:

Fourteen dogs were subjected to temporary occlusion of the portal vein. Electrocardiographic changes suggestive of epicardial or transmural necrosis of the high lateral region of the left ventricle and of subendocardial ischemia, were found in 55 per cent of the dogs. These electrocardiographic changes were accompanied by a significant rise of plasma GOT. Myocardial sections showed areas of multifocal necrosis, extending from endocardium to epicardium, with predominance in the lateral and anterior wall and pillars of the left ventricle and interventricular septum.

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

摘要:

Hemodynamic data during bladder distention in 2 patients with cervical cord transaction are presented. Rise in pulmonary artery pressure and pulmonary resistance is shown to occur when pressure is increased.

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

摘要:

Aortas of chickens were incubated during 72 hours with 17α- or with 17β-estradiol and the alkaline phosphomonoesterase activity determined. Paired experiments demonstrated that both isomers are able to enhance the activity of the enzyme in vitro. The possible relation of these results with atherogenesis is discussed.

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

摘要:

The effect of:l-epinephrine, acetylcholine, histamine, aminophylline, and serotonin on Ihe pulmonary circulation and ventilation was studied in anesthetized dogs. The following observations were noted: Serotonin produced an increase in arterial oxygen saturation, the other drugs a decrease. Although reduced, the effect was not eliminated by controlling the volume of ventilation or by the inhalation of 25 or 30 percent oxygen. The administration of 100 percent oxygen eliminated the response in all dogs studied. The effect was not abolished by controlling blood flow in addition to ventilation. Changes in the over-all ventilation/perfusion ratio appeared of major importance. In addition, these drugs apparently produced local changes in ventilation/perfusion ratios (physiologic shunting) and/or in the degree of anatomic intrapulmonary shunting of blood.The effects of changes in pulmonary blood flow on peripheral arterial oxygen saturation were also investigated. With the volume of ventilation constant, the following was observed: Increasing pulmonary blood flow by whatever means decreased SaO2; decreasing blood flow resulted in an increase in SaO2.

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

摘要:

The factor analysis of electrocardiograms from 17 normal individuals indicates that over 95 per cent of all the electrocardiographic “information” is accounted for by 3 factors. In the entire series, all individual leads were more than 93 per cent accounted for by 3 factors. These results indicate that there are no significant voltages at the body surface in normal individuals which can be ascribed to more than 3 internal generators. While these results indicate a 3-function system, they do not indicate a dipolar system since a dipole is a special case of a more general 3-function system.

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

摘要:

Collagen and elastine of the aorta were estimated in normal chickens of both sexes in cockerels, gonadectomized or treated with estradiol, and in hens treated with testosterone.The results showed that collagen and elastine were significantly higher in males than in females. Gonadectomy in males decreased significantly the content of collagen and elastine, so that the values became similar to those observed in females. The treatment of males with estradiol lowered the collagen and elastine content to values similar to those observed in females and in gonadectomized males. The treatment of females with testosterone increased significantly the collagen and elastine content of the aorta to levels similar to those observed in males.

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

摘要:

In open-chest dogs, the peripheral circulation was carried on a heart-lung machine. The pulmonary artery was obstructed and the left atrium and the right ventricle were drained into the venous reservoir of the machine. A balloon in the bloodless left ventricle permitted its distention. Pressures were recorded in the left ventricle and the aortic arch or a femoral artery. After distention of the left ventricle, the left ventricular diastolic pressure rose, the systemic arterial pressure fell, and bradycardia occurred. Distention of the left ventricle also caused reflex dilation of systemic veins. These effects were reversible and were abolished by section of the vagi. They are attributed to receptors in the myocardium of the left ventricle. It is considered likely that these reflex effects of left ventricular distention contribute to the mechanism of cardiogenic shock.

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

摘要:

Renal hypertension was produced in 26 test rats and fell to normal levels when they received CCl4. Our data indicate that this is due to liver damage and not to general inanition. These changes are reversible, since cessation of CCl4injections led to blood pressure rise. Morphologically, only a moderate degree of fatty metamorphosis is necessary to cause the blood pressure to fall from hypertensive levels to normotension. The biochemical change involved variable changes in albumin and globulin.

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID

摘要:

During the course of an investigation into the treatment of metabolic acidosis arising from total body perfusion, it was noticed that the intra-arterial administration of concentrated alkalies resulted in a fall in arteriovenous pressure difference at constant flow. A similar decline in peripheral resistance could be produced by hypertonic sugar and salt solutions. This response was found to be independent of the central nervous system. The role of the vasodilatation in the complex vasomotor reaction to the rapid intravenous injection of hyperosmotic agents was then investigated in the intact and vagotomized dog. It was found that when concentrations of up to 1,500 mOsm./L. were used, the predominant response was a delayed hypotension consistent with peripheral vasodilatation. This reaction was complicated by preliminary pulmonary hypertension when solutions containing more than 2,000 mOsm./L. were administered. Twenty per cent NaCl produced such a severe initial phase that the animals frequently died from acute cor pulmonale. The site of obstruction to blood flow through the lungs was variable. Fifty percent glucose could incite pulmonary hypertension, but urea was anomalous in that it was never observed to produce pulmonary vascular effects. Studies in the isolated perfused lung indicated that, again with the exception of urea, all solutions with an osmolarity equal or greater than 5 per cent NaCl evoked pulmonary hypertension. The increase in pulmonary vascular resistance was transitory in spite of recirculation. No response could be elicited when red cells were absent from the perfusate even though, under these conditions, the lung was still sensitive to serotonin. Microscopic examination of the circulation through the brain, lung, mesentery and thigh of both cat and dog demonstrated that intravascular red-cell agglutination occurred after regional arterial injection of highly concentrated salt and sugar solutions. This alteration in the stability of the red-cell stream is considered to be responsible for the obstructive effects of hyperosmotic agents previously attributed to vasospasm.

ISSN:0009-7330    

出版商:OVID    

年代:1960

数据来源: OVID