摘要:

DETERMINATION OF PLASMA ENDOTOXIN LEVEL IN ACUTE HEPATIC FAILURE RATS AND ITS RELATIONSHIP WITH HEPATOCYTE GROWTH FACTOR Fuquing Yang.THE DIFFERENCE OF THE RESPONSIBILITY TO INTERFERON THERAPY ON CHRONIC HEPATITS INFECTED WITH HCV 1 OR HCV 2 Takeshi TANAKA, Satoshi TANAKA, Akira Hasegawa, Kenjiroh YAMAGUCHI Yohsuke Ohta, Michinori KOHARA, Nobu HATTORIEitablishment of Monoclonal Antibody Agrinet Hepatocyte Growth‐promoting Factor and Its Imunohistochemical Study Xirng‐ping KongLEISHMANIA DONOVAN1: DIFFEREKES IN FUNCTIONAL CAPABILITIES OF KUPFFER CELLS AND IMMIGRANT LLACROPHAGES IN A MURINE MODEL N K Ganguly, S. Kaushlva. N. Malla and R. C. MahaianCLINICAL EVALUATION OF SERUM INTERCELLULAR ADHESION MOLECULE LEVELS IN LIVER DISEASES Y. KOYAMA, M. IMOTO, Y. FUKUDA, I. NAKANO, F. URANO, N. KANDA, K ISOBE,&M. YAMADA, A. MARUI, Y. KATANO AND K. IMADAHEPATITIS C VIRUS GENOTYPES IN SINGAPORE AND INDONESIA. WC Ng. R Guan, BL Seef, HM Sjaifoellah Noer, L Lesmana, CM Ngiam, MF TanEFFECT OF INTERFERON TREATMENT ON PRE‐CORE HEPATITIS B: VIRUS (HBV) L. S. Liau, B. L. Seer, W. C. Ng and R. GuanHEPATITIS ‘C’ IN NON‐TRANSPUSION ASSOCIATED CHRONIC LIVER DISEASE IN PAKISTAN. H. A. Shah, K. Kayani, H. SheiXr. S. W. Jafri, S. Hazid, Z. Abbas, S. Abid. H. KhanDETECTION OF HBV DNA USING THE POLYMERASE CHAIN REACTION IN KOREAN PATIENTS WITH CHRONIC LIVER DISEASES Bc Yoo, JW Park and SM ParkLIVER TRANSPLANTATION IN HBsAg‐POSITIVE ADVANCED LIVER CIRRHOSIS IN KOREA Seung Keu Yoan, Naw Jong Baeg. Chang Don Lee, Doo Ho Park, 300 Sung Kia, Seong Taek Oh, Dong Ku Kim, In Chul KimHEPATITIS B IMMUNIZ. ATION OF INFASTS IN MALAYSIA Yamin A. MalikHEPATIC FIBROSIS IN RATS FED A LIQUID DIET WITH ETHANOL AND CARBONYL IRON T. Sohda, S. Kamimura, M. Takeshima, M. Iril and M. OkumuralMMUNOHlSTOCHEMICAL STUDIES OF PROLIFERATING HEPATOCYTES USIXG MONOCLONAL MB1 ANTIBODY (PARAFFIN Ki‐67) AKD PCNA ANTIBODY HEPATOCELLULAR CARCINOMA ASSOCIATED WITH AUTOIMblUNE HEPATITISCELL PROLIFERATION AND COLLAGEN FORMATION IN CULTURED FAT‐STORING CELLS (FSCs) FROM SECONDARY BILIARY FIBROSIS DISTRIBUTION OF ACTIVATED T LYMPHOCYTES. B LYMPHOCYTES ANDTHE RISK FACTOR FOR DEVELOPMENT OF THYROID DURING INTERFERON‐ALPHA THERAPY FOR CHRONIC HEPATITISC U Watanable, E. Hashimoro, M. Taniai, N. Ishiguro, T. Hisamitsu. N. HayashiTHE ROLE OF MITOCHONDRIAL ALDEHYDE DEHYDROGENASE(ALDH2) DEFICIENCY IN KOREANS WTH ALCOHOLIC LIVER DISEASE.CLINICAL AKD PATHOLOGICAL DIAGNOSIS OF COMMOW LIVER DISORDERSINDUCTlON OF UNSCHEDULED DNA SYhTHESIS BY METHYLEUCENOL AND IT'S 1′‐HYDROXY METABOLITE IN PRDIARY CULTURED RAT HEPATOCYTESIN VITROANDIN VIVOCOMPARISON OF E/NS1 REGION MINO ACIDS AND NUCI, EOTIDFS SEQUENCE OF HEPATITIS C VIRUS IN RESPONDENTS AND N0N‐RESPONDENTS TO, ALPHA‐INTERFERON TllERAPYTITRATION STUDIES OF JAPANESE PATIMT SERA WITH HEPATITIS C: DIFFERMCE BETWEEN IN VIVO INFECIIVITT AND IN VITRO TITER OF IICV‐ RNA M. Sugltanl. Y. Nakamura. M. Esuml. and T. ShlkataGENOTYPE OF HEPATITIS VIRUS IN OKINAWA ISLAND OF JAPANCURRENT SEROEPIDEMIOLOGICAL STATUS OF HEPATITIS A WITH A COMPARISON OF ANTlBODY TITER S. Fujiyama, K. Odoh. I. Kuramoto. K. Flizunob, R. Tsurusaki. T. SatoaCLINICAL SIUDY OF ICA CLASS ANTlBODY AGAINST HEPATITIS C VIRUS CORE ANTIGEN IN PATIENTS WITH TYPE C CHRONIC UVER DISEASE M. Tanaka. S. Sato. S. Fuiivama. S. Kawano. Y. Taura. H. Chikazawa. Y. Honda. I. Shibaa. T. SatoDetection and Sequencing of the pmcorclcorr gene