摘要:

Association of anorectal varices with oesophageal varicesFULMINANT HEPATIC FILAURE IN PREGNANT WOMN IN PAKISTAN: ACUTE FATTY LIVER OR HEPATITIS E VIRUS INFECTION?PROGNOSIS IN FULMINANT HEPATITIS: MODEL FOR TRANSPLANTATION DEVELOPING COUNTRIES.A PREDICTIVE ROLE FOR COMPLEMENT IN END STAGE LIVER CIRRHOSISSTUDIES OF HEPATITIS C VIRUS GENOTYPES IN ANTI‐HCV POSITIVE PATIENTS IN SINGAPOREPREVALENCE AND NATURAL HISTORY OF SUBCLINICAL PORTOSYSTEMIC ENCEPHALOPATHY IN CIRRHOSISINHIBITION OF HEPATITIS B VIRAL GENE EXPRESSED BY ANTISENSE PHOSPHROTHIOATE OLIGONUCLEOTIDESHERBAL COMPOUND 861 INHIBITS COLLAGEN GENE EXPRESSION IN EXPERIMENTAL LIVER FIBROISISChanges in Prevalence of e Antigen‐minus Mutant Hepatitis B Virus during the Course of Chronic Hepatitis BCorrelation between serum and liver tissue HCV‐RNA levels in patients with chronic hepatitis CThe mechanism of antiproliferative effect of desferriroxamine on human hepatoma cell lineEVOLUTIONARY ANALYSIS OF THE HYPERVARIABLE REGION OF THE E2/NS1 GENE IN HEPATITIS C VIRUSCLINICAL AND EXPERIMENTAL STUDY OF CINOBUFOTALIN ANTI HEPATITIS B VIRUSEXPERIMENTAL PATHOLOGICAL RESEARCH ON INFECTION OF MACACA ASSEMENSIS WITH HUMAN HEPATITIS B VIRUSThe qualitative and quantitative detection of anti‐HAIMMUNOGENICITY AND SAFETY OF AN INACTIVATED HEPATITIS A VACCINE AMONG SINGAPOREANSMOLECULAR CHARACTERIZATION OF THE PUTATIVE STRUCTURAL PROTEIN ENCODING REGION OF THE HEPATITIS E VIRUSEPIDERMIOLOGICAL STUDY OF HEPATITIS E VIRUS INFECTION IN NORTH‐WEST AREA OF CHOLLABUK‐DO (PROVINCE), REPUBLIC OF KOREASEROPREVALENCE OF HEPATITIS E IN A HOSPITAL BASED POPULATION IN SINGAPOREAN EPIDEMIC OUTBREAK OF HEPATITIS C IN KOREA: A LONG‐TERM PROSPECTIVE FOLLOW‐UP STUDY AND EPIDEMIOLOGIC INVESTIGATIONACUTE VIRAL HEPATITIS IN MALAYSIATreatment of Child Acute Iceterohepatitis by Umbilical Therrapeutic Bell for Liver DiseasesETIOLOGY OF WATERBORNE OUTBREAKS OF HEPATITIS NON A, NON B IN MIDDLE ASIA REPUBLICS OF THE FORMER USSRVIRAL HEPATITIS IN GUANGXI ZHUANG AUTONOHOUS REGION, CHINASERO‐EPIDEHIOLOGY OF VIRAL HEPATITS IN GUANGXI AUTONOMOUS REGION, CHINAEPIDEMIOLOGIOC FEATURES OF HEPATITIS E AND IMMUNOGLOBULINOPROPHILAXIS OF THIS INFECTION AMONG PREGNANT WOMENTHE CHANGES OF SODIUM METABOLISM IN CIRRHOSISMolecular analysis of the gene defects of ALA dehydratase deficiency porpharia developed in an elderly patientCYTOPROTECTIVE EFFECTS OF 3,3′,5‐TRIJODOTHYROINE (T2) FOR LOW t2 SYNDROME–FROM THE EXPERIMENT USING RAT CULTURES HEPATOCYTETHE CIRCADIAN RHYTHM OF CHOLESTEROL AND BILE ACID BIOSYNTHESISCHANGES IN NUCLEOTIDE DETERMINANTS OF THE ‘A’ DOMAIN IN PATIENTS WITH HBsAg POSITIVE HEPATOCELLULAR CARCINOMAThe therapeutic effect of Gliocladium in the treatment of experimental hepatic fibrosisALPHA‐FETO PROTEIN: A MARKER OF CELL PROLIFERATION AND DIFFERENTIATION IN HUMAN FETAL HEPATOCYTES.MICROENCAPSULATION OF HEPATOCYTES: A METHOD OF PROVIDING LONGEIVITY TO THE HEPATOCYTESSerum tissue inhibitor of metalloproteinases in patients with chronic liver disease and with hepatocellular carcinomaSECRETORY IMMUNOGLOBULIN A IN MALIGNANT OBSTRUCTIVE JAUNDICEAUTOIMMUNE LIVER DIEASE AND HEPATITIS CSIGNIFICANCE OF ACTIVATED T CELL SUBSETS (POSITIVE FOR HLADR AND HLADQ) IN PERIPHERAL BLOOD OF PATIENTS WITH AUTOIMMUNE HEPATITIS ‐ IN SPECIAL CONPARISON