摘要:

Thermocutaneous, vascular, metabolic and hormonal changes were investigated during 11 hot flashes from 6 postmenopausal women. The first detectable change was an increase in finger blood flow with a concomitant enhancement of skin conductance. The increase in skin conductance was followed rapidly by a sharp rise in finger temperature. The main endocrine-metabolic changes associated with the above phenomena were a sharp increase in plasma free fatty acids (∼65%), norepinephrine (∼ 100%) and LH (∼20%) levels. Plasma glucose and cortisol tended to be increased but did not reach statistical significance; on the other hand, plasma insulin, glucagon, growth hormone, epinephrine and dopamine remained unchanged.

ISSN:0378-7346    

DOI:10.1159/000293612

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000316144

出版商:S. Karger AG    

年代:1908

数据来源: Karger

摘要:

The luteinizing hormone (LH) response to metoclopramide (MCP), a dopamine receptor antagonist, and naloxone (NAL), an opioid receptor antagonist, was evaluated in 7 patients with polycystic ovarian disease (PCOD) before and during treatment with purified human urinary follicle-stimulating hormone (hFSH), and in 6 control women during spontaneously ovulating cycles. Before treatment, in all patients both MCP and NAL administration did not increase plasma LH levels. In the 6 subjects ovulating following hFSH treatment the LH response to MCP and NAL at preovulatory and midluteal phases was restored, as it occurred in control women. Our results suggest that in PCOD the dopamine and opioid activity in the hypothalamus are decreased. The reversal of peripheral ovarian response induced by treatment for the induction of ovulation may restore these impaired neuroendocrine activities.

ISSN:0378-7346    

DOI:10.1159/000293613

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Epidermal growth factor receptor (IEGF-R) levels were analyzed in 72 gynecological tumor specimens. Measurable EGR-R levels were found in a significant percentage of ovarian and uterine tumors. Moreover, all vulvar epidermoid carcinomas and uterine sarcomas analyzed were EGF-R positive. In all tumor types examined, scattered EGF-R levels were observed. Higher EGF-R levels were found in metastatic than in primary ovarian tumors. Moreover, EGF-R were found to be more expressed in less differentiated than in well-moderately differentiated endometrial tumors. Our results suggest a role of EGF or EGF-like substances in regulating the growth of gynecological malignancies, and indicate EGF-R expression as a possible prognostic factor.

ISSN:0378-7346    

DOI:10.1159/000293614

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

A case of a endodermal sinus tumor of the ovary in a patient with 45, XO/46, X, dic(Y) mosaicism is reported because of the rarity of the karyotype and condition. A 15-year-old girl was admitted to Yamagata University Hospital because of constipation for several days. Physical examination showed webbing of the neck, cubitus valgus and short stature. Her abdomen was bulging. Chromosomal analysis showed 45, XO/46, X, dic(Yq) mosaicism in karyotype. α-Fetoprotein and CA-125 in the serum were high. A left ovarian tumor was found by laparotomy; however, the right ovary was a streak gonad and the uterus was hypoplastic. An endodermal sinus tumor was diagnosed by a pathologist. After operation, cisplatin-vinblastin-bleomycin chemotherapy was instituted and the tumor marker went down. This patient is still healthy and under observation at the outpatient clinic.

ISSN:0378-7346    

DOI:10.1159/000293615

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Estrogen receptor content in vaginal tissue was quantified in 12 healthy female volunteers during the menstrual cycle. Epithelial biopsies were obtained at cycle days 10 and 21 and investigated by a monoclonal enzyme immunoassay. Measurable amounts of estrogen receptors were found in all women at both sampling occasions. In women with an ovulatory menstrual cycle, a significant fall inVreceptor content was recorded during the luteal phase. Structural and functional changes in the vaginal epithelium during the menstrual cycle may be important for the diagnosis and susceptibility to certain viral infections.

ISSN:0378-7346    

DOI:10.1159/000293616

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000316145

出版商:S. Karger AG    

年代:1908

数据来源: Karger

摘要:

A case of treatment of an ovarian adenocarcinoma (stage IIIc of the IFGO) is reported. The patient underwent a maximal tumor reduction followed by polychemotherapy. After this treatment, a ‘second-look’ laparotomy shows an incomplete remission. An intensive chemotherapy with total abdomen irradiation and protection of medullary toxicity by an autologous bone marrow infusion is performed, with a satisfactory result, without relapse, 16 months after this treatment (or 25 months after the first laparotomy). Reasons which led the authors to perform an autograft and the conditions under which this treatment may be offered are then presen

ISSN:0378-7346    

DOI:10.1159/000293618

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000316146

出版商:S. Karger AG    

年代:1908

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000286964

出版商:S. Karger AG    

年代:1908

数据来源: Karger