of hepariiis B virus DNA from patients with ith so‐callcd hepatitis F M. Shimoiima. M. Morivama. Y. ArakawaUSE OF A SAFETY CATHETER AT REMOVAL OF THE T‐TUBE AFT5R ORTHOTOPIC LIVER TRANSPLANTATION (OLT) G. Colella, G. Cozzi, M. Bellomi, A. SeveriniEXTRAHEPATIC PORTAL‐SYSTEMIC SHUNT EMBOLZATION IN CIRRIIOTIC PATIENTS WITH CHRONIC RECCURENT HEPATIC ENCEPHALOPATHYINTRAHEPETIC BILIARY PAILLOMATOSIS Chang K. W., Robert P. Jalleh. Syed M. NooriBENIGN TUMOURS OF THE LIVER n* r INFANCY AND CHILDHOODHEPATITIS C IN RUSSIA AND OTHER REPUBLICS OF THE FORMER SOVIET UNIONEfficacy of Interferon(IFN) therapy to chronic hepatitis type CThe relationship between superoxidePREVENTIVE EFFECT GF GOMISIti A, A LIGXAN COMPONENT OF SHIZANDRA FRUITS, ON ACETMIKOPHEN‐ INDUCE0 HEPATOTOXICITY IN RATS. S. Yamada, Y. Murawaki&H. KawasakiTOLERANCE AND PHARUACOKINETICS Of THYUOSIN α1 IN MAN K Hino S Iino, T Irino, T earada, DH Van ThielROLE OF EICOSAPESTAEXOIC ACID IN LIPID METAROLISY IS THE LIVER ‐ WITH SPECIAL REFERENCE TO EXPERIMWTAL FATTY LIVERTRIAL OF MAKING HEPATIC FIBROSIS WITH BALB/C MICE BY VERY SMALL QUANTITY OFCARBON TETFIACHLORIDE ADMINISTRATION Y. Honda. S. Fujyama, K. Waki. T. SatoInfluence of bile on pancreatic secretion and plasma concentrations of regulatory peptidesENDOSCOPIC TRANSPAPILLARY GALLBLADDER DRAiNAGE IN PATIENTS WITH ACUTE CHOLECYSTITISHIGH PREVELANCE OF ANTIBODIES TO CENTROblERE AND CENP‐B IN PRIMARY BILIARY CIRRHOSIS: COMPARATIVE PROFILES OF JAPAhZSE ASD TAIWANESE PATIENTS S. Parveen, S. A. Morshed. M. Nishioka. H. S. Hone. and T. Hachiya.A CASE OF TRANSIENT GALACTOSEHIA IN NEONATAL PERIOD M I, Caccamo, P Bini, A Noseda. G PaganiEffect of Interferon alfa‐2a on Hepatitis‐C chronic liver disease. Anwaar A. Khan, Altaf AlapQUANTITATION OF HEPATITIS C VIRUS (HCV) ANTIBODIES (CORE, NS3 AND NS4 EPITOPES) IN PATIENTS WITH CHRONIC HEPATITIS C: CORRELATION WITH VIRAL GENOTYPE AND RESPONSE FOLLOWING α‐INTERFERON.HEPATITIS C VIRUS (HCV) GENOTYPES AND POST INTERFERON RESPONSE.Resistance of Chronic Active Hepatitis C to Interferon TheraphyControlled randomized trial of Lymphblastoid Interferon vs. Placebo in the treatment of chronic hepatitis B.The prevalence of human immune deficiency virus(HIV), hepatitis B virus(HBV) and hepatitis C virus(HCV) in patients indergoing sclerotherapy for esophageal variesPrevalence of hepatitis B and bepatitis C virus in Thailand.Estimation of body composition in children with liver disease by the bioelectrical imwdanceEFFECT OF PRE‐OPERATIVE TRANSCATHETER ARTERIAL EMBOLIZATlON FOR HEPATOCELLULAR CARCiNOMA M. Ishikawa, P. Quirk, R. W. ShepherdDETECTION OF HEPATITIS B VIRUS NUCLElC ACID SEQUENCES IN SERA USING AN IN‐ VITRO AMPLIFICATION ASSAYHEPATITIS B RELATE0 HEPATOCELLULAR CARCINOMA IN A MULTIRACIAL COMMUNITY: ASSOCIATED RISK FACTORSEVALUATION OF EFFECTIVENESS OF HEPATITIS B IMMUNIZATION B IMMUNIZATION IN NEWBORN INFANTS IN GUILIN, CHINAULTRASTURAL EVIDENCE FOR MITOCHONDRIAL INJURY AS THE PRIMARY LESION IN PALMYRAH‐INDUCED HEPATOTIXICITYTHE USEFULNESS OF THE DETERMINATION OF 7‐S COLLAGEN ANTIGEN IN THE TREATMENT OF INTERFERON K. Yonekura, S Hatakeyama, J. Ueki, M. Sugiyama, M. SekiyaINTRA DERMAL VACCINATION WITH ENGERIC B HUMORAL RESPOND 3 YEARS EVALUATION Harijono AchmadPRE‐OPERATIVE‐CHEMOTHERAPY IN ‘UNRESECTABLE’ HEPATOBLASTOMA Chang KW, Jessie A. De Bruyne, Yip CH, LinTREATMENT FOR CHRONIC HEPATITIS B WITH ACUTE EXACERBATION BY

