摘要:

The present study attempts to confirm the effectiveness of a new method of pelviscopic hysterectomy which maintains the pelvic floor integrity comparable to that in a supracervical uterus amputation. A major advantage of this procedure is that the central portion of the cervix and transformation zone is punched out using a special resection tool for the purpose of removing any potential source of cancer. Thirty-four specimens resected by pelviscopic hysterectomy were investigated using histological giant and serial sections. Morphometrical analysis was performed using MOP-AM02 (Kontron Instruments). The transitional zone and cervical glands were excised completely with an average security distance of 1.5 cm to the resection margins. No mesonephric remnants were found which might serve as a possible source of adenocarcinoma. Our study confirms that the application of this new technique of pelviscopic hysterectomy is not limited by the development of stump carcinoma while also possessing the additional advantage of maintaining pelvic floor integrity.

ISSN:0378-7346    

DOI:10.1159/000292538

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Monoclonal antibody Ki-67 identifies cells in Gl, S, G2, and M phases of the cell cycle. In this cytokinetic study, Ki-67 was used to characterize tumor cells in human cervical cancer specimen. This immunohistochemical study showed that Ki-67 staining gave a brown nuclear reactivity dispersed heterogeneously in a tumor cell population and correlated well with the mitotic activities of tumor cells. The finding suggested that Ki-67 staining provides an easily countable index for the study of proliferating cell populations in cervical cancer.

ISSN:0378-7346    

DOI:10.1159/000292539

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Ki67 immunostaining was performed on 48 cases of squamous cell carcinoma of the cervix and AgNOR silver staining on 29 cases. There was no correlation between the clinical stage of the tumor and the two methods of staining but both methods correlated with histological grade. There was no correlation between the two methods of staining in 17 cases where they were done on adjacent blocks of tumor tissue. High Ki67 score but not high AgNOR count was significantly associated with early recurrence.

ISSN:0378-7346    

DOI:10.1159/000292540

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

From 1985 to 1991, 73 hysterectomies were performed on patients suffering from histologically demonstrated adenomatous hyperplasia, grades 1–3, at the Kiel University Hospital of Gynecology. The operations were done within a month from the diagnosis. Three of the patients were under 40 years of age. An exact correspondence between the grade of adenomatous hyperplasia in the abraded material and the uterus specimen was found in only 44% of the cases. In the patients over 40 with adenomatous hyperplasia of any grade demonstrated in the abraded material, an already well-differentiated endometrial carcinoma was found in 16% of the cases, while such a carcinoma was found in 57% of the cases with grade 3 adenomatous hyperplasia! Even though drug therapy with gestagen may have a beneficial effect, a hysterectomy is nevertheless the treatment of choice for adenomatous hyperplasia of grade 2 and grade 3 in patients over 40 because it is not absolutely certain from a diagnostic point of view that the material is representative of the entire mucosa. In women under 40 years of age it is necessary to plan therapy on an individual basis.

ISSN:0378-7346    

DOI:10.1159/000292541

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Background: Epithelial ovarian carcinoma produces steroid hormones that may be of prognostic importance. The steroids are mainly bound to plasma albumin and sex hormone-binding globulin. Alterations in plasma protein levels influence hormonal effects. As plasma prealbumin may reflect changes in the patient’s clinical status better than do albumin determinations, it is of interest to analyze prealbumin in patients with ovarian cancer. Methods: Fifty-one postmenopausal or oophorectomized women with epithelial cancer of the ovary were studied. Plasma prealbumin was analyzed prior to and during chemotherapy. Tumor volumes were evaluated and blood samples were drawn for prealbumin analysis on four occasions at monthly intervals. Plasma levels were compared with one control group of postmenopausal women, one group of fertile women in the follicular phase of the menstrual cycle, and one control group of postmenopausal women with nongynecologic disseminated malignant disease. Results: Prealbumin conentrations are lower in women with carcinoma of the ovary than in postmenopausal controls and the levels correlate inversely to tumor volume. Prealbumin concentrations are decreased in the large tumor group, advanced tumor stage group and in the control group with nongynecologic disseminated malignant disease. During chemotherapy, plasma prealbumin increases concomitantly with the reduction of tumor volume. Initial plasma prealbumin concentration seems to have prognostic importance. Conclusions: Prealbumin may be a sensitive indicator of disturbances in protein metabolism. It may reflect changes in the patient’s clinical status better than do albumin determinations. Prealbumin concentration seems to have a prognostic importance in women with epithelial ovarian carcinoma. Condensation: Prealbumin is studied in women with epithelial ovarian carcinoma prior to and during chemotherapy, and is found to vary inversely with changes in tumor volume.

ISSN:0378-7346    

DOI:10.1159/000292542

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

The expression of p53 in 7 dysgerminomas of the ovary was investigated immunohistochemically with the monoclonal antibodies DAKO-p53/Do-7 and Dianova-p53/Do-l. All the tumors exhibited overexpression of p53 protein. Immunoreactive tumor cell nuclei amounted to more than 50% in 2 tumors, 10–50% in 2 tumors, and less than 10% in 3 tumors. No relationship was found between tumor stage and the degree of p53 expression. Overexpression of p53 thus appears to be very common in dysgerminoma, as it is in epithelial ovarian cancer.

ISSN:0378-7346    

DOI:10.1159/000292543

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Elevated serum CA125 levels may be caused by any condition which produces peritoneal irritation as well as by the presence of various malignancies. This report of a case with atypical presentation of tubo-ovarian abscess and CA125 level of 1,160 U/ml serves to re-emphasize cautious operative planning in patients desirous of reproductive capability in the face of findings highly consistent with probable malignancy. This is the highest reported serum CA125 level in a reproductive age woman with well-documented reversible benign disease.

ISSN:0378-7346    

DOI:10.1159/000292544

出版商:S. Karger AG    

年代:1994

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000290776

出版商:S. Karger AG    

年代:1913

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000290777

出版商:S. Karger AG    

年代:1913

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000290778

出版商:S. Karger AG    

年代:1913

数据来源: Karger