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1. |
The Concept of Active State in Striated Muscle |
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Circulation Research,
Volume 38,
Issue 2,
1976,
Page 53-59
FRED JULIAN,
RICHARD MOSS,
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ISSN:0009-7330
出版商:OVID
年代:1976
数据来源: OVID
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2. |
Distribution of Myocardial Blood Flow in the Exercising Dog with Restricted Coronary Artery Inflow |
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Circulation Research,
Volume 38,
Issue 2,
1976,
Page 60-66
ROBERT BALL,
ROBERT BACHE,
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摘要:
The effect of a proximal coronary artery stenosis on transmural myocardial blood flow during exercise was studied in nine dogs with electromagnetic flowmeter probes and hydraulic occluders on the left circumflex coronary artery. Regional myocardial blood flow at rest and during treadmill exercise was estimated with radioactive microspheres 7–10 μm in diameter. Exercise studies were performed during unrestricted coronary artery inflow (control exercise) and during partial inflation of the occluder to a level which did not reduce flow at rest but which limited the increase in flow during exercise to 66 ± 6percent; (mild restriction) or 44 ± 3percent; (severe restriction) of the value during control exercise. Mean myocardial blood flow at rest was 0.94 ± 0.06 ml/min per g of myocardium and increased to 2.45 ± 0.15 ml/min per g during control exercise, with uniform distribution across the wall of the left ventricle. Flow to the subepicardial myocardium was significantly greater during exercise in the presence of a mild restriction than during control exercise, whereas flow to deeper layers of myocardium was progressively decreased below the control level. A similar pattern of redistribution of flow occurred during exercise in the presence of a severe restriction, but flow to all transmural layers was below that during mild restriction, resulting in more marked subendocardial underperfusion. Thus, exercise in the presence of stenosis resulted in transmural redistribution of myocardial blood flow with subendocardial underperfusion in proportion to the degree of restriction of coronary artery inflow.
ISSN:0009-7330
出版商:OVID
年代:1976
数据来源: OVID
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3. |
Inhibition of Prostaglandin E2SecretionFailure to Abolish Autoregulation in the Isolated Dog Kidney |
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Circulation Research,
Volume 38,
Issue 2,
1976,
Page 67-73
GEORGE KALOYANIDES,
ROBERT AHRENS,
JAMES SHEPHERD,
GERALD DIBONA,
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摘要:
We studied the role of renal prostaglandins in the regulation of glomerular filtration rate (GFR) and renal blood flow (RBF) in the isolated dog kidney. Indomethacin or meclofenamate, 2 mg/kg of body weight, suppressed renal prostaglandin E2(PGE2) secretion, measured by radioimmunoassay, to zero within 20 minutes; the effect persisted for the duration of the study. When renal arterial pressure (PRA) was maintained at 104 mm Hg both drugs caused a sharp decrease in sodium excretion and RBF with redistribution of flow from inner to outer cortex. GFR was well maintained. In a separate group of experiments we examined autoregulation of GFR and RBF over the pressure ranges of 150–100 and 150–75 mm Hg, respectively, after inhibition of PGE2secretion and under control conditions. ΔGFR/ΔPRA(ml/min per mm Hg) was 0.020 ± 0.017 in the indomethacin group, 0.152 ± 0.055 in the meclofenamate group, and 0.086 ± 0.017 in the control group. The change in GFR for the indomethacin group was significantly less than that for meclofenamate (P< 0.01) and control groups (P< 0.025); the latter two groups were not statistically different from each other (P> 0.1). There was no significant difference (P> 0.1) between the three groups with respect to ΔRBF/ΔPRA,which measured 0.288 ± 0.046, 0.370 ± 0.112, and 0.438 ± 0.123 ml/min per mm Hg in the indomethacin, meclofenamate and control groups, respectively. Renal vascular resistance changed to a similar degree in all groups as PRAwas lowered from 150 to 75 mm Hg. The observation that inhibition of prostaglandin synthesis promotes a redistribution of RBF from inner to outer cortex suggests that renal prostaglandins may participate in the regulation of medullary blood flow. However, since autoregulation of GFR and RBF remained intact despite inhibition of prostaglandin secretion, these data argue against a role for renal prostaglandins in regulating whole kidney GFR and RBF.
