摘要:

The early invasive cancer of the human cervix uteri is marked by a higher proliferation rate in its DNA histograms, which is a sign of perforation of the basal membrane. When this process finishes and an invasive carcinoma is present, the range of the DNA values decreases. The carcinoma has possibly reached a silent phase that will end with the penetration into the lymphatic system.

ISSN:0378-7346    

DOI:10.1159/000299419

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Determinations of plasma euglobulin fibrinolytic activity were made in samples of plasma collected during one normal or hormone-simulated cycle in 15 young, normal women and in 11 women using an oral contraceptive low in estrogen. Distinct, individual levels caused the variations of fibrinolytic activity to be larger within the group than individually, and the activity showed only small changes during the cycle. The hormone group showed a marked increase in fibrinolytic activity with distinct fluctuations related to the phase of the cycle. This increase corresponded to that previously reported to be caused by oral contraceptives containing higher concentrations of estrogen.

ISSN:0378-7346    

DOI:10.1159/000299420

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

All commercially available combined oral contraceptives have 17-C-alkylated estrogens (ethinylestradiol or mestranol) as their estrogen components. In postmenopausal replacement therapy nonalkylated ‘natural’ estrogens have been shown to induce less adverse effects in lipid metabolism than alkylated estrogens. To see if this difference is valid also when the respective kinds of estrogens are used as components in oral contraceptives, the lipid metabolic effects from two preparations with the same progestogen component (norethisterone acetate) but with nonalkylated (17β-estradiol; Netagen) and alkylated (ethinylestradiol) estrogen (Netasyn) have been evaluated. Phospholipids, cholesterol, and triglycerides have been assessed in serum and in ultracentrifugally isolated lipoprotein fractions. The serum lecithin fatty acid composition has been analyzed by gas-liquid chromatrography. Netasyn increased the triglyceride content of serum and all lipoprotein fractions while Netagen did not. Netasyn caused a redistribution in the 1-position fatty acids of serum lecithin with an increase in palmitic and a concomitant decrease in stearic acid, a pattern associated with the 17-C-alkylation of a steroid and probably its capacity to inhibit liver excretory function. In the present study the preparation with the non-alkylated estrogen component had less adverse lipid metabolic effects than the conventional oral contraceptive.

ISSN:0378-7346    

DOI:10.1159/000299421

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Continuous transcutanous measurement of pO2 (tcpO2) has been adapted to fetal and neonatal use, utilizing a noninvasive miniaturized modified Clark pO2 electrode attached to the skin by adhesive. The unprepared ear of the adult female Flemish Giant rabbit was used for attachment of the electrode, and blood for arterial pO2 (apO2) was taken from the auricular artery. The rabbits were gently restrained and unanesthetized. The tcpO2 and pO2 were compared at environmental temperatures of 20–23, 50, and 60 °C, in separate experiments. The data demonstrated that tcpO2 is not the same as pO2. It is most clearly related to local blood flow. tcpO2 only indirectly reflects apO2 when peripheral flow is comparable to central flow. Proper use of tcpCh in the fetus and neonate requires cognizance of blood flow conditions for correct interpretation. tcpO2 is not indicative of apO2 when reduced peripheral circulation is present, in the rabbit ear.

ISSN:0378-7346    

DOI:10.1159/000299422

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Intracervical application of prostaglandin E2 in the late first trimester induces (1) softening of the cervix tissue; (2) increase in sulfated glycosaminoglycans (18 ± 12%, mean ± SEM): (3) no change in hyaluronic acid and water; (4) decrease in pepsin-extractable collagen, and (5) apparent decrease in collagenase. A high activity of collagenase in combination with a replacement of collagen with sulfated glycosaminoglycans may be of importance for the ripening process.

ISSN:0378-7346    

DOI:10.1159/000299423

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299424

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The cardiovascular and metabolic responses during acute fetal hypoxia were studied in 7 pregnant sheep near term. Complete reduction of uterine flow (UBF) for 180 s was performed in 13 experiments by inflating a balloon positioned in the maternal aorta. Fetal heart rate (FHR), systolic and diastolic blood pressure (BP) and fetal arterial oxygen saturation (SO2) were measured continuously. Blood samples were taken at short intervals and analyzed for pH, PO2, PO2 SO2 base excess and lactate. Following the reduction of UBF, FHR began to rise after 4.7 ± 14.4 (SD) s and fell after 31.3 s paralleled by the rise of the BP after 23.2 ± 8.2 (SD) s. The fall of FHR was not related to the SO2 at control, but to the decline of the SO2 by 10–15%. There was no critical limit of SO2 at which the FHR started to fall and the BP began to rise. The rise of the FHR after UBF had been released was significantly correlated to the rise of SO2.Lactate production during hypoxia was related to the slope of the SO2 decline, i.e., to the fetal O2 consumption. The total metabolic response during hypoxia and recovery given by the pH area was correlated to the SO2 at control. No correlation between dip area of FHR and PH area could be established.

ISSN:0378-7346    

DOI:10.1159/000299425

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Neonatal neurological findings and the results of a neurological follow-up examination at 4 years of age were compared in two groups of subjects. The first group contained 39 children with an extremely low obstetrical optimality score, the second one contained 38 children with an extremely high obstetrical optimality score. More children were neurologically deviant in the first group than in the second one, both shortly after birth and at 4 years. The predictive power of the neonatal neurological examination was less in the low-optimality group, probably due to false-negative diagnoses in preterm infants.

ISSN:0378-7346    

DOI:10.1159/000299426

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299427

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000283442

出版商:S. Karger AG    

年代:1902

数据来源: Karger