ISSN:0378-7346    

DOI:10.1159/000291551

出版商:S. Karger AG    

年代:1915

数据来源: Karger

摘要:

Spermatozoa, obtained from 20 healthy individuals, were incubated with crude uterine fluid or with a purified IgG fraction obtained from uterine fluid before adding them to cultures with allogeneic lymphocytes. Untreated spermatozoa induced a proliferative 1.5- to 6-fold increase, while the spermatozoa treated with crude uterine fluid or with purified IgG fraction caused 84–100% suppression of lymphocyte blastogenesis. These results suggest the existence of an endogenous uterine fluid factor, apparently IgG, which causes inhibition of lymphocyte proliferation induced by spermatozoa in the uterine lume

ISSN:0378-7346    

DOI:10.1159/000292055

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

Experimental endometriosis in rats was induced by autotransplanting the uterine endometrium to the peritoneum. In all rats, endometrial implants developed into endometriotic tissues similar to those in humans about 2 weeks after transplantation. Natural killer (NK) activity of spleen cells in the endometriosis model rats was significantly (p < 0.05) lower than that in the shamoperated intact rats. The inhibited NK activity in the endometriosis rats recovered to the level in intact rats with danazol (but not buserelin). The supernatant after 24-hour culture of endometrial tissues from both intact and model rats seemed to have significant inhibitory effects on NK activity. The supernatant from endometrial grafts showed significantly (p < 0.05) higher inhibitory effects than that from the endometrial tissues. The inhibitory effects were significantly (p < 0.05) reduced by treatment with danazol or buserelin to the untreated level. In addition, supernatants of unaffected peritoneal tissues from the endometriosis rats had significantly (p < 0.01) higher inhibitory effects on NK activity than those from the intact rats. Even when uterine serosa or silicone was implanted to the peritoneum, the supernatants of the contralateral peritoneal tissues showed significantly (p < 0.05) higher inhibitory effects than those from the intact rats, while having significantly (p < 0.05) lower inhibitory effects than those from the endometriosis rats. These results suggest that this marked inhibitory effect on NK activity by the peritoneum may be associated with the development and progression of endometriosis.

ISSN:0378-7346    

DOI:10.1159/000292056

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

The effects of hormone replacement therapy (HRT) on lymphocytes and granulocytes have never been determined in detail. Ten healthy menopausal women (age 49–51 years; menopause less than 2 years) were treated for 6 months by administering transdermal estradiol (100 µg/day for 21 consecutive days) and oral medroxyprogesterone acetate (10 mg/day from day 10 to day 21). Days 22–28 were therapy-free. All subjects were examined during the first and the last month of treatment: evaluations were carried out on days 0, 8, 21 and 28. CD4+CD45RO+ cells were found to be significantly reduced on day 8. CD56+ cells and CD8+CD1 1b+ cells were decreased on day 21 and recovered basal level on day 28. Natural killer cell function was transiently increased on day 8 and greatly reduced on day 21. During the first month of therapy, the expression of Leu8 and CD1 1b antigens on granulocyte membranes was significantly affected by HRT. Taken together, the results indicate that HRT selectively affects various immune cell sub

ISSN:0378-7346    

DOI:10.1159/000292057

出版商:S. Karger AG    

年代:1996

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000291552

出版商:S. Karger AG    

年代:1915

数据来源: Karger

摘要:

We investigated the prevalence and the consequence of urinary incontinence in the Turkish population, representing a composition of European and Asian populations. During a 12-month period, the standard urinary incontinence questionnaire was answered by 1,250 women of reproductive age who were admitted to the outpatient clinic with various gynecologic complaints, except for women whose main complaints were urinary incontinence. These patients were randomly selected by stratification according to the following five age-groups: 18–24, 25–29, 30–34, 35–39, and 40–44. The prevalence of incontinence was measured for each group. Urinary incontinence prevalence was 24.5%; in 6.6% the incontinence occurred at least once daily. The lowest prevalence was found in the younger age-groups (18–29 years) and the highest in 40–44 years of age. Two hundred and sixty-one incontinent women (85%) had never sought medical help. The results indicated that urinary incontinence was common among women of reproductive age and only few sought medical help. We suggest that more public education about women’s urinary problems and more attention to this problem by physicians are the mainstay

ISSN:0378-7346    

DOI:10.1159/000292059

出版商:S. Karger AG    

年代:1996

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000291553

出版商:S. Karger AG    

年代:1915

数据来源: Karger

摘要:

A 31-year-old woman developed severe ovarian hyperstimulation syndrome (OHSS) after exogenous gonadotropin stimulation for an in vitro fertilization program. Because of refusal of invasive monitoring, thoracic electrical bioimpedance (TEB) was performed to evaluate cardiac function and volume status. TEB pointed out decreased cardiac output (CO: 4.23 liters/min), cardiac index (CI: 2.63) and stroke volume (SV: 57.5 ml/beat). Serial monitoring of hemody-namic variables was then performed. After the data were obtained, fluid management was performed, and the patient recovered from abnormal homeostasis in 3 days. The hemodynamic variables returned to the normal range (CO: 6.85 liters/min, CI: 4.25, SV: 100.5 ml/beat) within the first 24 h. There were no complications such as life-threatening multiple organ failure. We discuss the usefulness of TEB for the fluid management of severe OHSS, as well as its implications.

ISSN:0378-7346    

DOI:10.1159/000292061

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

A case of mucin-producing adenocarcinoma arising from a mature cystic teratoma of the right ovary is reported in a 67-year-old multiparous Japanese woman. The patient underwent total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and adjuvant chemotherapy containing cisplatin, Adriamycin, and cyclophosphamide with the diagnosis of ovarian cancer, probable stage Ic. Treatment was successful even though the tumor extended through the cyst wall.

ISSN:0378-7346    

DOI:10.1159/000292062

出版商:S. Karger AG    

年代:1996

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000291554

出版商:S. Karger AG    

年代:1915

数据来源: Karger