摘要:

In 429 women with the diagnosis of cancer in situ (CIS), we found, during a follow-up time of 10 years, a relapse frequency of 5.3%; conization was the primary treatment in 414 cases, in 13 cases hysterectomy and radiotherapy in 2 cases. We found that the mean age was significantly higher (p < 0.01) when the primary CIS lesion was localized in the cervix (36.8 ± 10.5) compared to localization only on the portio (31.3 ± 8.7). The risk of relapse was significantly higher (p < 0.05) in patients where the primary cone had the lesion localized in the cervix compared to the patients where the primary cone had the lesion localized only to the portio. We found that the localization of PAD relapses appearing later compared to a high degree (about 65 %) with the localization of the primary CIS lesion. Vaginal relapse was, generally speaking, twice as common when the primary CIS lesion was localized in the cervix compared to when it was localized on the portio alone. Alternative treatment methods to the conization operation are discussed and an increased individualization of CIS treatment is emphasized particularly with consideration to age and the localization of the CIS lesion.

ISSN:0378-7346    

DOI:10.1159/000299517

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

The presence of cytosol estrogen (ER) and progestin (PR) receptors in specimens of normal uterine cervix, endometrium, myometrium, Fallopian tubes and corpora lutei or in samples of neoplastic female reproductive tissues was investigated. The material consisted of PR and ER measurements of tissue samples obtained from fertile and post-menopausal women, receptor assays were performed by a dextran-coated charcoal technique. The radio PR/ER was highest in specimens from the Fallopian tubes (44) and endometrium (4–10), 2–3 in specimens of uterine ecto- or endocervical epithelium and about 4 in the myometrium. No ER or PR were found in the four corpora lutei examined. PR or PR/ER ratio in specimens of myoma tissues did not differ from that found in the myometrium specimens. The highest ER and PR values in the endometrium were measured in specimens taken during the late proliferative or intermediate phase of the menstrual cycle. The PR values in specimens from postmenopausal myometrium were lower in comparison with the samples taken from the myometrium of fertile women in contrast to ER values. In the specimens of carcinoma of the vulva and the uterine cervix ER levels were very low, with no measurable values of PR. In the endometrial carcinoma samples the PR/ER ratio was lower than in the normal endometrium. 4 out of 7 specimens taken from ovarian adenocarcinoma had a measurable amount of ER and in 2 out of 7 cases PR.

ISSN:0378-7346    

DOI:10.1159/000299519

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

The histological and ultrastructural features of 15 endometrial carcinomas were analyzed and recorded without knowledge of the steroid receptor content which was determined in the cytosol of the tumor tissue. Serum levels of estrogens were determined in all patients. The importance of this simultaneous determination of the levels of circulating steroid hormones is emphasized. Some degree of correlation was found between the histological grading of the neoplasms and their steroid receptor content. On the contrary, no evident relation seems to exist between steroid hormone-binding capacity and ultrastructural features of the tumor cells. These different results are presented and discussed.

ISSN:0378-7346    

DOI:10.1159/000299521

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

17β-Estradiol (E2), basal body temperature (BBT) and luteinizing hormone (LH), were measured in normally menstruating women. The preovulatory E2 observations were characterized by variations about a constant level followed by a nearly linear rise to a peak. The BBT observations typically varied about a constant level during the preovulatory phase then about a higher constant level during the postovulatory phase. The change points in E2 and BBT were detected using a Bayesian detection rule and a midcycle ‘fertile period’ was marked off. The midcycle ‘fertile periods’ appear to bracket the ovulation event and the method shows promise as a natural family planning method. Several practical limitations of the method are discussed.

ISSN:0378-7346    

DOI:10.1159/000299523

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

In 47 cycles with hormonal evidence of ovulation, the detection and timing of ovulation by basal body temperature (BBT) and by ultrasonographical observation are compared. The ovulation detection rate by ultrasonographical method proves to be considerably higher than by BBT criteria. The timing of the day of ovulation is evaluated, assuming that the ultrasonographical event of follicle disappearance represents ovulation. BBT criteria nadir, coverline and the eye-balling method show a very poor frequency distribution. The result of the FDHP method is a nearly symmetrical distribution, however, with a considerable range. We conclude that ovulation detection and timing by BBT are not reliable.

ISSN:0378-7346    

DOI:10.1159/000299524

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Luteinizing hormone-human chorionic gonadotropin (LH-hCG), follicle-stimulating hormone (FSH), β-human chorionic gonadotropin (β-hCG), estradiol, cortisol and testosterone levels were determined in cord venous serum and the correlation of birth weights with those hormone levels was investigated in 32 male and 35 female fetuses. There were significant negative correlations between LH-hCG or FSH levels and birth weights in the male fetus. Also there was a significant positive correlation between LH-hCG levels and birth weights in the female fetus. This data suggests that there is a sex difference during the development of the pituitary-gonadal axis.

ISSN:0378-7346    

DOI:10.1159/000299525

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

SP1α and SP1β in pregnancy sera were separated by gel chromatography. When these proteins were subjected to crossed immunoelectrophoresis with an antiserum to non-pregnant human serum in the first dimension gel, SP1α was absorbed but SP1β was unaffected. Similarly incubation with such an antiserum caused the precipitation of SP1α but not SP1β. When SP, antiserum was absorbed with either SP1α or SP1β it resulted in the removal of all antibodies to either SP1α or SP1β.

ISSN:0378-7346    

DOI:10.1159/000299526

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

A simple, inexpensive, plastic ocoluder for stepwise and predictable reduction in uterine blood flow has been applied to the chronically prepared pregnant sheep. Uterine blood flow is measured by an electromagnetic blood flow transducer. This device allows measurable decreases in uterine blood flow for the purpose of studying fetal responses to this maneuver.

ISSN:0378-7346    

DOI:10.1159/000299527

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299528

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0378-7346    

DOI:10.1159/000299529

出版商:S. Karger AG    

年代:1982

数据来源: Karger