ISSN:0009-7330
出版商:OVID
年代:1976
数据来源: OVID
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4. |
Ventricular Elastic Modulus as a Function of Age in the Syrian Golden Hamster |
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Circulation Research,
Volume 38,
Issue 2,
1976,
Page 74-80
RICHARD KANE,
THOMAS MCMAHON,
RICHARD WAGNER,
WALTER ABELMANN,
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摘要:
Analysis of passive right and left ventricular pressure-volume curves for hearts of 72 Syrian golden hamsters studied in vitro showed increases in ventricular weight, volume, and compliance at mid-age. Both ventricles were filled by syringe pumps at a constant rate. Ventricular compliance (dV/dP) was determined by electronic differentiation of the intraventricular pressures and formation of the ratio (dV/dt)/(dP/dt) as a continuous function of intraventricular pressure between 0 and 30 mm Hg. By relating, with justification, the left ventricle to a thin-walled elastic sphere, ventricular elastic moduli,E, for different ages were compared at constant levels of myocardial wall stress, ó. The elastic modulusEproved to be a linear function of ó. The slope of theE-ó plot yielded a stiffness constant,K, for each age group. Body weight, heart weight, end-diastolic volume, anddV/dPall varied by more than 200percent; up and then down as a function of age, butKwas not a significant function of age. These results suggest that the aging heart does not normally undergo substantial alterations in passive properties that affect the muscle cells and fibers themselves, but rather that the observed changes in compliance are primarily attributable to alterations in ventricular size
ISSN:0009-7330
出版商:OVID
年代:1976
数据来源: OVID
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5. |
Effect of Vagal Stimulation on the Overflow of Norepinephrine into the Coronary Sinus during Cardiac Sympathetic Nerve Stimulation in the Dog |
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Circulation Research,
Volume 38,
Issue 2,
1976,
Page 81-85
MATTHEW LEVY,
BENJAMIN BLATTBERG,
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摘要:
In anesthetized dogs with the chest open, supramaximal stimulation of the left cardiac sympathetic nerves at 2 and 4 Hz produced an increase of 40-50percent; in ventricular contractile force (CF) and of 40-65percent; in coronary sinus blood flow. At these frequencies of stimulation, norepinephrine (NE) overflow into the coronary sinus was 29.8 ± 5.1 (SE) and 54.9 ± 13.2 ng/min, respectively. Concurrent, supramaximal vagal stimulation, at a frequency of 15 Hz, had no significant effect on coronary sinus blood flow, but caused a 25percent; reduction in CF and a 30percent; decrease in NE overflow. The changes in CF and NE overflow evoked by vagal stimulation were prevented by atropine. These results are consistent with the hypothesis that there are muscarinic receptors on the postganglionic sympathetic terminals in the walls of the ventricles. Acetylcholine released during vagal stimulation combines with these receptors, causes a reduction in the liberation of NE, and thereby attenuates the positive inotropic response.
ISSN:0009-7330
出版商:OVID
年代:1976
数据来源: OVID
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6. |
Triggered Activity in Cardiac Muscle Fibers of the Simian Mitral Valve |
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Circulation Research,
Volume 38,
Issue 2,
1976,
Page 85-98
ANDREW WIT,
PAUL CRANEFIELD,
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摘要:
The action potential of cardiac fibers in the anterior mitral valve leaflet of the monkey heart is followed by an after-hyperpolarization. The addition of catecholamines causes a delayed after-depolarization to follow the after-hyperpolarization. The amplitude of the after-depolarization increases as the stimulus cycle length is decreased, or after premature stimulation, and as a result can reach threshold to yield nondriven, sustained rhythmic activity which we term triggered activity. This sustained rhythmic activity can be terminated by a single, appropriately timed, premature stimulus. The amplitude of the action potentials of mitral valve fibers is increased by catecholamines; the amplitude and rate of depolarization are depressed by verapamil. The amplitude of the action potentials is little affected by tetrodotoxin (TTX) but the maximum rate of depolarization is reduced by TTX. The delayed after-depolarization induced by catecholamines is abolished by verapamil, as is triggered activity. These observations suggest that mitral valve fibers generate slow response action potentials, that triggerable sustained rhythmic activity may be a property of the slow response and that such activity may cause the types of cardiac arrhythmias that usually are attributed to reentry.
ISSN:0009-7330
出版商:OVID
年代:1976
数据来源: OVID
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7. |
Inhibition of Hypoxic Pulmonary Vasoconstriction by Calcium Antagonists in Isolated Rat Lungs |
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Circulation Research,
Volume 38,
Issue 2,
1976,
Page 99-104
IVAN MCMURTRY,
ALLAN DAVIDSON,
JOHN REEVES,
ROBERT GROVER,
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摘要:
The role of a transmembrane calcium influx in hypoxic pulmonary vasoconstriction was studied in isolated, blood perfused, rat lungs. We reasoned that, if the influx of extracellular calcium mediated the hypoxic mechanism, pressor responses to alveolar hypoxia (2.5percent; O2) would be susceptible to inhibition by the calcium antagonists verapamil (2 x 10−5to 2 x 10−1mM) and SKF 525 A (2.6 to 260 mM). Susceptibility of hypoxic pressor responses to inhibition by these calcium antagonists was contrasted to that of pressor responses elicited by the humoral vasoconstrictors angiotensin II (1 or 0.5 μ) and prostaglandin F2αto (10 μg). Since neither saralasin (0.5 μM), a competitive antagonist of angiotensin II, nor meclofenamate (6.8 μM), an inhibitor of prostaglandin synthesis, depressed hypoxic pressor responses, it was concluded that these humoral transmitters were not directly involved in the hypoxic mechanism, and therefore served as independent reference agonists. The order of susceptibility of pulmonary pressor responses to inhibition by verapamil was hypoxia > angiotensin II > prostaglandin F2α. SKF 525A also reduced pressor responses to hypoxia more readily than those to angiotensin II. The greater inhibition of hypoxic pulmonary vasoconstriction by both calcium antagonists suggested that the hypoxic mechanism was critically dependent on the transmembrane influx of extracellular calcium. Mediation of the hypoxic response by this type of excitation-contraction coupling is consistent with the idea that hypoxia has a direct depolarizing effect on the vascular smooth muscle. It also provides a unifying explanation for inhibition of the hypoxic mechanism by various agents that have depressant or stabilizing actions on membranes in addition to other pharmacological effects.