WITH C TYPE CHRONIC ACTIVE HEPATITIS‐INCREASED EXPRESSION OF LMP1 AND BCL‐2 GENES IN PRIMARY BILLARY CIRRHOSIS PATIENTSDETECTION OF A SOLUBLE FORM OF ADHESION MOLECULES (sICAM‐1, sVCAM‐1, aE‐SELECTIN) AND THEIR FUNCTION IN THE SERUM OF LIVER DISEASEBRANCHED CHAIN AMINO ACID (BCAA) IN PORTOSYSTEMIC ENCEPHALOPATHYSONOGRAPHIC IMAGING OF HEMODYNAMICS WITHIN VARIOUS HEPATIC TUMORSIMMUNOHISTOCHEMICAL SIGNIFICANCE OF THE MONOCLONAL ANTIBODY KI‐67 (MIB 1) IN HEPATOCELLULAR CARCINOMATHE EFFECTS OF NIFEDIPINE ON PORTAL HEMODYNAMICS IN PATIENTS WITH CIRRHOSISEFFECT OF BATHING IN HOT WATER ON PORTAL HEMODYNAMICS IN HEALTHY HUMANS AND IN PATIENTS WITH COMPENSATED LIVER CIRRHOSISSIGNIFICANCE OF SERUM FASTING TOTAL BILE ACID MEASUREMENT FORPROSPECTIVE PROGNOSTIC EVALUATIONCLOSE TEMPORAL RELATIONSHIP BETWEEN THE SUGAR CHAIN ALTERATION OF ALPHA‐FETOPROTEIN AND THE EVOLUATION OF HEPATOCELLULAR CARCINOMADETECTION OF HEPATITIS B VIRUS DNA BY POLYMERASE CHAIN REACTION IN PATIENTS WITH ISOLATED PRESENCE OF ANTIBODY TO HBV CORE ANTIGENTHE DISAPPEARANCE OF SERUM HBV DNA BY PCR ANALYSIS FOLLOWING HBeAg/anti‐HBe SEROCONVERSION IN CHRONIC HEPATITIS B IS A POOR PREDICTOR OF SUSTAAINED REMISSIONLOW‐DOSE INTERFERON ALFA 2B FOR CHRONIC HEPATITIS B IN MALAYSIAN PATIENTSTHE IMMUNE RESPONSE TO SIMULTANEOUS ADHINISTRATION OF HEPATITIS B VACCINE WITH HEASLES VACCINELONG‐TERM RESPONSE TO INTERFERON THERAPY IN HEPATITIS B VIRUS (HBV) PRE‐C MUTANTS ASSOCIATED CHRONIC HEPATITISVACCINATION AGAINST HEPATITIS B IN LONG AN COUNTRY, A HYPERENDENIC AREA OF PRIMARY LIVER CANCERTHE PREVALENCE OF SEROTYPE OF HCV FROM SERA OF CHRONIC LIVER DISEASES PATIENTS WITH ANTI‐HCV POSITIVE IN KOREAANALYSIS OF HEPATITIS C (HCV) TYPE SPECIFIC EPITOPES AND ITS RELATIONSHIP AND PREVALENCE IN DIFFERENT POPULATIONS OFBIOCHEMICAL, VIROLOGICAL AND HISTOLOGICAL EFFECTS OF A LONG‐TERM TREATMENT (12 MONTHS) WITH INTERFERON IN CHRONIC HEPATITIS CHUMAN LEUKOCYTE ALPHA INTERFERON IN THE TREATMENT OF CHRONIC HEPATITIS CHEPATITIS C RNA (HCV‐RNA) PREDICT RESPONSE TO THERAPY OF INTERFERON (IFN) IN PATIENTS OF CHRONIC HEPATITIS C (CH C)IgM ANTIBODY TO HEPATITIS C VIRUS IN POST‐TRANSFUSION HEPATITISCOMPARISON OF OCTREOTIDE, VASOPRESSIN AND SB TUBE FOR ACUTE BLEEDING OF ESO‐PHAGEAL VARICES. A PROSPECTIVE RANDOMIZED TRIALTHE EFFECT OF PROPRANOLOL ON GASTRIC MUCOSAL BLOOD FLOW AND PORTAL HYPERTENSIVE GASTROPATHY IN PATIENTS WITH LIVER CIRRHOSIS: A PRELIMINARY REPORTPRE SCLEROTHERAPY TREATMENT WITH SOMATOSTATIN IN BLEEDING OESOPHAGEAL VARICESTHE SAFETY OF ENDEOSCOPIC VARICEAL LIGATION (EVL) FOR ESOPHAGEAL VARIX ON THE ASPECT OF LOWER ESOPHAGEAL MOTOR FUNCTIONTHE EFFICACY OF ENDOSCOPIC VARICEAL LIGATION TREATMENT IN ESOPHAGEAL VARIX BLEEDINGELECTROCOAGULATION FOR BLEEDING VARICES IN CIRRHOSIS WITH PORTAL HYPERTENSION:LIVER TRANSPLANTATION FOR LIVER BASED METABOLIC DISORDERSLIVER TRANSPLANTATION FOR HEPATOCELLULAR CARCINOMAESTROGEN RECEPTORS IN GALLBLADDER CANCER ‐ A CLINICOPATHOLOGICAL STUDYTHE CRITICAL PORTA HEPATIS IN BILE DUCT DEVELOPMENT ‐ A CLUE TO BILIARY ATRESIA?THE ROLE OF TGF‐β1 IN THE DEVELOPMENT OF THE HUMAN BILIARY SYSTEMENDOSCOPIC CYANOACRYLATE INJUCTION FOR GASTRIC VARICEAL HAEMORRHAGETHE OPTIMAL TIMING FOR EXCHANGE OF BILIARY PLASTIC STENTS P. H. DANG. THE SPECIALISTS CENTRE, PENANG, MALAYSIAEMIDOSCOPIC