摘要:

92 preeclamptic women with unfavorable cervical states were treated with intracervical application of prostaglandin E2 (PGE2) in gel for cervical priming and/or labor induction. 55 (60%) were delivered after a single PGE2-gel application. In 27 (29%) the cervical state was improved after 24 h and labor could be induced by oxytocin infusion. Thus, 89% of the women were delivered within 48h after a single PGE2-gel application. In 10 women (11 %) a second PGE2-gel application had to be done before oxytocin infusion. The frequency of cesarean sections was low (5%). No case of uterine hypertonus was seen. No gastrointestinal side effects were observed. All newborn infants had an apgar score at 5 min of more than 7 and were in good condition.

ISSN:0378-7346    

DOI:10.1159/000298973

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

An antiprogesterone (RU-486) was administered to women undergoing voluntary interruption of pregnancy. Five patients received 100 mg 12 h before surgical interruption, 5 others received 100 mg twice, 24 and 12 h before interruption, respectively, and another 5 received no drug at all and served as controls. Placentas and deciduae were examined morphologically with the light microscope and by electron microscopy. No specific lesions were detected in placental tissue. With conventional histology, the deciduae showed various degrees of interstitial edema and necrosis, changes which did not enable a distinction between treated cases and controls, although stromal desintegration tended to be more marked in RU-486-treated patients. At the ultrastructural level, the endothelium of decidual capillaries showed striking hyperplasia of the endoplasmic reticulum. Morphometric evaluation showed a statistically significant difference between RU-486-treated patients (2 × 100 mg) and controls. A possible link between these morphological changes and the induction of prostaglandin synthesis by the antiprogesterone is suggested. However, the full significance of the observed lesions remains uncertain and does not allow definite conclusions concerning the abortefacient effect of RU-486.

ISSN:0378-7346    

DOI:10.1159/000298974

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

The concentration of collagen in the human uterine cervix decreases during pregnancy. This change contributes to the ripening process, which facilitates cervical dilatation during labor. It has been suggested that cervical collagen is partly degraded at term and after delivery. In order to evaluate this hypothesis we investigated the proportion of intact to degraded collagen after solubilization of about 86% of the collagen with pepsin in acetic acid. Total collagen was quantitated as hydroxyproline whereas intact collagen was estimated by SDS-gel electrophoresis. The proportion of intact collagen to total collagen did not change during pregnancy and delivery. Furthermore it was similar to that of intact standard collagen. Thus, even if the concentration of collagen is diminished during pregnancy as a result of increased collagenolytic activity, there is no indication of a qualitative change of the remaining collagen.

ISSN:0378-7346    

DOI:10.1159/000298975

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

The effect of 2 mM dibutyryl cyclic AMP (dbcAMP) and 10 and 100 μg/ml gonadotropin-releasing hormone (GnRH) added prior to filter sterilization and of varying oxygen partial pressure (5, 20, and 95% oxygen) were evaluated using explants from each of 4 placentas on each of 6 days of culture. There were significant differences between placentas on days 1 and 2 of culture (both p < 0.025), and day 4 (p < 0.05), but there were no effects of GnRH or varying oxygen partial pressure on output of human chorionic gonadotropin under the conditions evaluated.

ISSN:0378-7346    

DOI:10.1159/000298976

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

The calcium antagonist, nifedipine, was used to identify patients with primary dysmenorrhea caused by myometrial hyperactivity. Twelve patients with severe primary dysmenorrhea received an oral loading dose of 30 mg nifedipine on the first day of menstruation. Nine patients reported prompt relief of the menstrual cramps (within 15–60 min). In 3 patients no pain relief was obtained. In 2 of these subjects, subsequent laparoscopy revealed obvious signs of endometriosis and previous pelvic inflammatory disease as the cause of these patients pain. Moreover, intrauterine pressure recording with microtransducers displayed normal uterine activity in these patients. It is concluded that, due to its prominent tocolytic effect, nifedipine can be used as a simple pharmacologic test to identify patients suffering from severe primary dysmenorrhea. In addition it indicates a subsequent way to treat the disorder.

ISSN:0378-7346    

DOI:10.1159/000298977

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Estradiol-cyclooctyl acetate (E2CoA) dissolved in arachis oil was given orally at a dose of 0.5 mg/day for 21 days to 11 oophorectomized women. The study was performed in two steps. In the first step the effects of E2CoA, administered after an overnight fast, on plasma estrone, estradiol, FSH, LH, prolactin as well as on serum proteins, fatty acids, oral glucose tolerance test and on the cervical and endometrial morphology were compared to the effects of daily oral intake of 25 μg ethinyl estradiol (EE) in a cross-over study. In the second step the effects of E2CoA in nonfasting conditions on plasma estrone, estradiol, FSH and LH were studied. E2CoA alleviated climacteric estrogen-deficiency symptoms in all women. It showed an estrogenic effect on cervical and endometrial morphology and depressed FSH, though more weakly than EE. No side effects were seen. The unchanged metabolic parameters after 21 days of E2CoA treatment may support the assumption of a weak estrogenic effect, but the relatively slow resorption and relatively low estradiol/estrone ratio found in this study do not confirm the hypothesis that the drug is resorbed by the chylomicrones. Further investigation on the resorption of E2CoA in nonfasting women is, however, needed.

ISSN:0378-7346    

DOI:10.1159/000298978

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

The effects of single-dose progesterone administration on cytosolic and nuclear estradiol receptor levels (RCE2, RNE2) in normal human endometrium were studied in a group of 17 women and the results compared to 18 controls. In both groups, RCE2 and RNE2 levels were highest in the mid-cycle phase and lowest in the secretory phase. Although a wide range of values was found in both groups, the levels of RCE2 in the two groups did not differ significantly. It seems that in human endometrium a single progesterone injection does not significantly change RCE2 and RNE2 levels.

ISSN:0378-7346    

DOI:10.1159/000298979

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Peripheral blood lymphocytes from 172 women with various degrees of cervical dysplasia were assayed for responsiveness to cytomegalovirus-induced early and late antigens using lymphocyte stimulation tests. No evidence was found to suggest that any group of patients was specifically sensitized to either of the antigens tested. Neither was there any difference between the patient groups in respect of mitogen-induced stimulation. The concept that cytomegalovirus might be involved in cervical cell transformation leading to carcinoma has therefore not been strengthened as a result of this study.

ISSN:0378-7346    

DOI:10.1159/000298980

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

The concentration of cytoplasmic estrogen receptors (ER) in cancer of the uterine cervix was measured in 30 cases (28 squamous cell carcinomas and 2 adenocarcinomas). The mean ER concentration in squamous cell carcinoma was 19.3 ± 26.0 fmol/mg cytosol protein; for pre- and postmenopausal women 6.82 ± 9.86 and 28.6 ± 30.1 fmol/mg protein, respectively, were found, the latter being significantly higher. When ‘ER-positive’ was defined as concentrations greater than 10 fmol/mg protein, 12 of the 28 cases (43%) were found to be ER-positive. There were no significant differences between the ER concentrations of clinical stage I and II squamous cell carcinomas (19.2 ± 24.2 and 20.9 ± 27.2 fmol/mg, respectively). ER were detectable in the cervical tissue from all of the control cases of myoma of the uterus. There were, however, no differences in the ER content between the proliferative and secretory phases, but the concentration in premenopausal women was significantly lower than that in postmenopausal women. In comparison with the controls, the mean ER level in both pre- and postmenopausal women with squamous cell carcinoma was significantly lower, due to the fact that ER were not detectable in 57% of these cases. Both cases of cervical adenocarcinoma were ER-positive.

ISSN:0378-7346    

DOI:10.1159/000298981

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Intrauterine fetal supraventricular tachycardia is a rare condition often associated with the syndrome of nonimmune hydrops fetalis. When the fetus is preterm it is vital to treat the arrhythmia with maternally administered drugs and different regimens have been reported in the literature. We report 1 case of this arrhythmia successfully treated in utero with maternally administered digoxin resulting in complete reversal of the hydrops fetalis and the birth of a healthy baby. A review of the relevant literature is brought forth.

ISSN:0378-7346    

DOI:10.1159/000298982

出版商:S. Karger AG    

年代:1985

数据来源: Karger