摘要:

This study evaluates the presence of Langerhans’ cells and expression of L1 antigen in squamous epithelium of the normal and dysplastic transformation zone of the cervix uteri and determines the influence of tobacco smoking and pregnancy. Women who smoked and pregnant women showed a decrease of Langerhans’ cell counts in normal epithelium. In cervical intraepithelial neoplasia (CIN) 1 lesions, decreased Langerhans’ cell counts were noted. L1 antigen expression was significantly less in CIN of all grades. Normal squamous epithelium of smokers showed weaker staining for L1 antigen but total staining scores were not significantly different. These data suggest a decrease in epithelial cell-mediated immune response in smokers, pregnant women and in low-grade CIN. Dysplastic squamous cells probably have intracellular regulatory problems independent of other immune cells.

ISSN:0378-7346    

DOI:10.1159/000292270

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

A total of 109 patients submitted to surgery for the correction of urinary stress incontinence (USI) by two different techniques, i.e. anterior colporrhaphy (group I, n = 57) when cystocele grade II/III was present, and Burch procedure (group II, n = 52) when cystocele grade I was present, were reevaluated an average of 5 years after surgery (range: 54–66 months). The curve constructed with the reevaluation data showed a sharp superiority of the Burch technique in terms of correction of USI and associated genital prolapses. There was a progressive recurrence rate that stabilized at 5 years, with values of 78.9% in group I and 40% in group II. Anterior colporrhaphy was ineffective for the correction of any of these parameters in group I. The data clearly show the need to improve the presurgical diagnostic methods for the selection of patients that will benefit from treatment: detailed history of the current disease and auxiliary tests such as Q-tip test, transvaginal ultrasound, and urodynamic study. Other factors were associated with ineffective treatment in both groups, such as hypoestrogenism (20/109), excessive weight gain (19/109) and chronic intestinal constipation and/or coughing present in 36 patients, with recurrence in 28 of the

ISSN:0378-7346    

DOI:10.1159/000292271

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

We have previously described the identification of the human decidua-associated protein hDP200 as a rheumatoid factor [1], Assuming that rheumatoid factor binds to Fc of immunoglobulins, the existence of high-molecular-weight complexes was studie in decidual extract, pooled uterine fluid from proliferative and early secretory phase, menstrual fluid and amniotic fluid. High-molecular-weight complexes containing hDP200 and other immunoglobulins were found only in menstrual and amniotic fluids and not in decidual extract or uterine fluid. It is possible that complexing of the immunoglobulins by hDP200 serves as one of the mechanisms that ensure suppression of the immune response to fetal antigens.

ISSN:0378-7346    

DOI:10.1159/000292272

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

Late-onset 21-hydroxylase deficiency (21-OHD) is a congenital enzymatic defect in the glucocorticoid and mineralocorticoid steroidogenic pathways. The manifestations, including hirsutism and infertility, usually occur at puberty or young adulthood. In infertile, anovulatory women with late-onset 21-OHD, the usual therapy is glucocorticoids for ovulation induction. In this case, we report the sole use of clomiphene citrate to induce ovulation in a patient with late-onset 21-OHD. A hirsute and oligomenorrheic woman was diagnosed as having polycystic ovary syndrome at age 25. Her hirsutism responded to oral contraceptives. At age 31 she was given clomiphene citrate alone for ovulation induction and conceived in her fourth cycle. At age 36, because of increased hirsutism she was diagnosed with late-onset 21-OHD by an ACTH stimulation test. The induction of ovulation in late-onset 21-OHD patients has been with glucocorticoids. Given the success in inducing ovulation with clomiphene citrate alone in this patient with well-documented late-onset 21-OHD, it may be worthwhile to study the sole use of clomiphene citrate for ovulation induction in these patients.

ISSN:0378-7346    

DOI:10.1159/000292273

出版商:S. Karger AG    

年代:1996

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000291576

出版商:S. Karger AG    

年代:1915

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000291577

出版商:S. Karger AG    

年代:1915

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000291578

出版商:S. Karger AG    

年代:1915

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000291579

出版商:S. Karger AG    

年代:1915

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000291581

出版商:S. Karger AG    

年代:1915

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000291584

出版商:S. Karger AG    

年代:1915

数据来源: Karger