MANAGEMENT OF MALIGNANT BILIARY STRICTURE ‐ RAFH EXPERIENCE AND REVIEW OF LITERATUREENDOSCOPIC MANAGEMENT OF DIFFICULT COMMON BILE DUCT STONESTHE BILE DUCT INJURIES—FOURTY CASES REPORTMONITORING OF LIVER AND SPLEEN ADJOSTMENT BY CT‐SCAN VOLUMETRY (CT‐V) IN PATIENTS UNDERGOING LIVER TRANSPLANTATION (OLT)HEPATITIS C IN PENANG, MALASIA P. H. DING THE SPECIALISTS CENTRE, PENANGComparison of serological anti‐HCV confirmation testsEXPRESSION OF HCV ENVELOPE PROTEINS IN MAMMALIAN CELLS AND EVALUATION OF THEIR UTILITY IN DIAGNOSIS OF VIRUS INFECTIONHCV SERP[REVA;EMCE OM; OVER DISEASE IN BANGLADESHTREATMENT OF CHRONIC HEPATITIS C WITH LOW‐DOSE INTERFERON ALFA‐2B P. H. Ding The Specialists Centre, Penang, MalaysiaHEPATITIS C INFECTION IN EGYPTIAN FAMILIESDETECTION OF HEPATITIS C VIRUS IN LIVER TISSUE BY IN SITU HYBRIDIZATIONCLINICAL SIGNIFICANCE OF NON ORGAN SPECIFIC AUTOANTIBODIES IN PATIENTS WITH CHRONIC VIRAL HEPATITIS CPREVALENCE OF ANTIBODIES TO HEPATITIS C VIRUS IN DIFFERENT POPULATION IN GUANGXI PROVINCE, CHINAA PROSPECTIVE LOOK AT HEPATITIS C. VIRUS INFECTION IN ACUTE&CHRONIC LIVER DISEASES AND IN BLOOD DONORS&RECIPIENTS IN A NORTH INDIAN HOSPITALOF REACTION OF DELAY TYPE IV HYPERSENSITIVITY IN PATIENTS WITH HEPATITIS CPREVALENCE OF BRAKTHROUGH IN CHRONIC HEPATITIS C DURING ALPHA INTERFERON THERAPYSUBSTITUTION RATE IN PRECORE/CORE GENE OF HEPATITIS B VIRUS IN ASYMPTOMATIC CARRIERSTREATMENT OF HEPATITIS B SURFACE ANTIGEN CARRIER IN THE EARLY STAGE OF THE INFECTION USING RECOMBINANT ALPHA INTERFEROTERFERON IN THE TREATMENT OF CHRONIC HEPATITIS B VIRUS INFECTIONINTERFERON THERAPY OF CHRONIC VIRAL HEPATITIS B ‐ INDIAN EXPERIENCETREATMENT OF CHRONIC HEPATITIS B WITH PREDNISOLONE WITHDRAWAL FOLLOWED BY INTERFERON ALFA‐2AABSTRACTTreatment of acute hepatitis C with natural alpha interferonAMINO ACID SEQUENCE SUBSTITUTION IN THE HYPERVARLABLE REGION OF HEPATITIS C VIRUS AND EFFECT OF INTERFERON IN PATIENTS WITH CHRONIC HEPATITIS CTHE CLINICAL SIGNIFICANCE OF HCV ANTIBODY POSITIVE INDIVIDUALS WITH NORMAL LIVER FUNCTIONRECOMBINANT INTERFERON ALFA THERAPY FOR CHRONIC HEPATITIS CDOUBLE BLIND RANDOMIZED TRIAL OF PARK‐20, AN AYURVEDIC DURG, IN ACUTE VIRAL HEPATITISTHERAPY OF INTERFERON ALPHA‐1 FOR THE CHRONIC HEPATITS B AND CClinical and histologic characterstics of non‐B, non‐C chronic hepatitis in KoreaTHE PREVALENCE OF HEPATITIS B AND C SEROMARKERS ON PATIENT WITH CHRONIC LIVER DISEASESHIGH DOSAGE INTERFERON THERAPY IN HEPATITIS B DNA NEGATIVE PATIENTSHIGH INCIDENCE OF VIRAL HEPATITIS B AND C INFECTION IN LYMPHOMA PATIENTS IN HONG KONGFULMINANT HEPATITIS IN CHILDREN ‐ THE ROLE OF PREVENTIONFULMINANT HEPATIC FAILURE CLINICAL PROFILE AND OUTCOMEAETIOLOGY OF SUBACUTE HEPATIC FAILURE IN INDIAETIOLOGY AND OUTCOME OF HEPATIC ENCEPHALOPATHY IN A LARGE REFERRAL CENTER IN INDIAAn autopsy analysis on 44 patients with severe confluent hepatic necrosisPRELIMINARY EVALUATION OF HGF FOR TREATMENT OF 248 CASES OF FULMINANT HEPATITISHEPATITIS B (HBV) MUTATIONS AND VARIANTS OCCURRING DURING PERINTAL HB IMMUNISATIONPROTECTION OF AN INFANT BY HBIG AND HB VACCINE FROM MOTHER WITH A FATAL HEPATITIS B PRECORE MUTATIONHBV vaccination in indonesian neonates: a five year follow‐upHEPATITIS B AND C VIRUSES INFECTION IN PATIENTS WITH HEPATOCELLULAR CARCINOMA IN GUANGXI