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01248.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractThe epidemiology and mode of transmission ofHelicobacter pyloriis currently unclear; it is postulated that the human stomach is the natural reservoir and that spread occurs by faecal‐oral or oral‐oral transmission. The aim of this study was to assess the prevalence ofH. pyloriin gastroenterologists and gastroenterology nurses compared with internists, general nurses and the normal population. An enzyme‐linked immunosorbent assay technique (sensitivity 96%, specificity 88%) was used to detect circulatingH. pyloriimmunoglobulin G antibodies in 39 gastroenterologists, 107 gastroenterology nurses, 25 internists and 42 general nurses. These subjects were compared to an age‐ and sex‐matched Caucasian population obtained by random sampling of an urban population area. The overall prevalence ofH. pyloriin gastroenterologists was 69% compared to 40% of internists (P<0.01), 17% of gastroenterology nurses (P<0.001), 19% of general nurses (P<0.01) and 32% of controls (P<0.01). There was no significant difference inH. pyloriprevalence between the gastroenterology nurses and controls, general nurses and controls. The prevalence in gastroenterologists increased with years of practice to levels greater than age‐matched controls. The prevalence in gastroenterology nurses increased with age and years of working and was similar to age‐matched control subjects. These findings of an increased prevalence ofH. pyloriinfection in gastroenterologists performing endoscopy support human‐to‐human transmission possibly from patients