ISSN:0009-7330
出版商:OVID
年代:1976
数据来源: OVID
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8. |
Contrasting Effects of Hypoglycemia on Plasma Renin Activity and Cyclic Adenosine 3′, 5‐Monophosphate (Cyclic AMP) in Low Renin and Normal Renin Essential Hypertension |
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Circulation Research,
Volume 38,
Issue 2,
1976,
Page 105-108
STEPHEN LOWDER,
PAVEL HAMET,
GRANT LIDDLE,
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摘要:
Insulin-induced hypoglycemia previously has been shown to provoke a β-adrenergic response that normally results in an increase in plasma renin activity (PRA). In our study, hypoglycemia induced definite increases in PRA in a group of five patients with normal renin essential hypertension but failed to do so in a group of six patients with low renin essential hypertension. In both groups, plasma cyclic adenosine 3′,5′-monophosphate (cyclic AMP; cAMP) increased more than 2-fold during hypoglycemia, but the response in the low renin group was significantly less than that previously observed in normal subjects under the same conditions. Plasma cortisol increased to an equal extent in both groups of hypertensive patients during hypoglycemia. Infusion of the phosphodiesterase inhibitor, theophylline, resulted in definite increases of PRA in patients with normal renin hypertension but not in patients with low renin hypertension. Because changes in the level of plasma cAMP during hypoglycemia have been thought to reflect adrenal catecholamine release, our finding of a blunted increase in plasma cAMP during hypoglycemia in patients with low renin hypertension may suggest that there is a generalized alteration in adrenergic responsiveness in this condition.
ISSN:0009-7330
出版商:OVID
年代:1976
数据来源: OVID
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9. |
Circulating Catecholamine Levels in Human and Experimental Hypertension |
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Circulation Research,
Volume 38,
Issue 2,
1976,
Page 109-114
JACQUES DE CHAMPLAIN,
LISE FARLEY,
DANIEL COUSINEAU,
MARIE-REINE VAN AMERINGEN,
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摘要:
The radiometric enzymatic technique of Coyle and Henry (J. Neurochem. 21: 61-67, 1973) was adapted to the measurement of serum catecholamines. This technique requires less time than other enzymatic techniques and is sensitive to quantities as small as 25 pg. In normotensive subjects lying supine for 20 minutes serum catecholamine levels averaged 0.218 ng/ml, with no obvious sex or age difference. Under these standardized conditions, the circulating catecholamine levels for a given individual are highly reproducible on different days over a period of several months. In 22 patients with essential hypertension, circulating levels were significantly higher, with an average of 0.370 ng/ml. More than 50percent; of the hypertensive patients had values greater than the highest value measured in normotensives. Systolic blood pressure and heart rate were significantly higher in the hypertensive group with elevated levels of circulating catecholamines than in the hypertensive group with normal levels. In one model of experimental hypertension, produced in the rat by administration of deoxycorticosterone acetate (DOCA) and saline for 4–8 weeks, serum catecholamines were significantly elevated. These findings suggest that the sympathetic system may play an important role in maintaining an elevated blood pressure in experimental hypertension and in a significant proportion of patients with essential hypertension.
ISSN:0009-7330
出版商:OVID
年代:1976
数据来源: OVID
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10. |
The Effect of Procaine Amide on Components of Excitability in Long Mammalian Cardiac Purkinje Fibers |
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Circulation Research,
Volume 38,
Issue 2,
1976,
Page 115-122
MORTON ARNSDORF,
J. BIGGER,
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摘要:
The microelectrode technique of intracellular constant current application and intracellular transmembrane voltage recording was used to study the effects of procaine amide (PA) on cardiac excitability. We measured the effect of PA in a concentration equivalent to clinically effective antiarrhythmic plasma levels (5 μg/ml), on nonnormalized and normalized strength-duration and charge-duration curves, membrane characteristics, and cable properties in long sheep Purkinje fibers in normal Tyrode's solution with [K+]o= 4.0 mM. PA exerted a complex action and influenced passive resistance-capacitance (RC) and active generator properties by decreasing membrane conductance, primarily membrane sodium conductance. Whether PA increased or decreased excitability depended on the relative contribution of the drug-induced alterations in passive and active membrane properties. These findings may explain, in part, the conflicting results of studies on cardiac excitability in the whole animal, as well as the clinical observation that PA may exert both artiarrhythmic and arrhythmogenic effects. The primary mechanism by which PA modifies excitability would seem to differ considerably from that of the structurally similar local anesthetic agent lidocaine.
ISSN:0009-7330
出版商:OVID
年代:1976
数据来源: OVID
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