REGION, CHINAINFLUENCE OF LOW IRON DIET ON THE EFFICACY OF INTERFERON THERAPY IN PATIENTS WITH CHRONIC LIVER DISEASE ‐ A PRELIMINARY REPORTNEW DEVELOPMENT IN THE MANAGEMENT OF LIVER AND BILIARY HYDATID INFECTIONSCHISTOSONAL LIVER DISEASE PRESENTATION, DIAGNOSIS ND MANAGEMENTDIFFERENTIAL EXPRESSION OF TRANSFORMING GROWTH FACTOR α (TGF α) AND INSULIN‐LIKE GROWTH FACTOR II(IGF II) IN CHRONIC HEPATITIS B. LIVER CIRRHOSIS, AND HEPATOCELLULAR CARCINOMANERVE TERMINALS CHANGE THE DISTRIBUTION IN THE LIVER WITH THE DEVELOPMENT OF LIVER DISEASEBEHAVIOUR OF HYALURONATE IN VARIOUS LIVER DISEASESLIVER ABSCESS. A CLINICAL STUDYSEQUENTIAL MEDICAL TREATMENT WITH NEEDLE ASPIRATION ON LARGE AMEBIC LIVER ABSCESS: IS IT ADVANTAGEOUS?MECHANISM OF TISSUE INJURY THROUGH OXIDATIVE AND NONOXIDATIVE PATHWAYS IN HUMAN AND EXPERIMENTAL HEPATIC AMOEBASISHEPATACYTE DAMAGE BY KUPFFER CELLS AND IMMIGRANT MACROPHAGES IN EXPERIMENTAL VISCERAL LEISHMANIASISTHE ERYTHROCYTES PHARMAKOCYTES IN THE TREATMENT OF PATIENTS WITH INFLAMMATORY DISEASES OF THE LIVER AND BILIARY SYSTEMCOLONIC INVOLVEMENT IN PATIENTS WITH AMOEBIC LIVER ABSCESSDOES AN ELEVATED CARBOHYDRATE‐DEFICIENT TRANSFERRIN LEVEL IN SERIUM REFLECT HEAVY ALCOHOL INGESTION IN THE PRESENCE OF ACTIVE LIVER DISEASE?DOPPLER ANALYSIS OF HEPATOCELLULAR CARCINOMATREATMENT OF HEPATOCELLULAR CARCINGMA (HCC) WITH BILE DUCT THROMBITHE APPLICATION OF THE PREDICTIVE VALUE MODEL TO SERUM ALPHA‐FETOPROTEIN IN HEPATOCELLULAR CARCINOMAPERCUTANEUS ETHANOL INJECTION THERAPY FOR HEPATOCELLULAR CARCINOMA SURVIVAL AND LOCAL RECURRENCECharacteristics of Early Hepatocellular CarcinomaHEPATITIS VIRUS INFECTION IN THE PATIENTS WITH HEPATOCELLULAR CARCINOMA IN JAPANTHE ROLE OF HABITUAL ALCOHOL DRINKING IN THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA IN JAPANESE PATIENTS WITH LIVER CIRRHOSIS‐ASSOCIATED HEPATITIS‐C VIRUSRisk for Hepatocellular Carcinoma in Patients with Liver Cirrhosisp53 changes in Hepatocellular Carcinoma (HCC) in Hong Kong ChineseHEPATITIS C VIRUS AN PRIMARY LIVER CANCER IN A HYPERENDEMIC REA OF LIVER CANCERTRANS ARTERIAL CHEMOEMBOLIZATION (TAE) BEFORE LIVER TRANSPLANTATION (OLT) FOR HEPATOCELLUYLAR CARCINOMA (HCC) IN CIRRHOSISTHERAPY: THERAPEUTIC STRATEGIES OF LIVER METASTASIS OF COLORECTAL CARCINOMATHE IMMUNOGENICITY OF HEPACCINE B: STUDIES IN INDONEDIAIMMUNIZATION AGAINST HBV IN THE PHILIPPINESINTERVENTION STRATEGY FOR HEPATITIS B VIRUS INFECTION WITH HBsAg IMMUNIZATION IN KOREAEFFICACY OF HEPATITIS B IMMUNIZATION PROGRAM IN THE REDUCTION OF HBV CARRIER RATE IN MALAYSIAHEPATITIS B VACCINE DELIVERY WITHIN THE EXPANDED PROGRAM OF IMMUN

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01710.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractA nested polymerase chain reaction was used to assess viraemia in blood transfusion recipients with no serological evidence of hepatitis C virus (HCV) infection (naive recipients) and in recipients with prior or existing HCV infection (infected recipients), who were transfused with HCV‐positive blood. In 10 hepatitis cases in naive recipients, defined as primary infection, nine showed clinical hepatitis, and one was sub‐clinical; the time between transfusion and elevation of alanine aminotransferase (ALT) levels was 15–60 days (37.9 ± 13.9). All 10 naive recipients showed abnormal ALT, and 10/10 and 7/10 were persistently positive for anti‐HCV and HCV‐RNA, respectively, for more than 1 year. Similarly, in five cases in previously infected recipients, defined as re‐infection, 4/5 showed clinical hepatitis, the time to elevation of ALT was 30–46 days (34.8 ± 6.4), and 5/5 and 3/5 were persistently positive for anti‐HCV and HCV‐RNA, respectively, for more than 1 year. All five infected recipients showed abnormal ALT. In conclusion, there was no significant difference(P= 0.05) in the frequency of the markers of infection resulting from primary or re‐infection with HCV, suggesting that primary infection fails to induce a prote

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01711.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractThe clinical utility of a new JCC‐2 enzyme‐linked immunosorbent assay kit that detects and quantitates anti‐hepatitis C virus (anti‐HCV) core antibodies (anti‐HCc) was investigated. Serum samples were obtained from 102 patients with various non‐A, non‐B liver diseases, including 19 cases of chronic hepatitis type C who had been treated with interferon (IFN). The results of the anti‐JCC‐2 assay were significantly correlated with serum HCV‐RNA positivity. Patients who were HCV‐RNA positive exhibited a high rate of positivity for anti‐JCC‐2 (72.2% in acute hepatitis,>90% in chronic liver diseases). The geometric mean of the anti‐JCC‐2 titre was not significantly different among different stages of chronic liver disease (among CPH, CAH and LC). The anti‐JCC‐2 titre decreased gradually in cases that became HCV‐RNA negative after IFN therapy. If HCV‐RNA positivity recurred, the anti‐JCC‐2 titre increased, indicating that serial measurements of the anti‐JCC‐2 titre are useful for monitoring the antiviral effect of IFN treatment. These results suggest that quantification of anti‐HCc by the anti‐JCC‐2 assay is superior to the semi‐quantification of circulating HCV‐RNA provided by monitoring of IFN therapy. Monitoring of HCV‐RNA status using reverse transcription‐nested polymerase chain reaction (RT‐nested PCR) is possible, but it is tec

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01712.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractThe formation of cholesterol monohydrate crystal initiates cholesterol gallstone formation. The nucleation time (NT), a light microscopy method, is used currently to estimate human bile metastability. Recently, a cholesterol crystal growth (CCG) assay utilizing photometric turbidity to quantitate cholesterol crystallization was developed using model bile systems. The object of this study was to determine whether this novel CCG assay was applicable to the quantitative assessment of native human bile metastability. Human gall‐bladder bile samples were collected from patients undergoing cholecystectomy. There were five patients with cholesterol gallstone and five stone‐free patients. A significant correlation between the onset time measured by the CCG assay and the NT observed by light microscopy was found in our modified assay condition where interference by bilirubin was negligible(P<0.01). Also, the growth rate measured by the CCG assay significantly correlated with the NT (P<0.05). These results indicate that the CCG assay is applicable to quantitative assessment of human bile metastability reflected by cholesterol crystal nucleation and that the cholesterol crystal growth is also conveniently estimated by this met

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01713.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractThis study evaluates the immune response of 20 haemodialysis (HD) patients vaccinated with hepatitis A (HA) vaccine and eight patients vaccinated with hepatitis B (HB) vaccine. Twenty patients and 22 healthy adults were immunized three times (months 0, 1 and 6) intramuscularly with a 0.5 μg dose. All members of both groups were positive for the antibody to hepatitis A virus (anti‐HAV) after three vaccinations. The geometric mean titres at 7 months were similar in both groups. No serious side effects were observed. Eight of the HD patients with HA vaccination were injected with yeast‐derived hepatitis B vaccine. The three doses of 10 μg were administered intramuscularly at 0, 1 and 6 months. The occurrence of antibody to hepatitis B surface antigen (anti‐HBs) was late in HD patients and the anti‐HBs level in HD patients was lower than that in healthy subjects. These results indicate that this HA vaccine has good immunogenicity compared with the HB vaccine and that the standard three doses of HA vaccine given at 0, 1 and 6 months are safe and effective even in HD

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01714.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractElectrocardiographic R–R interval variations were assessed to determine the functional integrity of the cardiac vagal nervous system in 20 normal controls and 71 cirrhotic patients. The ratio of the coefficient of variation to standard prediction value was used as an index. The cirrhotic patients showed significant reductions in the ratio of the coefficient compared with controls (0.71 ± 0.27vs0.91 ± 0.14;P<0.01). There was a significant relationship between decreased R–R interval variation and the liver function tests. The ratio of the coefficient increased with improvement in encephalopathy, and decreased with the development of encephalopathy.These results show that there is dysfunction of the cardiac vagal nervous system in patients with liver cirrhosis, and that this abnormality is partially reversible and might be related to liver dysfun

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01715.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractThe protective role of large spontaeous portosystemic shunts in oesophageal varices bleeding due to portal hypertension in liver cirrhosis is still debated. A series of 20 consecutive patients with haemodynamically efficient collaterals involving the para‐umbilical‐epigastric venous route (evaluated by Echo‐Doppler flowmetry) is reported. All patients presented absent or mild oesophageal varices at endoscopy. During a mean follow‐up period of 23.5 months, no patient developed large varices or experienced variceal bleeding. Hepatic encephalopathy was present in 35% of patients. Haemodynamically efficient spontaneous portosystemic shunts may protect cirrhotic patients from the risk of oesophageal varices forming and bleeding. The diversion of large amounts of blood from portal to systemic circulation correlates with the higher trend of hepatic encephalopathy in these p