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01249.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractThe aim of this study was to develop a new cellular restoration model using primary cultured rabbit gastric mucosal cells, and to evaluate the role of cytoskeleton and calmodulin in this process. Confluent monolayer mucosal cell sheets consisting mainly of mucous cells were wounded, and a rotating silicon tip was used to make cell‐free areas of constant size. The process of restoration was monitored, and the cell‐free area was measured and analysed quantitatively.Artificial wounds recovered in 36 h in controls; however, mucosal cell repair was inhibited by treatment with the actin inhibitor, cytochalasin B, and the calmodulin inhibitor, W‐7. In the process of restoration, bromodeoxyuridine (BrdU)‐positive cells appeared around the wound 24 h after injury and then disappeared after the complete repair. Because BrdU‐positive cells were never detected within 24 h after wounding, initial recovery of the wound occurred only by cell migration. Both the migration and the proliferation stage are seen with this model. This culture model is suitable for the analysis of gastric mucosal restoration. Present data are consistent with the hypothesis that the integrity of the cytoskeletal system is important for restoration after damage of the gastr

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01250.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractIt has been reported recently that there was genetic heterogeneity in gastric ulcer disease depending upon the location of the ulcer, and that there was a significant association between the restriction fragment length polymorphism (RFLP) for pepsinogen C (PGC) gene and gastric body ulcer. In the present study, the association of the RFLP for PGC gene with combined gastric and duodenal ulcers was investigated to analyse genetic factors in its aetiology. Eighty unrelated controls and 47 patients with combined gastric and duodenal ulcers were studied. The allele frequencies of the large (3.6 kilobase EcoRI fragment) and the small fragment (3.5 kilobase EcoRI fragment) were, respectively 80.6 and 19.4% in controls, 60.0 and 40.0% in patients with combined gastric body and duodenal ulcers, 69.0 and 31.0% in patients with combined gastric angular and duodenal ulcers, and 81.8 and 18.2% in patients with combined gastric antral and duodenal ulcers. The allele frequency of the small fragment was significantly higher in patients with combined gastric body and duodenal ulcers than in controls. The genotypes that possessed the small fragment were significantly more frequent in patients with combined gastric body and duodenal ulcers (66.7%) than in controls (33.8%) and combined gastric antral and duodenal ulcers (27.3%). These results suggest that there is genetic heterogeneity in combined gastric and duodenal ulcers depending upon the location of gastric ulcer, and that combined gastric body and duodenal ulcers are associated with the small fragment allele of the PGC RFLP in the same way as solitary gastric body ulcers.

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01251.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractActivation of the proenzyme of urokinase (uPA) on the surface of cancer cells has been implicated in the initiation of focal proteolytic mechanisms that permit invasion and metastasis by colon cancers. The activity of uPA on the cell surface appears to be a function of the number of uPA‐specific receptors (uPAR) and the extent of inhibition of uPA by plasminogen activator inhibitors (PAI). The mapping of the genes coding for uPAR, and for PAI‐2, was performed to determine whether their chromosomal localization suggested their involvement in the genetic alterations associated with cancer cell DNA.This study confirms the localization of the human urokinase plasminogen activator receptor gene to chromosome 19q and, usingin situhybridization, provides a precise localization to chromosome 19q13.2. In addition, our results confirm the previous allocation of the human plasminogen activator inhibitor‐2 gene to a location 18q21.3 → 18q21.1, a location that corresponds to the commonest (>70%) somatic deletions found in colorectal carcinomas. The mapping of the uPAR and PAI‐2 genes enables the elucidation of their possible involvement in the genetic alterations that determine the invasive and metastatic phenotypes in colorect

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01252.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractTo investigate whether there are any differences between the clinicopathologic characteristics of early gastric cancer (EGC) patients in Eastern and Western countries, 208 Taiwanese patients with EGC were reviewed between 1964 and 1992. The incidence of cancer has increased slightly over the 29‐year period. Men were diagnosed with EGC frequently than women, and their mean age was 56 years. Epigastralgia (58.2%) was the most common symptom, whereas 5.8% of cancers were incidentally detected by endoscopy. Physical signs and laboratory tests were of limited value in making the diagnosis. Endoscopy was a better diagnostic aid than radiology. Tumours were frequently located in the lower third (53.2%) and middle third (43.3%) of the stomach. Cancers of the elevated type (17.8%) were less frequent than the depressed type (82.2%). Type IIc(31.2%) was the most common macroscopic type. The frequency of mucosal carcinoma (51.0%) was similar to submucosal carcinoma (49.0%). Mucosal carcinoma had less lymph node metastases (3.1%) than submucosal carcinoma (12.2%;P<0.05), with an overall frequency of metastases of 7.5% (14/186). The 5‐year survival rate was 90.8%. The clinicopathologic characteristics of EGC in Taiwan were similar to those of Western countries and other Eastern countries. Improvement of diagnostic examinations and endoscopic surveillance of asymptomatic subjects may lead to early diagnosis and thus ensure a more favourable outc

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01253.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractIn patients with parenchymal liver disease, glucuronidation of drugs is generally preserved but oxidation is impaired. This study explores the effects of liver injuries induced in rats by the administration of acute carbon tetrachloride, chronic bile duct ligation and chronic choline deficiency for 30 weeks on the glucuronidation ofp‐nitrophenol and 1‐naphthol, both before and after solubilization of the microsomes and compares this to three measures of oxidation. Cytochrome P450 content was reduced to 17% of control values after acute carbon tetrachloride and to 35% of control values after bile duct ligation. Cytochrome C reductase fell to 58 and 32% of control and aniline hydroxylase to 46 and 13%, respectively, after acute carbon tetrachloride and bile duct ligation.P‐nitrophenol glucuronidation by native microsomes was 206 and 73% of controls in the respective models, while 1‐naphthol glucuronidation was 167 and 66% of control. Latent uridine diphosphate‐glucuronosyltransferase (UDP‐GT) activity, that is, differences between solubilized and native activity, was decreased by each liver injury. Chronic choline deficiency had little effect on the oxidation and native glucurondation activity, although latent glucuronidation activity was lower. These studies suggest a preservation of glucuronidation compared to oxidation at the microsomal level in these experimental liver injuries. The data also support the hypothesis that a release of latent UDP‐GT activity may contribute to th

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01254.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractThe present study describes the plasma levels of soluble fibronectin (FN), C3d, the breakdown product of C3complement and Ba, the breakdown product of properdin factor B, in 30 patients of uncomplicated acute viral hepatitis (AVH), 64 patients of fulminant hepatic failure (FHF) and 29 patients of subacute hepatic failure (SAHF) with different hepatitis viral infectionse. Aetiological analysis of these patients demonstrated hepatitis B, hepatitis C and hepatitis non‐A, non‐B, non‐C (NANB‐NC) infections in 6.7, 13.3 and 80% cases, respectively, of the AVH group; 18.8, 42.2. and 39.0% cases, respectively, of the FHF group; and 31.0, 34.5 and 34.5% cases of the SAHF group. None of them had hepatitis A infection. The analysis of data showed that the plasma FN level was significantly reduced in patients with FHF and SAHF as compared to AVH patients and healthy persons. Fibronectin levels in AVH was comparable to that in the healthy group. Further, the FN level was not dependent on the nature of aetiological virus. The level of C3d in plasma was significantly high in all patients of FHF and SAHF, irrespective of their viral aetiology, compared to the AVH group and the healthy group. Like FN, the C3d level was comparable in the AVH and healthy groups. However, the Ba level was comparable to the normal value in all types of infections including the AVH, FHF and SAHF groups. These findings were used to explain the possible roles of fibronectin and complement in the immunopathogenesis of liver injury in patients of acute liver failure of viral ae

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01255.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractMass screening for liver cancer based mainly on abdominal ultrasound was begun in major cities of Hokkaido, Japan, in November 1981, to enable early detection and treatment of hepatocellular carcinoma (HCC). Serum alpha‐fetoprotein levels were also measured to minimize false negative studies. Examinees included those who sought liver disease screening as well as high risk individuals: hepatitis B surface antigen carriers and those with a past or current liver disease, history of blood transfusion, family history of liver cancer, and more recently those with positive anti‐hepatitis C antibodies. The examination was carried out on each Saturday and Sunday as one round, and by February 1992 48 rounds had been performed. A total of 8090 individuals were investigated, and HCC was detected in 91 with a detection rate of 1.12%. This rate was 1.6% among 5684 individuals who were selected for high risk. Cumulative rates of survival among these patients were 79.0% at 1 year, 43.8% at 3 years, 19.3% at 5 years and 15.4% at 7 years. These survival rates were comparable with those for the patients with HCC diagnosed during follow‐up of chronic liver disease and treated at our hospital. The cost for detecting one HCC patient in this programme was ¥ 2 660 000 (∼US$25 000), which was less than those for some other types of cancer in a similar setting. Considering the high detection rate in this programme, we feel that similar programmes should be encouraged and s

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01256.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

AbstractPsychotropic action of a branched‐chain‐enriched amino acid solution (Aminoleban) was quantitatively and visually examined in six cirrhotic patients with mild hepatic encephalopathy (grades I and II) using electrophysiological and psychometric methods. Neurophysiological effects of the amino acid solution were observed by comparing topographic spectrum analyses of electroencephalography (EEG) before and immediately after an intravenous 3 h infusion of the solution. The delta wave in the frontal region diminished from 61 ± 13 to 12 ± 4% (P<0.01) and the alpha wave in the occipital region increased from 11 ± 3 to 51 ± 11% (P<0.01). Latencies of the P3 wave in visual evoked potentials, which were topographically recorded in the occipital region, shortened from 220 ± 32 to 148 ± 19 ms (P<0.01). Latencies of the P300 wave in event‐related potentials, which were topographically recorded in the centro‐temporal region, shortened from 493 ± 81 to 360 ± 93 ms (P<0.05). Topographic reaction pattern of P300 was irregular toward the occipital or parietal region in cirrhotic patients. The EEG frequency power spectrum, illustrated by the colour density spectral array of computer‐aided polysomnography analysis, clearly showed a gradual increase of the alpha wave spectrum and a gradual decrease of the delta wave spectrum after initiation of the infusion. These immediate neurophysiological changes were confirmed by improvement of quantitative psychometric tests including number connection test, reaction time to sound, and digit symbol and block design tests of Wechsler Adult Intelligence Scale.From the results, it was concluded that branched‐chain amino acids functioned as psychotropic drug for cirrhotic patients with mild hep

ISSN:0815-9319    

DOI:10.1111/j.1440-1746.1994.tb01257.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY