摘要:

An aromatase inhibitor was identified in human follicular fluid. We sought to examine the effects of this inhibitor on granulosa cells, theca cells, a mixture of granulosa and theca cells, and follicles. Granulosa cells, theca cells, the mixture of granulosa and theca cells, and follicles were incubated with [3H]-thymidine and aromatase inhibitor at 37°C for 40 h in Ham F-10 medium. The radioactivities of acid-insoluble fractions were counted. Aromatase inhibitor markedly inhibited the DNA synthesis of granulosa cells and follicles, but it did not inhibit the mixture of granulosa and theca cells. This suggested that aromatase inhibitor was a factor in the follicle paracrine system and acted mainly on granulosa cells

ISSN:0378-7346    

DOI:10.1159/000292692

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

11 mg natural progesterone (P) was administered to 20 healthy menopausal women by means of a nasal spray or intramuscular injection. Circulating P levels were calculated at various times after administration. The spray formulation yielded a CMax of 3.75 ng/ml at TMax = 60 min, the area under the curve (AUC)0–720 being 1,481.6 ± 343. Intramuscular administration yielded a mean Cm3x of 4.137 ng/ml at TMax = 240 min, the AUC0–720 being 2,491.2 ± 540. P absorption was faster through the nasal than through the intramuscular route, but intramuscular administration led to high serum levels for a much longer period.

ISSN:0378-7346    

DOI:10.1159/000292693

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Several studies have shown that plasma/serum copper and ceruloplasmin concentrations are increased in various carcinomas. We determined serum concentrations of ceruloplasmin and plasma copper concentration to evaluate the clinical usefulness of these tests in patients with cervical carcinomas. There was a significantly higher ceruloplasmin concentration in patients with cervical carcinoma compared to healthy controls. Plasma concentrations of copper were not significantly different in the two groups of subjects. The copper to ceruloplasmin ratio was lower in cancer patients than in control subjects. There was a significant increase in the serum concentrations of ceruloplasmin with increasing FIGO stage of cancer. Copper concentration in advanced tumours (FIGO stage 3) were significantly higher compared to control subjects or FIGO 1 and 2. Copper to ceruloplasmin ratio was lower in FIGO stage 2 and 3 patients compared to stage 1 or control subjects. Ceruloplasmin can also discriminate between large tumours which are inoperable and early cervical carcinomas better than copper or copper to ceruloplasmin ratio.

ISSN:0378-7346    

DOI:10.1159/000292694

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Histological repair of the cervical epithelium after CO2 laser conization was studied using resected uterus specimens. (1) Squamous epithelium (ectocervical side) and reserve cells (endocervical side), were seen immediately after conization; (2) HE staining showed that the S-C junction was formed within 4 weeks. (3) Endocervical epithelial repair of the S–C junction tended to be delayed, and the new S–C junction was deeper in the endocervical canal than before conization; (4) The stroma was repaired within 7 weeks, by prompt collagenization.

ISSN:0378-7346    

DOI:10.1159/000292695

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Umbilical-vein blood from eight fetuses who underwent cordocentesis for rapid karyotyping at 19–22 gestational weeks was tested for immunoreactive endothelin-1,2 by means of radioimmunoassay. Endothelin was detected in the serum of all but one of these fetuses. Levels of endothelin-1,2 ranged from 8.5 to 19.2 fmol/ml (mean 13.4 fmol/ml). We speculate that endothelin in the fetoplacental circulation may play a role in the regulation of fetal hemodynamics in utero.

ISSN:0378-7346    

DOI:10.1159/000292696

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Among internal hernias, those through the foramen of Winslow are most commonly observed. The least frequently occurring is that through the broad ligament of the uterus. The present case presented with bowel strangulating obstruction due to a defect of the left broad ligament which could be diagnosed prior to laparotomy. The patient had no significant past history, and had symptoms of colicky pain, nausea, and vomiting. Emergency laparotomy was performed. Gangrenous ileum was resected, and a defect of the broad ligament was observed bilaterally. Past history in this case supported congenital defect of the broad ligament.

ISSN:0378-7346    

DOI:10.1159/000292697

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Squamous cell carcinomas of the endometrium, either primary or secondary extending from the cervix, are rare. We report a 52-year-old woman with squamous cell carcinoma in situ of the cervix associated with squamous cell carcinoma in situ of the endometrium. The patient had received pelvic cobalt therapy 10 years earlier. She presented to the hospital with discomfort in the lower abdomen. Examination revealed vaginal stenosis and pyometra. After cervical cytology and a biopsy showing squamous cell carcinoma in situ, a wide abdominal hysterectomy with bilateral salpingo-oophorectomy (Wertheim modification) was performed. The unusual presentation of cervical carcinoma with a history of previous radiation treatment suggests the need for performing more cytologic and histologic studies on these patients, because of the risk of developing a secondary malignancy.

ISSN:0378-7346    

DOI:10.1159/000292698

出版商:S. Karger AG    

年代:1993

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000290408

出版商:S. Karger AG    

年代:1912

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000290409

出版商:S. Karger AG    

年代:1912

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000316666

出版商:S. Karger AG    

年代:1912

数据来源: Karger