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01716.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractThe dynamics of alanine aminotransferase (ALT), anti‐hepatitis C virus and hepatitis C virus (HCV) RNA in six cases with chronic HCV infection were studied for 3‐7 years. Two of the six cases showed continued elevation of ALT, and three showed intermittent elevation. All cases were persistently positive for anti‐HCV after initial seroconversion. Five of the six cases were persistently positive for HCV RNA detected by nested polymerase chain reaction, and one was positive intermittently. Thus hepatitis C virus replicates continually in a majority of patients with chronic hepatitis C, although some cases may show intermittent replication, and replication of hepatitis C virus does not always correlate with elevate

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01717.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractThe Nantong area is a high risk region for primary hepatocellular carcinoma (PHC) in the inshore area of the Yangtze River. However, no detailed data are available about hepatitis C virus (HCV) infection in this area. We examined the incidences of anti‐HCV and HCV‐RNA in blood donors with hepatitis B surface antigen (HBsAg)‐ and hepatitis B core antibody (HBcAb)‐negative and patients with chronic liver diseases in the Nantong area at Nantong Medical College, Jiangsu Province, the People's Republic of China. The incidences of HBV markers (HBsAg and/or HBcAb), anti‐HCV (C100‐3), second generation anti‐HCV, HCV‐RNA and any marker of HCV in the Nantong area were found to be: 0.0, 0.7, 0.4, 0.2 and 0.7% in donor bloods; 16.9, 0.0, 3.4, 15.7 and 16.9% in patients with acute hepatitis; 82.8, 2.7, 4.8, 7.5 and 10.2% in those with chronic hepatitis; 86.4, 4.5, 9.1, 4.5 and 11.4% in those with liver cirrhosis; 87.5, 6.3, 0.0, 0.0 and 6.3% in those with PHC; and 21.8, 1.3, 1.3, 0.0 and 1.3% in patients without liver diseases, respectively. Although the Nantong area is a high risk region for PHC, these data suggest that HCV infection is not an important aetiological factor for P

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01718.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractWe have previously established a model for micronodular cirrhosis by feeding Wistar rats alcohol, in the Lieber–DeCarli liquid diet, and exposing them to ‘low‐dose’ carbon tetrachloride (CCl4) vapour for 10 weeks. This study reports the spectrum of liver pathology seen in male Porton rats exposed to ‘low‐dose’ CCl4vapour 5 nights/week, 6 h/night while being fed alcohol (300 kcal/L) in the Lieber‐DeCarli diet. Micronodular cirrhosis developed in all animals after 5–7 weeks of treatment. The simultaneous administration of silymarin, a putative hepatoprotective agent, in the liquid diet, did not alleviate or prevent the chronic liver injury. The histopathological features of the liver injury are described, with particular emphasis on the presence of small epithelial cells (‘progenitor or stem cell'), which appear to be playing a role in

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01719.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY