摘要:

AbstractThe major source of neurotensin in the gut is the ‘N’ cell and this is found in the highest density in the ileum. The ingestion of food, particularly fat, causes the biphasic release of neurotensin‐like immunoreactivity (NTLI) into the circulation. The early peak occurs sooner than expected if it is due to the presence of chyme in the ileum, suggesting that the early release of neurotensin is due to a more proximal concentration of N cells or that neurotensin is released from the ileum by a more proximal stimulus. This paper investigates the site(s) of neurotensin release by studying: three groups of patients with various resections of the small intestine and the fashioning of duodenostomies, jejunostomies and ileostomies; and the dog with chronic gastric, duodenal and ileal fistulae, and following ileal resection. The results indicate that the jejunum and ileum are critical in the release of neurotensin following fat stimulation and that the stomach and duodenum have no direct role. The stimulation of the jejunum by fat causes the early rise of plasma NTLI by releasing neurotensin from the ileum. If chyme is prevented from passing to the distal jejunum the magnitude of the early peak is diminished and the second, later, peak is abolished. The second peak of plasma NTLI is due to the direct luminal stimulation of the distal jejunum and ileum by the products of fat digestion. Ileal resection completely abolishes any release of plasma NTLI in response to fat. It was concluded that the source of neurotensin released by the ingestion of food is the ileum. The release of neurotensin from the distal gut is dependent upon a signal from the proximal to the distal gut. The identity of the signal is unknown, but it is either neural or humoral and previous studies suggest a cholinergic‐dependent

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1988.tb00221.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

AbstractAbdominal scintiscans performed after the injection of autologous phagocytes labelled with99mTc‐stannous colloid particles provide an accurate assessment of the extent of disease in active inflammatory bowel disease. To study the correlation between phagocyte accumulation and histological indices of the degree of inflammation within bowel wall, the distribution of radiolabel within five freshly resected specimens of ileum and one of colon was assessed in five patients with active Crohn's disease. Each patient was injected with autologous99mTc‐labelled phagocytes prior to surgery. Multiple tissue samples (blocks) were taken along the length of the fresh resected specimen of bowel. The radioactive count of each block was obtained and they were then studied independently by two histopathologists who graded 12 histological features according to predefined criteria. High counts correlated with ulceration and submucosal mononuclear aggregates (P<0.05). Very low counts were obtained in mesentery and non‐ulcerated bowel. This study confirms the selective accumulation of99mTc‐labelled phagocytes within areas of ulcerated bowel in patients with active Crohn's

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1988.tb00222.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1988.tb00223.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1988.tb00224.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY